Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Nature

Published Apr 12, 2023

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.

Authors

Joselyn S Soto, Yasaman Jami-Alahmadi, Jakelyn Chacon, Stefanie L Moye, Blanca Diaz-Castro, James A Wohlschlegel, Baljit S Khakh

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.

bioRxiv

Published Apr 06, 2023

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human.

Authors

Philip Hasel, Melissa L Cooper, Anne E Marchildon, Uriel A Rufen-Blanchette, Rachel D Kim, Thong C Ma, Un Jung Kang, Moses V Chao, Shane A Liddelow

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human.

bioRxiv

Published Apr 06, 2023

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human.

Authors

Philip Hasel, Melissa L Cooper, Anne E Marchildon, Uriel A Rufen-Blanchette, Rachel D Kim, Thong C Ma, Un Jung Kang, Moses V Chao, Shane A Liddelow

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human.

Cell Metab

Published Apr 04, 2023

Molecular and metabolic heterogeneity of astrocytes and microglia.

Authors

Philip Hasel, William H Aisenberg, F Chris Bennett, Shane A Liddelow

Molecular and metabolic heterogeneity of astrocytes and microglia.

Cell Metab

Published Apr 04, 2023

Molecular and metabolic heterogeneity of astrocytes and microglia.

Authors

Philip Hasel, William H Aisenberg, F Chris Bennett, Shane A Liddelow

Molecular and metabolic heterogeneity of astrocytes and microglia.

Prostaglandins Leukot Essent Fatty Acids

Published Apr 04, 2023

The potential effects of polyunsaturated ω-3 fatty acids on spinal cord injury: A systematic review & meta-analysis of preclinical evidence.

Authors

W A C MacIntosh-Smith, A Abdallah, C J Cunningham

The potential effects of polyunsaturated ω-3 fatty acids on spinal cord injury: A systematic review & meta-analysis of preclinical evidence.

Neuroimage

Published Apr 01, 2023

An infant sleep electroencephalographic marker of thalamocortical connectivity predicts behavioral outcome in late infancy.

Authors

Valeria Jaramillo, Sarah F Schoch, Andjela Markovic, Malcolm Kohler, Reto Huber, Caroline Lustenberger, Salome Kurth

An infant sleep electroencephalographic marker of thalamocortical connectivity predicts behavioral outcome in late infancy.

Neuroimage

Published Apr 01, 2023

An infant sleep electroencephalographic marker of thalamocortical connectivity predicts behavioral outcome in late infancy.

Authors

Valeria Jaramillo, Sarah F Schoch, Andjela Markovic, Malcolm Kohler, Reto Huber, Caroline Lustenberger, Salome Kurth

An infant sleep electroencephalographic marker of thalamocortical connectivity predicts behavioral outcome in late infancy.

Science

Published Mar 31, 2023

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.

Authors

Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.

Science

Published Mar 31, 2023

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.

Authors

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.

Front Cell Neurosci

Published Mar 22, 2023

Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.

Authors

Rhian Evans, Lewis M Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I Rees, Denise Fitzgerald, B Paul Morgan, James W Neal, Owain W Howell

Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.

Alzheimers Dement

Published Mar 18, 2023

Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease.

Authors

Philip S J Weston, William Coath, Matthew J Harris, Ian B Malone, John Dickson, Franklin I Aigbirhio, David M Cash, Hui Zhang, Jonathan M Schott

Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease.

Science

Published Mar 17, 2023

A cryptic clue to neurodegeneration?

Authors

Niamh O'Brien, Sarah Mizielinska

A cryptic clue to neurodegeneration?

Mol Psychiatry

Published Mar 14, 2023

Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.

Authors

Karen Crawford, Ganna Leonenko, Emily Baker, Detelina Grozeva, Benoit Lan-Leung, Peter Holmans, Julie Williams, Michael C O'Donovan, Valentina Escott-Price, Dobril K Ivanov

Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.

Elife

Published Mar 10, 2023

Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport.

Authors

Oscar Marcelo Lazo, Giampietro Schiavo

Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport.

Elife

Published Mar 10, 2023

Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport.

Authors

Oscar Marcelo Lazo, Giampietro Schiavo

Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport.

JMIR Aging

Published Mar 09, 2023

Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.

Authors

Michael C B David, Magdalena Kolanko, Martina Del Giovane, Helen Lai, Jessica True, Emily Beal, Lucia M Li, Ramin Nilforooshan, Payam Barnaghi, Paresh A Malhotra, Helen Rostill, David Wingfield, Danielle Wilson, Sarah Daniels, David J Sharp, Gregory Scott

Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.

JMIR Aging

Published Mar 09, 2023

Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.

Authors

Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.