Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

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- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group

Authors
Ted K S Ng, Chinedu Udeh-Momoh, Mei-Ann Lim, Helena Sophia Gleerup, Wayne Leifert, Catherine Ajalo, Nicholas Ashton, Henrik Zetterberg, Robert A Rissman, Charisse N Winston, Sid O' Bryant, Robert Jenkins, Eva Carro, Gorka Orive, Stefano Tamburin, Marcos Olvera-Rojas, Patricio Solis-Urra, Irene Esteban-Cornejo, Gustavo Alves Andrade Dos Santos, Kumar B Rajan, David Koh, Anja Hviid Simonsen, Paul D Slowey, Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG)
Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Non-APOE variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer's disease genetic risk on white matter hyperintensities

Authors
Hannah Louise Chandler, Joshua Wheeler, Valentina Escott-Price, Kevin Murphy, Thomas Matthew Lancaster
Non-APOE variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer's disease genetic risk on white matter hyperintensities
Neurobiology of aging
Published

Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers

Authors
Elettra Capogna, Øystein Sørensen, Leiv Otto Watne, James Roe, Marie Strømstad, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study of ageing, Anders Martin Fjell, Didac Vidal-Piñeiro
Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers
Molecular neurodegeneration
Published

Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons

Authors
Amir T Marvian, Tabea Strauss, Qilin Tang, Benjamin J Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S Sutherland, William A McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies

Authors
Lucy L Gibson, Maria C Gonzalez, Nicholas J Ashton, Diego Tovar-Rios, Frédéric Blanc, Andrea Pilotto, Afina Lemstra, Claire Paquet, Clive Ballard, Henrik Zetterberg, Dag Aarsland, European–Dementia With Lewy Bodies (E‐DLB) Consortium
Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies
Brain communications
Published

The CSF p-tau/β-amyloid 42 ratio correlates with brain structure and fibrillary β-amyloid deposition in cognitively unimpaired individuals at the earliest stages of pre-clinical Alzheimer's disease

Authors
Raffaele Cacciaglia, Mahnaz Shekari, Gemma Salvadó, Marta Milà-Alomà, Carles Falcon, Gonzalo Sánchez-Benavides, Carolina Minguillón, Karine Fauria, Oriol Grau-Rivera, José Luis Molinuevo, Kaj Blennow, Henrik Zetterberg, Frances-Catherine Quevenco, Marc Suárez-Calvet, Juan Domingo Gispert, ALFA Study
The CSF p-tau/β-amyloid 42 ratio correlates with brain structure and fibrillary β-amyloid deposition in cognitively unimpaired individuals at the earliest stages of pre-clinical Alzheimer's disease
Alzheimer's research & therapy
Published

Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer's disease

Authors
Georgette Argiris, Muge Akinci, Cleofé Peña-Gómez, Eleni Palpatzis, Marina Garcia-Prat, Mahnaz Shekari, Kaj Blennow, Henrik Zetterberg, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nicholas J Ashton, Thomas K Karikari, Ann Brinkmalm-Westman, Juan Lantero-Rodriguez, Karine Fauria, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Marc Suárez-Calvet, Eider M Arenaza-Urquijo, For The Alfa Study
Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer's disease
Nature neuroscience
Published

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

Authors
Naoto Watamura, Martha S Foiani, Sumi Bez, Mathieu Bourdenx, Alessia Santambrogio, Claire Frodsham, Elena Camporesi, Gunnar Brinkmalm, Henrik Zetterberg, Saisha Patel, Naoko Kamano, Mika Takahashi, Javier Rueda-Carrasco, Loukia Katsouri, Stephanie Fowler, Emir Turkes, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Afm Saiful Islam, Seico Benner, Toshihiro Endo, Katsuji Kobayashi, Chiho Ishida, Michele Vendruscolo, Masahito Yamada, Karen E Duff, Takaomi C Saido
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition

Authors
Corey J Bolton, Marilyn Steinbach, Omair A Khan, Dandan Liu, Julia O'Malley, Logan Dumitrescu, Amalia Peterson, Angela L Jefferson, Timothy J Hohman, Henrik Zetterberg, Katherine A Gifford, Alzheimer's Disease Neuroimaging Initiative
Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition
Neurology
Published

Comparison of Plasma p-tau217 and [<sup>18</sup>F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical Dementia

Authors
Kely Monica Quispialaya, Joseph Therriault, Antonio Aliaga, Andrea L Benedet, Nicholas J Ashton, Thomas Karikari, Arthur Cassa Macedo, Nesrine Rahmouni, Cécile Tissot, Jaime Fernandez Arias, Yi-Ting Tina Wang, Lydia Trudel, Seyyed Ali Hosseini, Takashi Matsudaira, Tevy Chan, Tharick Pascoal, Brian Gilfix, Paolo Vitali, Eduardo R Zimmer, Karine Provost, Jean-Paul Soucy, Serge Gauthier, Henrik Zetterberg, Bertrand J Jean-Claude, Kaj Blennow, Pedro Rosa-Neto
Comparison of Plasma p-tau217 and [<sup>18</sup>F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical Dementia
Stem cells (Dayton, Ohio)
Published

Changes in iPSC-Astrocyte morphology reflect Alzheimer's disease patient clinical markers

Authors
Helen A Rowland, Georgina Miller, Qiang Liu, Shuhan Li, Nicola R Sharp, Bryan Ng, Tina Wei, Kanisa Arunasalam, Ivan Koychev, Anne Hedegaard, Elena M Ribe, Dennis Chan, Tharani Chessell, Ece Kocagoncu, Jennifer Lawson, Paresh Malhotra, Basil H Ridha, James B Rowe, Alan J Thomas, Giovanna Zamboni, Henrik Zetterberg, M Zameel Cader, Richard Wade-Martins, Simon Lovestone, Alejo Nevado-Holgado, Andrey Kormilitzin, Noel J Buckley
Changes in iPSC-Astrocyte morphology reflect Alzheimer's disease patient clinical markers