Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Nat Neurosci
Published

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.

Authors
Sebastiaan De Schepper, Judy Z Ge, Gerard Crowley, Laís S S Ferreira, Dylan Garceau, Christina E Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.
BMJ Open
Published

Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus.

Authors
Charis Wong, Jenna M Gregory, Jing Liao, Kieren Egan, Hanna M Vesterinen, Aimal Ahmad Khan, Maarij Anwar, Caitlin Beagan, Fraser S Brown, John Cafferkey, Alessandra Cardinali, Jane Yi Chiam, Claire Chiang, Victoria Collins, Joyce Dormido, Elizabeth Elliott, Peter Foley, Yu Cheng Foo, Lily Fulton-Humble, Angus B Gane, Stella A Glasmacher, Áine Heffernan, Kiran Jayaprakash, Nimesh Jayasuriya, Amina Kaddouri, Jamie Kiernan, Gavin Langlands, D Leighton, Jiaming Liu, James Lyon, Arpan R Mehta, Alyssa Meng, Vivienne Nguyen, Na Hyun Park, Suzanne Quigley, Yousuf Rashid, Andrea Salzinger, Bethany Shiell, Ankur Singh, Tim Soane, Alexandra Thompson, Olaf Tomala, Fergal M Waldron, Bhuvaneish T Selvaraj, Jeremy Chataway, Robert Swingler, Peter Connick, Suvankar Pal, Siddharthan Chandran, Malcolm Macleod
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus.
BMJ Open
Published

Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus.

Authors
Charis Wong, Jenna M Gregory, Jing Liao, Kieren Egan, Hanna M Vesterinen, Aimal Ahmad Khan, Maarij Anwar, Caitlin Beagan, Fraser S Brown, John Cafferkey, Alessandra Cardinali, Jane Yi Chiam, Claire Chiang, Victoria Collins, Joyce Dormido, Elizabeth Elliott, Peter Foley, Yu Cheng Foo, Lily Fulton-Humble, Angus B Gane, Stella A Glasmacher, Áine Heffernan, Kiran Jayaprakash, Nimesh Jayasuriya, Amina Kaddouri, Jamie Kiernan, Gavin Langlands, D Leighton, Jiaming Liu, James Lyon, Arpan R Mehta, Alyssa Meng, Vivienne Nguyen, Na Hyun Park, Suzanne Quigley, Yousuf Rashid, Andrea Salzinger, Bethany Shiell, Ankur Singh, Tim Soane, Alexandra Thompson, Olaf Tomala, Fergal M Waldron, Bhuvaneish T Selvaraj, Jeremy Chataway, Robert Swingler, Peter Connick, Suvankar Pal, Siddharthan Chandran, Malcolm Macleod
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus.
Int J Stroke
Published

The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis.

Authors
Bonnie Yin Ka Lam, Yuan Cai, Rufus Akinyemi, Geert Jan Biessels, Hilde van den Brink, Christopher Chen, Chin Wai Cheung, King Ngai Chow, Henry Kwun Hang Chung, Marco Duering, Siu Ting Fu, Deborah Gustafson, Saima Hilal, Vincent Ming Ho Hui, Rajesh Kalaria, SangYun Kim, Maggie Li Man Lam, Frank Erik de Leeuw, Ami Sin Man Li, Hugh Stephen Markus, Anna Marseglia, Huijing Zheng, John O'Brien, Leonardo Pantoni, Perminder Singh Sachdev, Eric E Smith, Joanna Wardlaw, Vincent Chung Tong Mok
The global burden of cerebral small vessel disease in low- and middle-income countries: A systematic review and meta-analysis.
Nature
Published

Microglia regulate central nervous system myelin growth and integrity.

Authors
Niamh B McNamara, David A D Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F J Bogie, Alana Hoffmann, Rebecca K Holloway, Irene Molina-Gonzalez, Katharine E Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W McColl, Marco Prinz, Tara L Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J A Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E Miron
Microglia regulate central nervous system myelin growth and integrity.
Nature
Published

Microglia regulate central nervous system myelin growth and integrity.

Authors
Niamh B McNamara, David A D Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F J Bogie, Alana Hoffmann, Rebecca K Holloway, Irene Molina-Gonzalez, Katharine E Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W McColl, Marco Prinz, Tara L Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J A Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E Miron
Microglia regulate central nervous system myelin growth and integrity.
Ann Neurol
Published

Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

Authors
Maura Malpetti, P Simon Jones, Thomas E Cope, Negin Holland, Michelle Naessens, Matthew A Rouse, Timothy Rittman, George Savulich, David J Whiteside, Duncan Street, Tim D Fryer, Young T Hong, Selena Milicevic Sephton, Franklin I Aigbirhio, John T O Brien, James B Rowe
Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.
Ann Neurol
Published

Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

Authors
Maura Malpetti, P Simon Jones, Thomas E Cope, Negin Holland, Michelle Naessens, Matthew A Rouse, Timothy Rittman, George Savulich, David J Whiteside, Duncan Street, Tim D Fryer, Young T Hong, Selena Milicevic Sephton, Franklin I Aigbirhio, John T O Brien, James B Rowe
Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.
Ann Neurol
Published

CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI.

Authors
Hilde van den Brink, Anna Kopczak, Tine Arts, Laurien Onkenhout, Jeroen C W Siero, Jaco J M Zwanenburg, Sandra Hein, Mathias Hübner, Benno Gesierich, Marco Duering, Michael S Stringer, Jeroen Hendrikse, Joanna M Wardlaw, Anne Joutel, Martin Dichgans, Geert Jan Biessels
CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI.
Nucleic Acids Res
Published

IntroVerse: a comprehensive database of introns across human tissues.

Authors
Sonia García-Ruiz, Emil K Gustavsson, David Zhang, Regina H Reynolds, Zhongbo Chen, Aine Fairbrother-Browne, Ana Luisa Gil-Martínez, Juan A Botia, Leonardo Collado-Torres, Mina Ryten
IntroVerse: a comprehensive database of introns across human tissues.
Nucleic Acids Res
Published

IntroVerse: a comprehensive database of introns across human tissues.

Authors
Sonia García-Ruiz, Emil K Gustavsson, David Zhang, Regina H Reynolds, Zhongbo Chen, Aine Fairbrother-Browne, Ana Luisa Gil-Martínez, Juan A Botia, Leonardo Collado-Torres, Mina Ryten
IntroVerse: a comprehensive database of introns across human tissues.
Brain Commun
Published

Predictive blood biomarkers and brain changes associated with age-related cognitive decline.

Authors
Tyler S Saunders, Francesca E Pozzolo, Amanda Heslegrave, Declan King, Robert I McGeachan, Maxwell P Spires-Jones, Sarah E Harris, Craig Ritchie, Graciela Muniz-Terrera, Ian J Deary, Simon R Cox, Henrik Zetterberg, Tara L Spires-Jones
Predictive blood biomarkers and brain changes associated with age-related cognitive decline.