Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
The American journal of pathology
Published

Local Tetanus Begins with a Vesicle-Associated Membrane Protein Cleavage-Associated Neuromuscular Junction Paralysis around the Site of Tetanus Neurotoxin Release

Authors
Federico Fabris, Aram Megighian, Ornella Rossetto, Morena Simonato, Giampietro Schiavo, Marco Pirazzini, Cesare Montecucco
Local Tetanus Begins with a Vesicle-Associated Membrane Protein Cleavage-Associated Neuromuscular Junction Paralysis around the Site of Tetanus Neurotoxin Release
Aging cell
Published

Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

Authors
James N Sleigh, Francesca Mattedi, Sandy Richter, Emily Annuario, Kristal Ng, I Emilie Steinmark, Iveta Ivanova, István L Darabán, Parth P Joshi, Elena R Rhymes, Shirwa Awale, Gokhan Yahioglu, Jacqueline C Mitchell, Klaus Suhling, Giampietro Schiavo, Alessio Vagnoni
Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons
Immunity
Published

The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies

Authors
Barney Viengkhou, Emina Hayashida, Sarah McGlasson, Katie Emelianova, Deborah Forbes, Stewart Wiseman, Joanna Wardlaw, Rovin Verdillo, Sarosh R Irani, Darragh Duffy, Fredrik Piehl, Lipin Loo, Axel Pagenstecher, G Greg Neely, Yanick J Crow, Iain L Campbell, David P J Hunt, Markus J Hofer
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies
Molecular autism
Published

Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder

Authors
Laura Simões de Oliveira, Heather E O'Leary, Sarfaraz Nawaz, Rita Loureiro, Elizabeth C Davenport, Paul Baxter, Susana R Louros, Owen Dando, Emma Perkins, Julien Peltier, Matthias Trost, Emily K Osterweil, Giles E Hardingham, Michael A Cousin, Sumantra Chattarji, Sam A Booker, Tim A Benke, David J A Wyllie, Peter C Kind
Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder
Rheumatology (Oxford, England)
Published

Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus

Authors
Marit Stockfelt, Agnes Torell, Iva Gunnarsson, Elisabet Svenungsson, Agneta Zickert, Maria Majcuk Sennström, Estelle Trysberg, Anders A Bengtsson, Andreas Jönsen, Helena Strevens, Christopher Sjöwall, Muna Saleh, Sofia Pihl, Dag Leonard, Lars Rönnblom, Tansim Akhter, Kaj Blennow, Henrik Zetterberg, Bo Jacobsson, Anna-Carin Lundell, Anna Rudin
Plasma interferon-alpha protein levels during pregnancy are associated with lower birth weight in systemic lupus erythematosus
Frontiers in aging neuroscience
Published

Awareness of episodic memory and meta-cognitive profiles: associations with cerebrospinal fluid biomarkers at the preclinical stage of the Alzheimer's continuum

Authors
David López-Martos, Marc Suárez-Calvet, Marta Milà-Alomà, Juan Domingo Gispert, Carolina Minguillon, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides
Awareness of episodic memory and meta-cognitive profiles: associations with cerebrospinal fluid biomarkers at the preclinical stage of the Alzheimer's continuum
Brain communications
Published

The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia

Authors
Craig W Ritchie, Katie Bridgeman, Sarah Gregory, John T O'Brien, Samuel O Danso, Maria-Eleni Dounavi, Isabelle Carriere, David Driscoll, Robert Hillary, Ivan Koychev, Brian Lawlor, Lorina Naci, Li Su, Audrey Low, Elijah Mak, Paresh Malhotra, Jean Manson, Riccardo Marioni, Lee Murphy, Georgios Ntailianis, William Stewart, Graciela Muniz-Terrera, Karen Ritchie
The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia
Radiology
Published

AmyloidPETNet: Classification of Amyloid Positivity in Brain PET Imaging Using End-to-End Deep Learning

Authors
Shuyang Fan, Maria Rosana Ponisio, Pan Xiao, Sung Min Ha, Satrajit Chakrabarty, John J Lee, Shaney Flores, Pamela LaMontagne, Brian Gordon, Cyrus A Raji, Daniel S Marcus, Arash Nazeri, Beau M Ances, Randall J Bateman, John C Morris, Tammie L S Benzinger, Aristeidis Sotiras, Alzheimer's Disease Neuroimaging Initiative
AmyloidPETNet: Classification of Amyloid Positivity in Brain PET Imaging Using End-to-End Deep Learning
medRxiv : the preprint server for health sciences
Published

A machine learning-based prediction of tau load and distribution in Alzheimer's disease using plasma, MRI and clinical variables

Authors
Linda Karlsson, Jacob Vogel, Ida Arvidsson, Kalle Åström, Olof Strandberg, Jakob Seidlitz, Richard A I Bethlehem, Erik Stomrud, Rik Ossenkoppele, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Ruben Smith, Shorena Janelidze, Renaud La Joie, Gil D Rabinovici, Alexa Pichet Binette, Niklas Mattsson-Carlgren, Oskar Hansson
A machine learning-based prediction of tau load and distribution in Alzheimer's disease using plasma, MRI and clinical variables
Journal of neurology
Published

Genotypes and phenotypes of motor neuron disease: an update of the genetic landscape in Scotland

Authors
Danielle J Leighton, Morad Ansari, Judith Newton, Elaine Cleary, Laura Stephenson, Emily Beswick, Javier Carod Artal, Richard Davenport, Callum Duncan, George H Gorrie, Ian Morrison, Robert Swingler, Ian J Deary, Mary Porteous, Siddharthan Chandran, Suvankar Pal, Lothian Birth Cohorts Group, the CARE-MND Consortium
Genotypes and phenotypes of motor neuron disease: an update of the genetic landscape in Scotland
NPJ Parkinson's disease
Published

Genome-wide determinants of mortality and motor progression in Parkinson's disease

Authors
Manuela M X Tan, Michael A Lawton, Miriam I Pollard, Emmeline Brown, Raquel Real, Alejandro Martinez Carrasco, Samir Bekadar, Edwin Jabbari, Regina H Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Leon Hubbard, Naveed Malek, Katherine A Grosset, Nin Bajaj, Roger A Barker, David J Burn, Catherine Bresner, Thomas Foltynie, Nicholas W Wood, Caroline H Williams-Gray, Ole A Andreassen, Mathias Toft, Alexis Elbaz, Fanny Artaud, Alexis Brice, Jean-Christophe Corvol, Jan Aasly, Matthew J Farrer, Michael A Nalls, Andrew B Singleton, Nigel M Williams, Yoav Ben-Shlomo, John Hardy, Michele T M Hu, Donald G Grosset, Maryam Shoai, Lasse Pihlstrøm, Huw R Morris
Genome-wide determinants of mortality and motor progression in Parkinson's disease
JAMA network open
Published

Biomarkers of Neurobiologic Recovery in Adults With Sport-Related Concussion

Authors
William T O'Brien, Gershon Spitz, Becca Xie, Brendan P Major, Steven Mutimer, Lauren P Giesler, Jesse Bain, Lauren J Evans, Beatriz Duarte Martins, Stefan Piantella, Afizu Alhassan, Shelby Brady, David Cappellari, Vincenzo Somma, Thomas McColl, Georgia F Symons, Tenae Gore, Matthew Sun, Timothy Kuek, Seamus Horan, Michael Bei, Jennie L Ponsford, Catherine Willmott, Jonathan Reyes, Nicholas J Ashton, Henrik Zetterberg, Biswadev Mitra, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald
Biomarkers of Neurobiologic Recovery in Adults With Sport-Related Concussion