Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
JCI Insight
Published

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Authors
James N Sleigh, David Villarroel-Campos, Sunaina Surana, Tahmina Wickenden, Yao Tong, Rebecca L Simkin, Jose Norberto S Vargas, Elena R Rhymes, Andrew P Tosolini, Steven J West, Qian Zhang, Xiang-Lei Yang, Giampietro Schiavo
Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.
PLoS One
Published

What does heritability of Alzheimer's disease represent?

Authors
Emily Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda J Myers, Maryam Shoai, Itziar de Rojas, Niccoló Tesi, Henne Holstege, Wiesje M van der Flier, Yolande A L Pijnenburg, Agustin Ruiz, John Hardy, Sven van der Lee, Valentina Escott-Price
What does heritability of Alzheimer's disease represent?
Sci Adv
Published

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.

Authors
Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.
Science
Published

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.

Authors
Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Front Cell Neurosci
Published

Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.

Authors
Rhian Evans, Lewis M Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I Rees, Denise Fitzgerald, B Paul Morgan, James W Neal, Owain W Howell
Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.
JMIR Aging
Published

Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.

Authors
Michael C B David, Magdalena Kolanko, Martina Del Giovane, Helen Lai, Jessica True, Emily Beal, Lucia M Li, Ramin Nilforooshan, Payam Barnaghi, Paresh A Malhotra, Helen Rostill, David Wingfield, Danielle Wilson, Sarah Daniels, David J Sharp, Gregory Scott
Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.
Brain Pathol
Published

Dendritic spine loss in epileptogenic Type II focal cortical dysplasia: Role of enhanced classical complement pathway activation.

Authors
Laura Rossini, Dalia De Santis, Erica Cecchini, Cinzia Cagnoli, Emanuela Maderna, Daniele Cartelli, Bryan Paul Morgan, Megan Torvell, Roberto Spreafico, Roberta di Giacomo, Laura Tassi, Marco de Curtis, Rita Garbelli
Dendritic spine loss in epileptogenic Type II focal cortical dysplasia: Role of enhanced classical complement pathway activation.
Brain
Published

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease.

Authors
Joshua Stevenson-Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla, Eftychia Bellou, Lauren Luckcuck, Rachel Marshall, Rebecca Sims, Bryan Paul Morgan, John Hardy, Bart de Strooper, Julie Williams, Henrik Zetterberg, Valentina Escott-Price
Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease.