Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Cell
Published

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.

Authors
Kathryn R Bowles, M Catarina Silva, Kristen Whitney, Taylor Bertucci, Joshua E Berlind, Jesse D Lai, Jacob C Garza, Nathan C Boles, Sidhartha Mahali, Kevin H Strang, Jacob A Marsh, Cynthia Chen, Derian A Pugh, Yiyuan Liu, Ronald E Gordon, Susan K Goderie, Rebecca Chowdhury, Steven Lotz, Keith Lane, John F Crary, Stephen J Haggarty, Celeste M Karch, Justin K Ichida, Alison M Goate, Sally Temple
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Brain Behav Immun
Published

Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice.

Authors
Laura J Westacott, Niels Haan, Claudia Evison, Omar Marei, Jeremy Hall, Timothy R Hughes, Malik Zaben, B Paul Morgan, Trevor Humby, Lawrence S Wilkinson, William P Gray
Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice.
Sci Adv
Published

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

Authors
Nicol Birsa, Agnieszka M Ule, Maria Giovanna Garone, Brian Tsang, Francesca Mattedi, P Andrew Chong, Jack Humphrey, Seth Jarvis, Melis Pisiren, Oscar G Wilkins, Micheal L Nosella, Anny Devoy, Cristian Bodo, Rafaela Fernandez de la Fuente, Elizabeth M C Fisher, Alessandro Rosa, Gabriella Viero, Julie D Forman-Kay, Giampietro Schiavo, Pietro Fratta
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.
Sci Adv
Published

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

Authors
Nicol Birsa, Agnieszka M Ule, Maria Giovanna Garone, Brian Tsang, Francesca Mattedi, P Andrew Chong, Jack Humphrey, Seth Jarvis, Melis Pisiren, Oscar G Wilkins, Micheal L Nosella, Anny Devoy, Cristian Bodo, Rafaela Fernandez de la Fuente, Elizabeth M C Fisher, Alessandro Rosa, Gabriella Viero, Julie D Forman-Kay, Giampietro Schiavo, Pietro Fratta
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.
J Neurol Neurosurg Psychiatry
Published

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Authors
Maura Malpetti, Luca Passamonti, Peter Simon Jones, Duncan Street, Timothy Rittman, Timothy D Fryer, Young T Hong, Patricia Vàsquez Rodriguez, William Richard Bevan-Jones, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe
Neuroinflammation predicts disease progression in progressive supranuclear palsy.
J Neurol Neurosurg Psychiatry
Published

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Authors
Maura Malpetti, Luca Passamonti, Peter Simon Jones, Duncan Street, Timothy Rittman, Timothy D Fryer, Young T Hong, Patricia Vàsquez Rodriguez, William Richard Bevan-Jones, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe
Neuroinflammation predicts disease progression in progressive supranuclear palsy.