Publications

Featured

Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Nat Commun

Published Nov 09, 2016

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.

Authors

Cinzia Cinesi, Lorène Aeschbach, Bin Yang, Vincent Dion

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.

Neurology

Published Nov 08, 2016

Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.

Authors

Philip S J Weston, Jennifer M Nicholas, Manja Lehmann, Natalie S Ryan, Yuying Liang, Kirsty Macpherson, Marc Modat, Martin N Rossor, Jonathan M Schott, Sebastien Ourselin, Nick C Fox

Presymptomatic cortical thinning in familial Alzheimer disease: A longitudinal MRI study.

Genes Dev

Published Oct 01, 2016

Synthetic lethality between PAXX and XLF in mammalian development.

Authors

Gabriel Balmus, Ana C Barros, Paul W G Wijnhoven, Chloé Lescale, Hélène Lenden Hasse, Katharina Boroviak, Carlos le Sage, Brendan Doe, Anneliese O Speak, Antonella Galli, Matt Jacobsen, Ludovic Deriano, David J Adams, Andrew N Blackford, Stephen P Jackson

Synthetic lethality between PAXX and XLF in mammalian development.

Genes Dev

Published Oct 01, 2016

Synthetic lethality between PAXX and XLF in mammalian development.

Authors

Synthetic lethality between PAXX and XLF in mammalian development.

Mol Neurodegener

Published Sep 29, 2016

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease.

Authors

Aitana Sogorb-Esteve, María-Salud García-Ayllón, Juan Fortea, Raquel Sánchez-Valle, Alberto Lleó, José-Luis Molinuevo, Javier Sáez-Valero

Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer's disease.

Nat Neurosci

Published Aug 01, 2016

Neuronal activity enhances tau propagation and tau pathology in vivo.

Authors

Jessica W Wu, S Abid Hussaini, Isle M Bastille, Gustavo A Rodriguez, Ana Mrejeru, Kelly Rilett, David W Sanders, Casey Cook, Hongjun Fu, Rick A C M Boonen, Mathieu Herman, Eden Nahmani, Sheina Emrani, Y Helen Figueroa, Marc I Diamond, Catherine L Clelland, Selina Wray, Karen E Duff

Neuronal activity enhances tau propagation and tau pathology in vivo.

Lancet

Published Jul 30, 2016

Alzheimer's disease.

Authors

Philip Scheltens, Kaj Blennow, Monique M B Breteler, Bart de Strooper, Giovanni B Frisoni, Stephen Salloway, Wiesje Maria Van der Flier

Alzheimer's disease.

Lancet

Published Jul 30, 2016

Alzheimer's disease.

Authors

Philip Scheltens, Kaj Blennow, Monique M B Breteler, Bart de Strooper, Giovanni B Frisoni, Stephen Salloway, Wiesje Maria Van der Flier

Alzheimer's disease.

Nat Neurosci

Published Jul 18, 2016

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

Authors

Alexi Nott, Jemmie Cheng, Fan Gao, Yuan-Ta Lin, Elizabeta Gjoneska, Tak Ko, Paras Minhas, Alicia Viridiana Zamudio, Jia Meng, Feiran Zhang, Peng Jin, Li-Huei Tsai

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

EMBO J

Published Jul 15, 2016

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Authors

Stefan Reber, Jolanda Stettler, Giuseppe Filosa, Martino Colombo, Daniel Jutzi, Silvia C Lenzken, Christoph Schweingruber, Rémy Bruggmann, Angela Bachi, Silvia Ml Barabino, Oliver Mühlemann, Marc-David Ruepp

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

EMBO J

Published Jul 15, 2016

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Authors

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Mol Neurodegener

Published Jun 10, 2016

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Authors

Claire S Harwell, Michael P Coleman

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Science

Published May 06, 2016

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Authors

Soyon Hong, Victoria F Beja-Glasser, Bianca M Nfonoyim, Arnaud Frouin, Shaomin Li, Saranya Ramakrishnan, Katherine M Merry, Qiaoqiao Shi, Arnon Rosenthal, Ben A Barres, Cynthia A Lemere, Dennis J Selkoe, Beth Stevens

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Science

Published May 06, 2016