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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Science
Published

alpha-Synuclein locus triplication causes Parkinson's disease.

Authors
A B Singleton, M Farrer, J Johnson, A Singleton, S Hague, J Kachergus, M Hulihan, T Peuralinna, A Dutra, R Nussbaum, S Lincoln, A Crawley, M Hanson, D Maraganore, C Adler, M R Cookson, M Muenter, M Baptista, D Miller, J Blancato, J Hardy, K Gwinn-Hardy
alpha-Synuclein locus triplication causes Parkinson's disease.
Neuron
Published

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

Authors
Wendy Noble, Vicki Olm, Kazuyuki Takata, Evelyn Casey, O Mary, Jordana Meyerson, Kate Gaynor, John LaFrancois, Lili Wang, Takayuki Kondo, Peter Davies, Mark Burns, Veeranna, Ralph Nixon, Dennis Dickson, Yasuji Matsuoka, Michael Ahlijanian, Lit-Fui Lau, Karen Duff
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
Nature
Published

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.

Authors
M Hutton, C L Lendon, P Rizzu, M Baker, S Froelich, H Houlden, S Pickering-Brown, S Chakraverty, A Isaacs, A Grover, J Hackett, J Adamson, S Lincoln, D Dickson, P Davies, R C Petersen, M Stevens, E de Graaff, E Wauters, J van Baren, M Hillebrand, M Joosse, J M Kwon, P Nowotny, L K Che, J Norton, J C Morris, L A Reed, J Trojanowski, H Basun, L Lannfelt, M Neystat, S Fahn, F Dark, T Tannenberg, P R Dodd, N Hayward, J B Kwok, P R Schofield, A Andreadis, J Snowden, D Craufurd, D Neary, F Owen, B A Oostra, J Hardy, A Goate, J van Swieten, D Mann, T Lynch, P Heutink
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.