Publications

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Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Front Hum Neurosci

Published May 24, 2023

Hyper-parameter tuning and feature extraction for asynchronous action detection from sub-thalamic nucleus local field potentials.

Authors

Thomas Martineau, Shenghong He, Ravi Vaidyanathan, Huiling Tan

Hyper-parameter tuning and feature extraction for asynchronous action detection from sub-thalamic nucleus local field potentials.

Int J Mol Sci

Published May 17, 2023

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Authors

Yoel Hirsch, Wendy K Chung, Sergey Novoselov, Louis H Weimer, Alexander Rossor, Charles A LeDuc, Amanda J McPartland, Ernesto Cabrera, Josef Ekstein, Sholem Scher, Rick F Nelson, Giampietro Schiavo, Lindsay B Henderson, Kevin T A Booth

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Int J Mol Sci

Published May 17, 2023

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Authors

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

J Cereb Blood Flow Metab

Published May 14, 2023

Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and clinical implications.

Authors

Moritz Steinruecke, Rebecca Murphy Lonergan, Bhuvaneish T Selvaraj, Siddharthan Chandran, Blanca Diaz-Castro, Maria Stavrou

Blood-CNS barrier dysfunction in amyotrophic lateral sclerosis: Proposed mechanisms and clinical implications.

JMIR Res Protoc

Published May 11, 2023

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

Authors

Ting Su, Rafael A Calvo, Melanie Jouaiti, Sarah Daniels, Pippa Kirby, Derk-Jan Dijk, Ciro Della Monica, Ravi Vaidyanathan

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

JMIR Res Protoc

Published May 11, 2023

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

Authors

Ting Su, Rafael A Calvo, Melanie Jouaiti, Sarah Daniels, Pippa Kirby, Derk-Jan Dijk, Ciro Della Monica, Ravi Vaidyanathan

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

JCI Insight

Published May 08, 2023

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Authors

James N Sleigh, David Villarroel-Campos, Sunaina Surana, Tahmina Wickenden, Yao Tong, Rebecca L Simkin, Jose Norberto S Vargas, Elena R Rhymes, Andrew P Tosolini, Steven J West, Qian Zhang, Xiang-Lei Yang, Giampietro Schiavo

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

JCI Insight

Published May 08, 2023

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Authors

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

PLoS One

Published May 01, 2023

What does heritability of Alzheimer's disease represent?

Authors

Emily Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda J Myers, Maryam Shoai, Itziar de Rojas, Niccoló Tesi, Henne Holstege, Wiesje M van der Flier, Yolande A L Pijnenburg, Agustin Ruiz, John Hardy, Sven van der Lee, Valentina Escott-Price

What does heritability of Alzheimer's disease represent?

Semin Cell Dev Biol

Published Apr 30, 2023

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.

Authors

Leire Melgosa-Ecenarro, Nazanin Doostdar, Carola I Radulescu, Johanna S Jackson, Samuel J Barnes

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.

PLoS One

Published Apr 28, 2023

What does heritability of Alzheimer's disease represent?

Authors

What does heritability of Alzheimer's disease represent?

Sci Rep

Published Apr 28, 2023

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain.

Authors

William Lim Kee Chang, Tiffany G Chan, Federica Raguseo, Aishwarya Mishra, Dani Chattenton, Rafael T M de Rosales, Nicholas J Long, Sophie V Morse

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain.

PLoS One

Published Apr 28, 2023

Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.

Authors

Marius Bauza, Marino Krstulovic, Julija Krupic

Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.

PLoS One

Published Apr 28, 2023

Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.

Authors

Marius Bauza, Marino Krstulovic, Julija Krupic

Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.

Nat Med

Published Apr 21, 2023

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.

Authors

Marie-Gabrielle Duperron, Maria J Knol, Quentin Le Grand, Tavia E Evans, Aniket Mishra, Ami Tsuchida, Gennady Roshchupkin, Takahiro Konuma, David-Alexandre Trégouët, Jose Rafael Romero, Stefan Frenzel, Michelle Luciano, Edith Hofer, Mathieu Bourgey, Nicole D Dueker, Pilar Delgado, Saima Hilal, Rick M Tankard, Florian Dubost, Jean Shin, Yasaman Saba, Nicola J Armstrong, Constance Bordes, Mark E Bastin, Alexa Beiser, Henry Brodaty, Robin Bülow, Caty Carrera, Christopher Chen, Ching-Yu Cheng, Ian J Deary, Piyush G Gampawar, Jayandra J Himali, Jiyang Jiang, Takahisa Kawaguchi, Shuo Li, Melissa Macalli, Pascale Marquis, Zoe Morris, Susana Muñoz Maniega, Susumu Miyamoto, Masakazu Okawa, Matthew Paradise, Pedram Parva, Tatjana Rundek, Muralidharan Sargurupremraj, Sabrina Schilling, Kazuya Setoh, Omar Soukarieh, Yasuharu Tabara, Alexander Teumer, Anbupalam Thalamuthu, Julian N Trollor, Maria C Valdés Hernández, Meike W Vernooij, Uwe Völker, Katharina Wittfeld, Tien Yin Wong, Margaret J Wright, Junyi Zhang, Wanting Zhao, Yi-Cheng Zhu, Helena Schmidt, Perminder S Sachdev, Wei Wen, Kazumichi Yoshida, Anne Joutel, Claudia L Satizabal, Ralph L Sacco, Guillaume Bourque, Mark Lathrop, Tomas Paus, Israel Fernandez-Cadenas, Qiong Yang, Bernard Mazoyer, Philippe Boutinaud, Yukinori Okada, Hans J Grabe, Karen A Mather, Reinhold Schmidt, Marc Joliot, M Arfan Ikram, Fumihiko Matsuda, Christophe Tzourio, Joanna M Wardlaw, Sudha Seshadri, Hieab H H Adams, Stéphanie Debette

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.

Sci Adv

Published Apr 21, 2023

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.

Authors

Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.

Sci Adv

Published Apr 21, 2023

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.

Authors

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.

Nature

Published Apr 14, 2023

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.

Authors

Joselyn S Soto, Yasaman Jami-Alahmadi, Jakelyn Chacon, Stefanie L Moye, Blanca Diaz-Castro, James A Wohlschlegel, Baljit S Khakh

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.