Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
The Journal of infectious diseases
Published

Increased cerebrospinal fluid ACE2 fragments as a read-out of brain infection in COVID-19 encephalopathy patients

Authors
Matthew P Lennol, María-Salud García-Ayllón, Carlos Avilés-Granados, Chiara Trasciatti, Chiara Tolassi, Virginia Quaresima, Davide Arici, Viviana Cristillo, Irene Volonghi, Francesca Caprioli, Valeria De Giuli, Sara Mariotto, Sergio Ferrari, Gianluigi Zanusso, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Alessandro Padovani, Andrea Pilotto, Javier Sáez-Valero
Increased cerebrospinal fluid ACE2 fragments as a read-out of brain infection in COVID-19 encephalopathy patients
Brain : a journal of neurology
Published

Post-mortem validation of in vivo TSPO PET as a microglial biomarker

Authors
Sasvi S Wijesinghe, James B Rowe, Hannah D Mason, Kieren S J Allinson, Reuben Thomas, Davi S Vontobel, Tim D Fryer, Young T Hong, Mehtap Bacioglu, Maria Grazia Spillantini, Jelle van den Ameele, John T O'Brien, Sanne Kaalund, Maura Malpetti, Annelies Quaegebeur
Post-mortem validation of in vivo TSPO PET as a microglial biomarker
Neuropathology and applied neurobiology
Published

Enhancing Lateral Resolution Using Two-Colour Direct Stochastic Optical Reconstruction Microscopy to Unravel Synaptic Tau Pathology in Alzheimer's Disease

Authors
Érika Sánchez-Aced, Borja Moya-Llamas, Joaquim Aumatell Escabias, Soraya Torres, Martí Colom-Cadena, Jordi Pegueroles, Cristian de Quintana-Schmidt, Àlex Bayés, Laura Molina-Porcel, Iban Aldecoa, Olivia Belbin, Juan Fortea, Tara Spires-Jones, Sílvia Pujals, Sònia Sirisi, Alberto Lleó
Enhancing Lateral Resolution Using Two-Colour Direct Stochastic Optical Reconstruction Microscopy to Unravel Synaptic Tau Pathology in Alzheimer's Disease
Alzheimer's research & therapy
Published

Synaptic protein CSF levels relate to memory scores in individuals without dementia

Authors
Kirsten E J Wesenhagen, Diederick M de Leeuw, Jori Tomassen, Johan Gobom, Isabelle Bos, Stephanie J B Vos, Pablo Martinez-Lage, Mikel Tainta, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Rik Vandenberghe, Yvonne Freund-Levi, Frans Verhey, Simon Lovestone, Johannes Streffer, Valerija Dobricic, Kaj Blennow, Philip Scheltens, August B Smit, Lars Bertram, Charlotte E Teunissen, Henrik Zetterberg, Betty M Tijms, Pieter Jelle Visser, Alzheimer’s Disease Neuroimaging Initiative
Synaptic protein CSF levels relate to memory scores in individuals without dementia
The lancet. Psychiatry
Published

Efficacy of clozapine versus second-generation antipsychotics in people with treatment-resistant schizophrenia: a systematic review and individual patient data meta-analysis

Authors
Johannes Schneider-Thoma, Tasnim Hamza, Konstantina Chalkou, Spyridon Siafis, Shimeng Dong, Irene Bighelli, Wulf-Peter Hansen, Elfriede Scheuring, John M Davis, Josef Priller, Pierre Baumann, Robert Conley, Joachim Cordes, Deanna Kelly, Michael Kluge, Sanjiv Kumra, Shôn Lewis, Herbert Y Meltzer, Dieter Naber, Nina Schooler, Jan Volavka, Kristian Wahlbeck, Georgia Salanti, Stefan Leucht
Efficacy of clozapine versus second-generation antipsychotics in people with treatment-resistant schizophrenia: a systematic review and individual patient data meta-analysis
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma p-tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10-year window

Authors
Yara Yakoub, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Christine Déry, Cherie Strikwerda-Brown, Frédéric St-Onge, Valentin Ourry, Michael Schöll, Maiya R Geddes, Simon Ducharme, Maxime Montembeault, Pedro Rosa-Neto, Jean-Paul Soucy, John C S Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuve, PREVENT−AD Research Group
Plasma p-tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10-year window
Brain & spine
Published

