Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Acta Neuropathol Commun
Published

Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B.

Authors
Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris van Dalen, Martijn Verdoes, Elizabeth M C Fisher, Frances K Wiseman
Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B.
JAMA
Published

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.

Authors
John R Sims, Jennifer A Zimmer, Cynthia D Evans, Ming Lu, Paul Ardayfio, JonDavid Sparks, Alette M Wessels, Sergey Shcherbinin, Hong Wang, Emel Serap Monkul Nery, Emily C Collins, Paul Solomon, Stephen Salloway, Liana G Apostolova, Oskar Hansson, Craig Ritchie, Dawn A Brooks, Mark Mintun, Daniel M Skovronsky
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.
JAMA
Published

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.

Authors
John R Sims, Jennifer A Zimmer, Cynthia D Evans, Ming Lu, Paul Ardayfio, JonDavid Sparks, Alette M Wessels, Sergey Shcherbinin, Hong Wang, Emel Serap Monkul Nery, Emily C Collins, Paul Solomon, Stephen Salloway, Liana G Apostolova, Oskar Hansson, Craig Ritchie, Dawn A Brooks, Mark Mintun, Daniel M Skovronsky,
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.
BMJ Open
Published

Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.

Authors
Mark Crook-Rumsey, Sarah J C Daniels, Subati Abulikemu, Helen Lai, Adrien Rapeaux, Charalambos Hadjipanayi, Eyal Soreq, Lucia M Li, James Bashford, Julian Jeyasingh-Jacob, Dragos C Gruia, Damion Lambert, Rimona Weil, Adam Hampshire, David J Sharp, Shlomi Haar
Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.
Oncologist
Published

A Novel HRD Signature Is Predictive of FOLFIRINOX Benefit in Metastatic Pancreatic Cancer.

Authors
Kuei-Ting Chen, Russell Madison, Jay Moore, Dexter Jin, Zoe Fleischmann, Justin Newberg, Alexa Schrock, Neeru Bhardwaj, Katherine T Lofgren, Jie He, Garrett Frampton, Priti Hegde, David Fabrizio, Michael J Pishvaian, Ericka Ebot, Aatur Singhi, Ethan Sokol
A Novel HRD Signature Is Predictive of FOLFIRINOX Benefit in Metastatic Pancreatic Cancer.
BMJ Open
Published

Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.

Authors
Mark Crook-Rumsey, Sarah J C Daniels, Subati Abulikemu, Helen Lai, Adrien Rapeaux, Charalambos Hadjipanayi, Eyal Soreq, Lucia M Li, James Bashford, Julian Jeyasingh-Jacob, Dragos C Gruia, Damion Lambert, Rimona Weil, Adam Hampshire, David J Sharp, Shlomi Haar
Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.
Brain
Published

Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

Authors
Maura Malpetti, Thomas E Cope, Duncan Street, P Simon Jones, Frank H Hezemans, Elijah Mak, Kamen A Tsvetanov, Timothy Rittman, W Richard Bevan-Jones, Karalyn Patterson, Luca Passamonti, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.
Brain
Published

Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

Authors
Maura Malpetti, Thomas E Cope, Duncan Street, P Simon Jones, Frank H Hezemans, Elijah Mak, Kamen A Tsvetanov, Timothy Rittman, W Richard Bevan-Jones, Karalyn Patterson, Luca Passamonti, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, John T O'Brien, James B Rowe
Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.
Lancet Neurol
Published

Progression of cerebral amyloid angiopathy: a pathophysiological framework.

Authors
Emma A Koemans, Jasmeer P Chhatwal, Susanne J van Veluw, Ellis S van Etten, Matthias J P van Osch, Marianne A A van Walderveen, Hamid R Sohrabi, Mariel G Kozberg, Zahra Shirzadi, Gisela M Terwindt, Mark A van Buchem, Eric E Smith, David J Werring, Ralph N Martins, Marieke J H Wermer, Steven M Greenberg
Progression of cerebral amyloid angiopathy: a pathophysiological framework.