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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Journal of neurochemistry
Published

Alterations of NMDAR Subunits in the Cerebrospinal Fluid Across Neurodegenerative and Immunological Disorders

Authors
Sergio Escamilla, Rocío Pérez-González, Carmen Márquez-Marco, Elena Camporesi, Gunnar Brinkmalm, Alessandro Padovani, Andrea Pilotto, Chiara Tolassi, Davide Arici, Irene Volonghi, Henrik Zetterberg, Kaj Blennow, Jesús Pérez-Pérez, Jaime Kulisevsky, Inmaculada Cuchillo-Ibáñez, Javier Sáez-Valero
Alterations of NMDAR Subunits in the Cerebrospinal Fluid Across Neurodegenerative and Immunological Disorders
The Lancet. Neurology
Published

Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

Authors
Joseph Therriault, Wagner S Brum, Lydia Trudel, Arthur C Macedo, Fernando Valentim Bitencourt, Carolina Castro Martins-Pfeifer, Martin Nakouzi, Ilaria Pola, Matthew Wong, Przemysław R Kac, Ana Paula Real, Chloë Witherow, Thomas K Karikari, Alexis Moscoso, Eduardo R Zimmer, Michael Schöll, Tharick Pascoal, Andrea L Benedet, Nicholas J Ashton, Suzanne E Schindler, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma proteomic analysis identifies proteins and pathways related to Alzheimer's risk

Authors
Yen-Ning Huang, Shiwei Liu, Tamina Park, Soumilee Chaudhuri, Lindsey A Kuchenbecker, Minerva M Carrasquillo, Nilüfer Ertekin-Taner, Paula J Bice, Henrik Zetterberg, Kaj Blennow, Kristen Russ, Jeffrey L Dage, Kelly N H Nudelman, Carlos Cruchaga, Jared R Brosch, Martin R Farlow, David G Clark, Sunu Mathew, Frederick Unverzagt, Sujuan Gao, Sophia Wang, Liana G Apostolova, Donna M Wilcock, Tatiana Foroud, Shannon L Risacher, Andrew J Saykin, Kwangsik Nho
Plasma proteomic analysis identifies proteins and pathways related to Alzheimer's risk
Brain : a journal of neurology
Published

Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease

Authors
Hannah de Bruin, Colin Groot, Henryk Barthel, Gérard N Bischof, Ganna Blazhenets, Ronald Boellaard, Baayla D C Boon, Matthias Brendel, David M Cash, William Coath, Gregory S Day, Bradford C Dickerson, Elena Doering, Alexander Drzezga, Christopher H van Dyck, Thilo van Eimeren, Wiesje M van der Flier, Carolyn A Fredericks, Tim D Fryer, Elsmarieke van de Giessen, Brian A Gordon, Jonathan Graff-Radford, Lea T Grinberg, Oskar Hansson, Diana A Hobbs, Merle C Hoenig, Günter Höglinger, David J Irwin, P Simon Jones, Keith A Josephs, Yuta Katsumi, Renaud La Joie, Edward B Lee, Johannes Levin, Maura Malpetti, Scott M McGinnis, Adam P Mecca, Rosaleena Mohanty, Ilya M Nasrallah, John T O'Brien, Ryan S O'Dell, Carla Palleis, Robert Perneczky, Jeffrey S Phillips, Deepti Putcha, Gil D Rabinovici, Nesrine Rahmouni, Pedro Rosa-Neto, James B Rowe, Michael Rullmann, Osama Sabri, Dorothee Saur, Andreas Schildan, Jonathan M Schott, Matthias L Schroeter, William W Seeley, Stijn Servaes, Irene Sintini, Ruben Smith, Salvatore Spina, Jenna Stevenson, Erik Stomrud, Olof Strandberg, Joseph Therriault, Pontus Tideman, Alexandra Touroutoglou, Anne E Trainer, Denise Visser, Fattin Wekselman, Philip S J Weston, Jennifer L Whitwell, David A Wolk, Keir Yong, Yolande A L Pijnenburg, Nicolai Franzmeier, Rik Ossenkoppele
Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease
Nature
Published

The genomic origin of the unique chaetognath body plan

Authors
Laura Piovani, Daria Gavriouchkina, Elise Parey, Luke A Sarre, Katja T C A Peijnenburg, José María Martín-Durán, Daniel S Rokhsar, Noriyuki Satoh, Alex de Mendoza, Taichiro Goto, Ferdinand Marlétaz
The genomic origin of the unique chaetognath body plan
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma tau biomarkers are distinctly associated with tau tangles and decreased with Lewy body pathology

Authors
Laia Montoliu-Gaya, Elizabeth Valeriano-Lorenzo, Nicholas J Ashton, Francisco J López-González, Juan Lantero-Rodriguez, Alicia Ruiz-González, Ana Belén Pastor, Belen Frades, María Ascensión Zea-Sevilla, Meritxell Valentí, Paloma Ruiz-Valderrey, Laura Saiz, Iván Burgueño-García, Maria José López-Martínez, Teodoro Del Ser, Gunnar Brinkmalm, Henrik Zetterberg, Alberto Rábano, Johan Gobom, Kaj Blennow, Pascual Sánchez-Juan
Plasma tau biomarkers are distinctly associated with tau tangles and decreased with Lewy body pathology
The European journal of neuroscience
Published

