Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Clinical chemistry and laboratory medicine
Published

Validation of a plasma GFAP immunoassay and establishment of age-related reference values: bridging analytical performance and routine implementation

Authors
Burak Arslan, Ulf Andreasson, Elzbieta Rembeza, Markus Axelsson, Lenka Novakova, Bjørn-Eivind Kirsebom, Tormod Fladby, Anna Dittrich, Silke Kern, Ingmar Skoog, Kaj Blennow, Henrik Zetterberg, Hlin Kvartsberg
Validation of a plasma GFAP immunoassay and establishment of age-related reference values: bridging analytical performance and routine implementation
Brain stimulation
Published

Brief transcranial focused ultrasound stimulation causes lasting modifications to the synaptic circuitry of the hippocampus

Authors
William W Watts, Benjamin Clennell, James K Jiang, Konoha Izaki-Lee, Abhishek Binodh, Robyn Cuthell, Deniz Tonyali, Jon Crompton, Rosie Taaffe, Alanoud Alqahtani, Anna Andrieu, Igino Rafael Besinga, Kate Heesom, Tom G J Steward, Kwangwook Cho, Bruce W Drinkwater, Elek Molnár, Daniel J Whitcomb
Brief transcranial focused ultrasound stimulation causes lasting modifications to the synaptic circuitry of the hippocampus
Scientific reports
Published

Mapping Alzheimer's disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures

Authors
Bo-Hyun Kim, Daeun Shin, Sung Hoon Kang, Hyemin Jang, Jihwan Yun, YuHyun Park, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Sung Tae Kim, Hee Jin Kim, Duk L Na, Jun Pyo Kim, Sang Won Seo
Mapping Alzheimer's disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures
Stroke
Published

Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals

Authors
J Matthijs Biesbroek, Floor A S de Kort, Devasuda Anblagan, Mark E Bastin, Alexa Beiser, Henry Brodaty, Nishi Chaturvedi, Christopher P L H Chen, Bastian Cheng, Ching-Yu Cheng, Simon R Cox, Charles DeCarli, Christian Enzinger, Evan Fletcher, Richard Frayne, Marius de Groot, Saima Hilal, Felicia Huang, M Arfan Ikram, Jiyang Jiang, Bonnie Y K Lam, Pauline Maillard, Carola Mayer, Cheryl R McCreary, Vincent Mok, Susana Muñoz Maniega, Marvin Petersen, Genady Roshchupkin, Perminder S Sachdev, Reinhold Schmidt, Stephan Seiler, Sudha Seshadri, Carole H Sudre, Götz Thomalla, Maria Valdés Hernández, Narayanaswamy Venketasubramanian, Meike W Vernooij, Elisabeth J Vinke, Joanna M Wardlaw, Wei Wen, Hugo J Kuijf, Geert Jan Biessels
Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals
EBioMedicine
Published

Longitudinal association of shorter leukocyte telomere length with CSF biomarker dynamics across early Alzheimer's disease stages in at-risk individuals

Authors
Blanca Rodríguez-Fernández, Armand González-Escalante, Patricia Genius, Tavia E Evans, Paula Ortiz-Romero, Carolina Minguillón, Gwendlyn Kollmorgen, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, Arcadi Navarro, Marc Suárez-Calvet, Aleix Sala-Vila, Marta Crous-Bou, Natàlia Vilor-Tejedor, ALFA Study
Longitudinal association of shorter leukocyte telomere length with CSF biomarker dynamics across early Alzheimer's disease stages in at-risk individuals
Neurology
Published

Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging

Authors
Thomas M Brown, Sarah-Naomi James, Jennifer M Nicholas, Sarah Keuss, Ashvini Keshavan, Ian B Malone, William Coath, Heidi Murray-Smith, David M Cash, Frederik Barkhof, Marcus Richards, Jonathan M Schott, Carole H Sudre, Josephine Barnes
Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging
Neurology
Published

Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease

Authors
Sohyun Yim, Seongbeom Park, Kyoungyoon Lim, Heekyung Kang, Daeun Shin, Hyunjin Jo, Hyemin Jang, Michael W Weiner, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Sung Hoon Kang, Jihwan Yun, Min Young Chun, Eun-Joo Kim, Hee Jin Kim, Duk L Na, Jun Pyo Kim, Sang Won Seo, Kichang Kwak, K-ROAD study and the Alzheimer's Disease Neuroimaging Initiative
Integrating MRI Volume and Plasma p-Tau217 for Amyloid Risk Stratification in Early-Stage Alzheimer Disease