Blood biomarkers to identify patients with different intracranial lesion combinations after traumatic brain injury

Authors
Pia Koivikko, Ari J Katila, Riikka Sk Takala, Iftakher Hossain, Teemu M Luoto, Rahul Raj, Mari Koivisto, Olli Tenovuo, Kaj Blennow, Peter Hutchinson, Henna-Riikka Maanpää, Mehrbod Mohammadian, Virginia F Newcombe, Jean-Charles Sanchez, Jussi Tallus, Mark van Gils, Henrik Zetterberg, Jussi P Posti
Blood biomarkers to identify patients with different intracranial lesion combinations after traumatic brain injury
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Amyloid is associated with accelerated atrophy in cognitively unimpaired individuals

Authors
Henry Gilreath Stephenson, Tobey J Betthauser, Rebecca Langhough, Erin Jonaitis, Lianlian Du, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nathaniel A Chin, Ozioma C Okonkwo, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Kaj Blennow, Henrik Zetterberg, Barbara B Bendlin
Amyloid is associated with accelerated atrophy in cognitively unimpaired individuals
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

A head-to-head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic

Authors
Federica Anastasi, Aida Fernández-Lebrero, Nicholas J Ashton, Paula Ortiz-Romero, Javier Torres-Torronteras, Armand González-Escalante, Marta Milà-Alomà, José Contador, Greta García-Escobar, Rosa María Manero-Borràs, Irene Navalpotro-Gómez, Esther Jiménez-Moyano, Aparna Sahajan, Qinyu Hao, Bingqing Zhang, Andreas Jeromin, Nathalie Le Bastard, Alicia Nadal, Tahmine Mousavi, Gwendlyn Kollmorgen, Margherita Carboni, Oriol Grau-Rivera, Henrik Zetterberg, Marta Del Campo, Kaj Blennow, Albert Puig-Pijoan, Marc Suárez-Calvet
A head-to-head comparison of plasma biomarkers to detect Alzheimer's disease in a memory clinic
Nature neuroscience
Published

Neuronal polyunsaturated fatty acids are protective in ALS/FTD

Authors
Ashling Giblin, Alexander J Cammack, Niek Blomberg, Sharifah Anoar, Alla Mikheenko, Mireia Carcolé, Magda L Atilano, Alex Hull, Dunxin Shen, Xiaoya Wei, Rachel Coneys, Lele Zhou, Yassene Mohammed, Damien Olivier-Jimenez, Lian Y Wang, Kerri J Kinghorn, Teresa Niccoli, Alyssa N Coyne, Rik van der Kant, Tammaryn Lashley, Martin Giera, Linda Partridge, Adrian M Isaacs
Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Nature communications
Published

Author Correction: On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies

Authors
Kambiz Nanbakhsh, Ahmad Shah Idil, Callum Lamont, Csaba Dücső, Ömer Can Akgun, Domonkos Horváth, Kinga Tóth, Domokos Meszéna, István Ulbert, Federico Mazza, Timothy G Constandinou, Wouter Serdijn, Anne Vanhoestenberghe, Nick Donaldson, Vasiliki Giagka
Author Correction: On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Evaluation of two plasma-based proteotyping assays against APOE ε4 genotyping in a memory clinic setting: The Gothenburg H70 Clinical Studies

Authors
Anna Dittrich, Kaj Blennow, Kübra Tan, Andrea L Benedet, Ingmar Skoog, Kina Höglund, Nicholas J Ashton, Henrik Zetterberg, Silke Kern
Evaluation of two plasma-based proteotyping assays against APOE ε4 genotyping in a memory clinic setting: The Gothenburg H70 Clinical Studies
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data

Authors
Linda Karlsson, Jacob Vogel, Ida Arvidsson, Kalle Åström, Olof Strandberg, Jakob Seidlitz, Richard A I Bethlehem, Erik Stomrud, Rik Ossenkoppele, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Ruben Smith, Shorena Janelidze, Renaud La Joie, Gil D Rabinovici, Alexa Pichet Binette, Niklas Mattsson-Carlgren, Oskar Hansson
Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data