Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
PLoS pathogens
Published

Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection

Authors
Zicheng Hu, Paola Cinque, Ameet Dravid, Lars Hagberg, Aylin Yilmaz, Henrik Zetterberg, Dietmar Fuchs, Johanna Gostner, Kaj Blennow, Serena S Spudich, Laura Kincer, Shuntai Zhou, Sarah Beth Joseph, Ronald Swanstrom, Richard W Price, Magnus Gisslén
Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection
Nature medicine
Published

Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction

Authors
Greta K Wood, Brendan F Sargent, Zain-Ul-Abideen Ahmad, Kukatharmini Tharmaratnam, Cordelia Dunai, Franklyn N Egbe, Naomi H Martin, Bethany Facer, Sophie L Pendered, Henry C Rogers, Christopher Hübel, Daniel J van Wamelen, Richard A I Bethlehem, Valentina Giunchiglia, Peter J Hellyer, William Trender, Gursharan Kalsi, Edward Needham, Ava Easton, Thomas A Jackson, Colm Cunningham, Rachel Upthegrove, Thomas A Pollak, Matthew Hotopf, Tom Solomon, Sarah L Pett, Pamela J Shaw, Nicholas Wood, Neil A Harrison, Karla L Miller, Peter Jezzard, Guy Williams, Eugene P Duff, Steven Williams, Fernando Zelaya, Stephen M Smith, Simon Keller, Matthew Broome, Nathalie Kingston, Masud Husain, Angela Vincent, John Bradley, Patrick Chinnery, David K Menon, John P Aggleton, Timothy R Nicholson, John-Paul Taylor, Anthony S David, Alan Carson, Ed Bullmore, Gerome Breen, Adam Hampshire, COVID-CNS Consortium, Benedict D Michael, Stella-Maria Paddick, E Charles Leek
Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

REAL AD-Validation of a realistic screening approach for early Alzheimer's disease

Authors
Antoine Leuzy, Fiona Heeman, Iris Bosch, Frida Lenér, Maria Dottori, Kajsa Quitz, Alexis Moscoso, Silke Kern, Henrik Zetterberg, Kaj Blennow, Michael Schöll
REAL AD-Validation of a realistic screening approach for early Alzheimer's disease
Imaging neuroscience (Cambridge, Mass.)
Published

The past, present, and future of the brain imaging data structure (BIDS)

Authors
Russell A Poldrack, Christopher J Markiewicz, Stefan Appelhoff, Yoni K Ashar, Tibor Auer, Sylvain Baillet, Shashank Bansal, Leandro Beltrachini, Christian G Benar, Giacomo Bertazzoli, Suyash Bhogawar, Ross W Blair, Marta Bortoletto, Mathieu Boudreau, Teon L Brooks, Vince D Calhoun, Filippo Maria Castelli, Patricia Clement, Alexander L Cohen, Julien Cohen-Adad, Sasha D'Ambrosio, Gilles de Hollander, María de la Iglesia-Vayá, Alejandro de la Vega, Arnaud Delorme, Orrin Devinsky, Dejan Draschkow, Eugene Paul Duff, Elizabeth DuPre, Eric Earl, Oscar Esteban, Franklin W Feingold, Guillaume Flandin, Anthony Galassi, Giuseppe Gallitto, Melanie Ganz, Rémi Gau, James Gholam, Satrajit S Ghosh, Alessio Giacomel, Ashley G Gillman, Padraig Gleeson, Alexandre Gramfort, Samuel Guay, Giacomo Guidali, Yaroslav O Halchenko, Daniel A Handwerker, Nell Hardcastle, Peer Herholz, Dora Hermes, Christopher J Honey, Robert B Innis, Horea-Ioan Ioanas, Andrew Jahn, Agah Karakuzu, David B Keator, Gregory Kiar, Balint Kincses, Angela R Laird, Jonathan C Lau, Alberto Lazari, Jon Haitz Legarreta, Adam Li, Xiangrui Li, Bradley C Love, Hanzhang Lu, Eleonora Marcantoni, Camille Maumet, Giacomo Mazzamuto, Steven L Meisler, Mark Mikkelsen, Henk Mutsaerts, Thomas E Nichols, Aki Nikolaidis, Gustav Nilsonne, Guiomar Niso, Martin Norgaard, Thomas W Okell, Robert Oostenveld, Eduard Ort, Patrick J Park, Mateusz Pawlik, Cyril R Pernet, Franco Pestilli, Jan Petr, Christophe Phillips, Jean-Baptiste Poline, Luca Pollonini, Pradeep Reddy Raamana, Petra Ritter, Gaia Rizzo, Kay A Robbins, Alexander P Rockhill, Christine Rogers, Ariel Rokem, Chris Rorden, Alexandre Routier, Jose Manuel Saborit-Torres, Taylor Salo, Michael Schirner, Robert E Smith, Tamas Spisak, Julia Sprenger, Nicole C Swann, Martin Szinte, Sylvain Takerkart, Bertrand Thirion, Adam G Thomas, Sajjad Torabian, Gael Varoquaux, Bradley Voytek, Julius Welzel, Martin Wilson, Tal Yarkoni, Krzysztof J Gorgolewski
The past, present, and future of the brain imaging data structure (BIDS)
The Lancet. Neurology
Published

Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Authors
Suvankar Pal, Jeremy Chataway, Robert Swingler, Malcolm R Macleod, Neil O Carragher, Giles Hardingham, Bhuvaneish Thangaraj Selvaraj, Colin Smith, Charis Wong, Judith Newton, Dawn Lyle, Amy Stenson, Rachel S Dakin, Amarachi Ihenacho, Shuna Colville, Arpan R Mehta, Nigel Stallard, James R Carpenter, Richard A Parker, Catriona Keerie, Christopher J Weir, Bruce Virgo, Stevie Morris, Nicola Waters, Beverley Gray, Donald MacDonald, Euan MacDonald, Mahesh K B Parmar, Siddharthan Chandran, MND SMART Investigators
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial
EClinicalMedicine
Published

Changes in memory and cognition during the SARS-CoV-2 human challenge study.

Authors
William Trender, Peter J Hellyer, Ben Killingley, Mariya Kalinova, Alex J Mann, Andrew P Catchpole, David Menon, Edward Needham, Ryan Thwaites, Christopher Chiu, Gregory Scott, Adam Hampshire
Changes in memory and cognition during the SARS-CoV-2 human challenge study.
Lancet Neurol
Published

Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial.

Authors
Suvankar Pal, Jeremy Chataway, Robert Swingler, Malcolm R Macleod, Neil O Carragher, Giles Hardingham, Bhuvaneish Thangaraj Selvaraj, Colin Smith, Charis Wong, Judith Newton, Dawn Lyle, Amy Stenson, Rachel S Dakin, Amarachi Ihenacho, Shuna Colville, Arpan R Mehta, Nigel Stallard, James R Carpenter, Richard A Parker, Catriona Keerie, Christopher J Weir, Bruce Virgo, Stevie Morris, Nicola Waters, Beverley Gray, Donald MacDonald, Euan MacDonald, Mahesh K B Parmar, Siddharthan Chandran,
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial.
Acta neuropathologica communications
Published

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids

Authors
Astrid T van der Geest, Channa E Jakobs, Tijana Ljubikj, Christiaan F M Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H Rutten, Marthe Kaal, Maria M Zwartkruis, Mireia Carcolé, Ewout J N Groen, Elly M Hol, Onur Basak, Adrian M Isaacs, Henk-Jan Westeneng, Leonard H van den Berg, Jan H Veldink, Domino K Schlegel, R Jeroen Pasterkamp
Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids
Practical neurology
Published

Genetic testing in dementia

Authors
Antoinette O'Connor, Natalie S Ryan, Christopher R S Belder, David S Lynch, Nayana Lahiri, Henry Houlden, Jonathan D Rohrer, Nick C Fox, Sean O'Dowd
Genetic testing in dementia
Neurology
Published

Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia

Authors
Luigi Lorenzini, Alessio Maranzano, Silvia Ingala, Lyduine E Collij, Mario Tranfa, Kaj Blennow, Carol Di Perri, Christopher Foley, Nick C Fox, Giovanni B Frisoni, Sven Haller, Pablo Martinez-Lage, Daisy Mollison, John O'Brien, Pierre Payoux, Craig Ritchie, Philip Scheltens, Adam J Schwarz, Carole H Sudre, Betty M Tijms, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Pieter Jelle Visser, Adam Waldman, Robin Wolz, Gael Chételat, Michael Ewers, Alle Meije Wink, Henk Mutsaerts, Juan Domingo Gispert, Joanna M Wardlaw, Frederik Barkhof
Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia
Cold Spring Harbor perspectives in biology
Published

Glia in Neurodegenerative Disease

Authors
Gerard Crowley, David Attwell, Hemali Phatnani, Harald Sontheimer, Soyon Hong
Glia in Neurodegenerative Disease
medRxiv : the preprint server for health sciences
Published

Gut Microbiome Compositional and Functional Features Associate with Alzheimer's Disease Pathology

Authors
Jea Woo Kang, Lora A Khatib, Margo B Heston, Amanda H Dilmore, Jennifer S Labus, Yuetiva Deming, Leyla Schimmel, Colette Blach, Daniel McDonald, Antonio Gonzalez, MacKenzie Bryant, Karenina Sanders, Ara Schwartz, Tyler K Ulland, Sterling C Johnson, Sanjay Asthana, Cynthia M Carlsson, Nathaniel A Chin, Kaj Blennow, Henrik Zetterberg, Federico E Rey, Alzheimer Gut Microbiome Project Consortium, Rima Kaddurah-Daouk, Rob Knight, Barbara B Bendlin
Gut Microbiome Compositional and Functional Features Associate with Alzheimer's Disease Pathology