Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Cell
Published

Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function

Authors
Lauren V C Miller, Guido Papa, Marina Vaysburd, Shi Cheng, Paul W Sweeney, Annabel Smith, Catarina Franco, Taxiarchis Katsinelos, Melissa Huang, Sophie A I Sanford, Jonathan Benn, Jasmine Farnsworth, Katie Higginson, Holly Joyner, William A McEwan, Leo C James
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function
Translational psychiatry
Published

P-tau217 and other blood biomarkers of dementia: variation with time of day

Authors
Ciro Della Monica, Victoria Revell, Giuseppe Atzori, Rhiannon Laban, Simon S Skene, Amanda Heslegrave, Hana Hassanin, Ramin Nilforooshan, Henrik Zetterberg, Derk-Jan Dijk
P-tau217 and other blood biomarkers of dementia: variation with time of day
The Journal of biological chemistry
Published

Three classes of propofol binding sites on GABA<sub>A</sub> receptors

Authors
Zi-Wei Chen, Satyanarayana M Chintala, John Bracamontes, Yusuke Sugasawa, Spencer R Pierce, Balazs R Varga, Edward H Smith, Christopher J Edge, Nicholas P Franks, Wayland Wl Cheng, Gustav Akk, Alex S Evers
Three classes of propofol binding sites on GABA<sub>A</sub> receptors
Neurology
Published

Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease

Authors
Hye Joo Son, Jae Seung Kim, Randall J Bateman, Seonok Kim, Jorge J Llibre-Guerra, Gregory S Day, Jasmeer P Chhatwal, Sarah B Berman, Peter R Schofield, Mathias Jucker, Johannes Levin, Jae-Hong Lee, Richard J Perrin, John C Morris, Carlos Cruchaga, Jason Hassenstab, Stephen P Salloway, Jai-Hyuen Lee, Alisha Daniels, Dominantly Inherited Alzheimer Network (DIAN)
Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease
The Journal of neuroscience : the official journal of the Society for Neuroscience
Published

<em>Atp13a5</em> Marker Reveals Pericyte Specification in The Mouse Central Nervous System

Authors
Xinying Guo, Shangzhou Xia, Tenghuan Ge, Yangtao Lin, Shirley Hu, Haijian Wu, Xiaochun Xie, Bangyan Zhang, Sonia Zhang, Jianxiong Zeng, Jian-Fu Chen, Axel Montagne, Fan Gao, Qingyi Ma, Zhen Zhao
<em>Atp13a5</em> Marker Reveals Pericyte Specification in The Mouse Central Nervous System
bioRxiv : the preprint server for biology
Published

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease

Authors
Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Tim Bartels, Ulf Dettmer, M Maral Mouradian, Amir Houshang Bahrami, Wei Dai, Jean Baum, Zheng Shi, John Hardy, Eleanna Kara
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
bioRxiv : the preprint server for biology
Published

Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models

Authors
Dimitra Sokolova, Shari Addington Ghansah, Francesca Puletti, Tatiana Georgiades, Sebastiaan De Schepper, Yongjing Zheng, Gerard Crowley, Ling Wu, Javier Rueda-Carrasco, Angeliki Koutsiouroumpa, Philip Muckett, Oliver J Freeman, Baljit S Khakh, Soyon Hong
Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Overview of ADNI MRI

Authors
Clifford R Jack, Arvin Arani, Bret J Borowski, Dave M Cash, Karen Crawford, Sandhitsu R Das, Charles DeCarli, Evan Fletcher, Nick C Fox, Jeffrey L Gunter, Ranjit Ittyerah, Danielle J Harvey, Neda Jahanshad, Pauline Maillard, Ian B Malone, Talia M Nir, Robert I Reid, Denise A Reyes, Christopher G Schwarz, Matthew L Senjem, David L Thomas, Paul M Thompson, Duygu Tosun, Paul A Yushkevich, Chadwick P Ward, Michael W Weiner, Alzheimer's Disease Neuroimaging Initiative
Overview of ADNI MRI
Clinical epigenetics
Published

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

Authors
Danni A Gadd, Hannah M Smith, Donncha Mullin, Ola Chybowska, Robert F Hillary, Dorien M Kimenai, Elena Bernabeu, Yipeng Cheng, Chloe Fawns-Ritchie, Archie Campbell, Danielle Page, Adele Taylor, Janie Corley, Maria Del C Valdés-Hernández, Susana Muñoz Maniega, Mark E Bastin, Joanna M Wardlaw, Rosie M Walker, Kathryn L Evans, Andrew M McIntosh, Caroline Hayward, Tom C Russ, Sarah E Harris, Paul Welsh, Naveed Sattar, Simon R Cox, Daniel L McCartney, Riccardo E Marioni
DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain
Journal of neurology
Published

GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)

Authors
Sabrina Katzdobler, Georg Nübling, Martin Klietz, Urban M Fietzek, Carla Palleis, Alexander M Bernhardt, Florian Wegner, Meret Huber, Sophia Rogozinski, Luisa-Sophie Schneider, Eike Jakob Spruth, Aline Beyle, Ina R Vogt, Moritz Brandt, Niels Hansen, Wenzel Glanz, Kathrin Brockmann, Annika Spottke, Daniel C Hoffmann, Oliver Peters, Josef Priller, Jens Wiltfang, Emrah Düzel, Anja Schneider, Björn Falkenburger, Thomas Klockgether, Thomas Gasser, Brigitte Nuscher, Christian Haass, Günter Höglinger, Johannes Levin
GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)
The Lancet regional health. Europe
Published

Prognostic value of Alzheimer's disease plasma biomarkers in the oldest-old: a prospective primary care-based study

Authors
Pamela V Martino-Adami, Madhurima Chatterjee, Luca Kleineidam, Siegfried Weyerer, Horst Bickel, Birgitt Wiese, Steffi G Riedel-Heller, Martin Scherer, Kaj Blennow, Henrik Zetterberg, