Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
NPJ Digit Med
Published

Digital remote monitoring for screening and early detection of urinary tract infections.

Authors
Alexander Capstick, Francesca Palermo, Kimberley Zakka, Nan Fletcher-Lloyd, Chloe Walsh, Tianyu Cui, Samaneh Kouchaki, Raphaella Jackson, Martin Tran, Michael Crone, Kirsten Jensen, Paul Freemont, Ravi Vaidyanathan, Magdalena Kolanko, Jessica True, Sarah Daniels, David Wingfield, Ramin Nilforooshan, Payam Barnaghi
Digital remote monitoring for screening and early detection of urinary tract infections.
Acta Neuropathol
Published

p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.

Authors
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
PLoS Comput Biol
Published

Method to determine whether sleep phenotypes are driven by endogenous circadian rhythms or environmental light by combining longitudinal data and personalised mathematical models.

Authors
Anne C Skeldon, Thalia Rodriguez Garcia, Sean F Cleator, Ciro Della Monica, Kiran K G Ravindran, Victoria L Revell, Derk-Jan Dijk
Method to determine whether sleep phenotypes are driven by endogenous circadian rhythms or environmental light by combining longitudinal data and personalised mathematical models.
PLoS Comput Biol
Published

Method to determine whether sleep phenotypes are driven by endogenous circadian rhythms or environmental light by combining longitudinal data and personalised mathematical models.

Authors
Anne C Skeldon, Thalia Rodriguez Garcia, Sean F Cleator, Ciro Della Monica, Kiran K G Ravindran, Victoria L Revell, Derk-Jan Dijk
Method to determine whether sleep phenotypes are driven by endogenous circadian rhythms or environmental light by combining longitudinal data and personalised mathematical models.
Alzheimers Res Ther
Published

Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.

Authors
Thomas Lancaster, Byron Creese, Valentina Escott-Price, Ian Driver, Georgina Menzies, Zunera Khan, Anne Corbett, Clive Ballard, Julie Williams, Kevin Murphy, Hannah Chandler
Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.
Alzheimers Res Ther
Published

Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.

Authors
Thomas Lancaster, Byron Creese, Valentina Escott-Price, Ian Driver, Georgina Menzies, Zunera Khan, Anne Corbett, Clive Ballard, Julie Williams, Kevin Murphy, Hannah Chandler
Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.
N Engl J Med
Published

Tominersen in Adults with Manifest Huntington's Disease.

Authors
Peter McColgan, Alpa Thobhani, Lauren Boak, Scott A Schobel, Alessia Nicotra, Giuseppe Palermo, Dylan Trundell, Julian Zhou, Valerie Schlegel, Patricia Sanwald Ducray, David J Hawellek, Jonas Dorn, Cedric Simillion, Michael Lindemann, Vicki Wheelock, Alexandra Durr, Karen E Anderson, Jeffrey D Long, Edward J Wild, G Bernhard Landwehrmeyer, Blair R Leavitt, Sarah J Tabrizi, Rachelle Doody
Tominersen in Adults with Manifest Huntington's Disease.
N Engl J Med
Published

Tominersen in Adults with Manifest Huntington's Disease.

Authors
Peter McColgan, Alpa Thobhani, Lauren Boak, Scott A Schobel, Alessia Nicotra, Giuseppe Palermo, Dylan Trundell, Julian Zhou, Valerie Schlegel, Patricia Sanwald Ducray, David J Hawellek, Jonas Dorn, Cedric Simillion, Michael Lindemann, Vicki Wheelock, Alexandra Durr, Karen E Anderson, Jeffrey D Long, Edward J Wild, G Bernhard Landwehrmeyer, Blair R Leavitt, Sarah J Tabrizi, Rachelle Doody,
Tominersen in Adults with Manifest Huntington's Disease.
Nat Neurosci
Published

Age-related dysregulation of homeostatic control in neuronal microcircuits.

Authors
Carola I Radulescu, Nazanin Doostdar, Nawal Zabouri, Leire Melgosa-Ecenarro, Xingjian Wang, Sadra Sadeh, Pavlina Pavlidi, Joe Airey, Maksym Kopanitsa, Claudia Clopath, Samuel J Barnes
Age-related dysregulation of homeostatic control in neuronal microcircuits.
Reproduction
Published

Unilateral lesion of the suprachiasmatic nucleus impairs estradiol feedback, follicular development, estrous cycle and ovulation.

Authors
Carlos-Camilo Silva, Diana Pamela Benítez, Angélica Flores, Georgina Daniela Cortés, Elizabeth Vieyra, Cinthia Rocío Juárez-Tapia, Jessica Romero-Reyes, Roberto Domínguez, Diana P Benitez, Shenyi Jiang, Jack Wood, Rui Wang, Chloe M Hall, Carlijn Peerboom, Natalie Wong, Katie M Stringer, Karina S Vitanova, Victoria C Smith, Dhaval Joshi, Takashi Saito, Takaomi C Saido, John Hardy, Jörg Hanrieder, Bart De Strooper, Dervis A Salih, Takshashila Tripathi, Frances A Edwards, Damian M Cummings, Karina S Vitanova, Katie M Stringer, Diana P Benitez, Jonathan Brenton, Damian M Cummings
Unilateral lesion of the suprachiasmatic nucleus impairs estradiol feedback, follicular development, estrous cycle and ovulation.