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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers

Authors
Timo Kaleck, Rafael Campos-Martin, Amanda Cano, Maria Victoria Fernández, Pamela Martino-Adami, Luca Kleineidam, Victor M Andrade Fuentes, Kumar P Tripathi, Kayenat Parveen, Raquel Puerta, Itziar de Rojas, Kishore A Ravichandran, Oliver Peters, Julian Hellmann-Regen, Josef Priller, Maria Gemenetzi, Anja Schneider, Jens Wiltfang, Emrah Düzel, Katharina Buerger, Robert Perneczky, Stefan Teipel, Christoph Laske, Frederic Brosseron, Marta Marquié, Daniel LA van den Hove, Mercè Boada, Michael T Heneka, Michael Wagner, Natalie Marchant, Jean-Charles Lambert, Ruth Frikke-Schmidt, Frank Jessen, Agustín Ruiz, Alfredo Ramirez
Replication of blood DNA methylomic signatures associated with cerebrospinal fluid levels of YKL-40 and NfL biomarkers
Science advances
Published

Galectin-3 induces neurodevelopmental apical-basal polarity and regulates gyrification

Authors
Luana Campos Soares, Ning Huang, Hana Bernhardova, Viviana Macarelli, Marva Chan, Lara Nikel, Sara Bandiera, Dongnan Yan, Dhanu Gupta, Elisa M Cruz, Talia Vasaturo-Kolodner, James M Hillis, Matthew Wood, Mootaz Salman, Zoltán Molnár, Eric O'Neill, Francis G Szele
Galectin-3 induces neurodevelopmental apical-basal polarity and regulates gyrification
Nature communications
Published

Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model

Authors
Jack I Wood, Maciej Dulewicz, Alicja Szadziewska, Sophia Weiner, Junyue Ge, Katie Stringer, Sneha Desai, Lydia Fenson, Diana Piotrowska, Gunnar Brinkmalm, Srinivas Koutarapu, Haady B Hajar, Kaj Blennow, Henrik Zetterberg, Damian M Cummings, Jeffrey N Savas, Frances A Edwards, Jörg Hanrieder
Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Associations between fluid biomarkers and PET imaging ([11C]UCB-J) of synaptic pathology in Alzheimer's disease

Authors
Johanna Nilsson, Adam P Mecca, Nicholas J Ashton, Elaheh Salardini, Ryan S O'Dell, Richard E Carson, Andrea L Benedet, Kaj Blennow, Henrik Zetterberg, Christopher H van Dyck, Ann Brinkmalm
Associations between fluid biomarkers and PET imaging ([11C]UCB-J) of synaptic pathology in Alzheimer's disease
Nature communications
Published

CSF total tau as a proxy of synaptic degeneration

Authors
Carolina Soares, Bruna Bellaver, Pamela C L Ferreira, Guilherme Povala, Cristiano Schaffer Aguzzoli, João Pedro Ferrari-Souza, Hussein Zalzale, Firoza Z Lussier, Francieli Rohden, Sarah Abbas, Guilherme Bauer-Negrini, Douglas Teixeira Leffa, Andréa Lessa Benedet, Rebecca Langhough, Tobey J Betthauser, Bradley T Christian, Rachael E Wilson, Dana L Tudorascu, Pedro Rosa-Neto, Thomas K Karikari, Henrik Zetterberg, Kaj Blennow, Eduardo R Zimmer, Sterling C Johnson, Tharick A Pascoal
CSF total tau as a proxy of synaptic degeneration
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Alzheimer's disease traits in Parkinson's disease without α-synuclein seeding

Authors
Bárbara Fernandes Gomes, Carly M Farris, Yihua Ma, Luis Concha-Marambio, Johanna Nilsson, Karin Forsberg, Russ Lebovitz, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, David Bäckström
Alzheimer's disease traits in Parkinson's disease without α-synuclein seeding
Frontiers in veterinary science
Published

Species diversity and risk factors of gastrointestinal nematodes in smallholder dairy calves in Kenya

Authors
Sylvia Cheptoo, Erhan Yalcindag, Lina González Gordon, Benson Rukwaro, Joseph Samuel Kimatu, Joseph Wasonga, Benedict E Karani, Gideon Ndambuki, Susan Migeni, Jesse Kagai, Linus Eric Kiprotich, Nelson Saya, Deepali Vasoya, Getrude Nangekhe, Justus Onguso, Grace Mungai, Barend Mark Bronsvoort, Elizabeth Anne Jessie Cook
Species diversity and risk factors of gastrointestinal nematodes in smallholder dairy calves in Kenya
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Published

The association of umbilical cord blood neurofilament light with non-reassuring fetal status: A prospective observational study

Authors
David Zalcberg, Kaitlin Kramer, Emma Payne, Thomas Payne, Shreeya Marathe, Neha Mahajan, Ashly Liu, Jessica Barry, Andrew Duckworth, Mitchell Brooks, Bradley de Vries, Fernando Gonzalez-Ortiz, Kaj Blennow, Henrik Zetterberg, Adrienne Gordon, Benjamin Moran, Helen J Manning, Robert D Sanders
The association of umbilical cord blood neurofilament light with non-reassuring fetal status: A prospective observational study
Science advances
Published

Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale

Authors
Mohammad Shafieinouri, Samantha Hong, Paul Suhwan Lee, Spencer M Grant, Marzieh Khani, Anant Dadu, Artur F Schumacher Schuh, Mary B Makarious, Rodrigo Sandon, Emily Simmonds, Hirotaka Iwaki, Gracelyn Hill, Cornelis Blauwendraat, Valentina Escott-Price, Yue A Qi, Alastair J Noyce, Armando Reyes-Palomares, Hampton L Leonard, Malu Tansey, Faraz Faghri, Andrew B Singleton, Mike A Nalls, Kristin S Levine, Sara Bandres-Ciga
Gut-brain nexus: Mapping multimodal links to neurodegeneration at biobank scale
Nature aging
Published

Plasma tau biomarkers for biological staging of Alzheimer's disease

Authors
Laia Montoliu-Gaya, Gemma Salvadó, Joseph Therriault, Johanna Nilsson, Shorena Janelidze, Sophia Weiner, Nicholas J Ashton, Andrea L Benedet, Nesrine Rahmouni, Juan Lantero-Rodriguez, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Gunnar Brinkmalm, Erik Stomrud, Henrik Zetterberg, Johan Gobom, Pedro Rosa-Neto, Kaj Blennow, Oskar Hansson
Plasma tau biomarkers for biological staging of Alzheimer's disease
Alzheimer's research & therapy
Published

The association between plasma and MRI biomarkers in dementia with lewy bodies

Authors
Carmen Peña-Bautista, Katharina Bolsewig, Maria C Gonzalez, Nicholas J Ashton, Dag Aarsland, Henrik Zetterberg, Eric Westman, Olivier Bousiges, Frederic Blanc, Charlotte E Teunissen, Afina W Lemstra, Consuelo Cháfer-Pericás, Miguel Baquero, Daniel Ferreira
The association between plasma and MRI biomarkers in dementia with lewy bodies