Amyloid-Beta Pathology Increases Synaptic Engulfment by Glia in Feline Cognitive Dysfunction Syndrome: A Naturally Occurring Model of Alzheimer's Disease

Authors
Robert I McGeachan, Lucy Ewbank, Meg Watt, Lorena Sordo, Alexandra Malbon, Muhammad Khalid F Salamat, Makis Tzioras, Joao Miguel De Frias, Jane Tulloch, Fiona Houston, Danièlle Gunn-Moore, Tara L Spires-Jones
Amyloid-Beta Pathology Increases Synaptic Engulfment by Glia in Feline Cognitive Dysfunction Syndrome: A Naturally Occurring Model of Alzheimer's Disease
The journal of prevention of Alzheimer's disease
Published

Blood pressure and Alzheimer's disease biomarkers in cognitively unimpaired adults: a multicenter study

Authors
Mariona Osset-Malla, Aitana Martínez-Velasco, Gonzalo Sánchez-Benavides, Mariateresa Buongiorno, Alejandro de la Sierra, Mahnaz Shekari, Carolina Minguillon, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Henrik Zetterberg, Kaj Blennow, David Vállez García, Marc Suárez-Calvet, Juan Domingo Gispert, Oriol Grau-Rivera, ALFA Study
Blood pressure and Alzheimer's disease biomarkers in cognitively unimpaired adults: a multicenter study
Alzheimer's & dementia (New York, N. Y.)
Published

More fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles

Authors
Mackenzie Jarchow, Ira Driscoll, Brianne M Breidenbach, Noah Cook, Catherine L Gallagher, Sterling C Johnson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dane B Cook, Dena B Dubal, Ozioma C Okonkwo
More fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles
medRxiv : the preprint server for health sciences
Published

The PREVENT-AD cohort: accelerating Alzheimer's disease research and treatment in Canada and beyond

Authors
Sylvia Villeneuve, Judes Poirier, John C S Breitner, Jennifer Tremblay-Mercier, Jordana Remz, Jean-Michel Raoult, Yara Yakoub, Jonathan Gallego-Rudolf, Ting Qiu, Alfonso Fajardo Valdez, Bery Mohammediyan, Mohammadali Javanray, Amelie Metz, Safa Sanami, Valentin Ourry, Alfie Wearn, Alexandre Pastor-Bernier, Manon Edde, Julie Gonneaud, Cherie Strikwerda-Brown, Christine L Tardif, Claudine J Gauthier, Maxime Descoteaux, Mahsa Dadar, Étienne Vachon-Presseau, Andree-Ann Baril, Simon Ducharme, Maxime Montembeault, Maiya R Geddes, Jean-Paul Soucy, Natasha Rajah, Robert Laforce, Christian Bocti, Christos Davatzikos, Lune Bellec, Pedro Rosa-Neto, Sylvain Baillet, Alan C Evans, D Louis Collins, M Mallar Chakravarty, Kaj Blennow, Henrik Zetterberg, R Nathan Spreng, Alexa Pichet Binette, PREVENT-AD Research Group
The PREVENT-AD cohort: accelerating Alzheimer's disease research and treatment in Canada and beyond
Alzheimer's research & therapy
Published

Plasma phosphorylated tau 217 and amyloid‑β 42/40 for amyloid risk in subgroups

Authors
Heekyoung Kang, Heejin Yoo, Jungah Lee, Soyeon Yoon, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Theresa A Day, Sung Hoon Kang, Jihwan Yun, Min Young Chun, Eun Hye Lee, Jun Pyo Kim, Hee Jin Kim, Duk L Na, Hyemin Jang, Daeun Shin, Sang Won Seo, K-ROAD study group
Plasma phosphorylated tau 217 and amyloid‑β 42/40 for amyloid risk in subgroups
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Retinal vascular reactivity is associated with white matter hyperintensities and dysfunctional cerebrovascular reactivity in cerebral small vessel disease

Authors
Gordon W Blair, Ian J C MacCormick, Sarah McGrory, Tom MacGillivray, Iona Hamilton, Yulu Shi, Francesca Chappell, Michael J Thrippleton, Michael S Stringer, Fergus Doubal, Joanna M Wardlaw
Retinal vascular reactivity is associated with white matter hyperintensities and dysfunctional cerebrovascular reactivity in cerebral small vessel disease
medRxiv : the preprint server for health sciences
Published

Fecal Short-Chain Fatty Acids Vary by Sex and Amyloid Status

Authors
Jessamine F Kuehn, Qijun Zhang, Margo B Heston, Jea Woo Kang, Sandra J Harding, Nancy J Davenport-Sis, Darby C Peter, Robert L Kerby, Vaibhav Vemuganti, Emma C Schiffmann, Michael M Tallon, Joseph Harpt, Arun Hajra, J L Wheeler, Sushma Shankar, Alissa Mickol, Justus Zemberi, Hana Chow, Eric Zhang, Eleanor Clements, Hanna Noughani, Allison Forst, Grace Everitt, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Bradley T Christian, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Henrik Zetterberg, Kaj Blennow, Tyler K Ulland, Federico E Rey, Barbara B Bendlin
Fecal Short-Chain Fatty Acids Vary by Sex and Amyloid Status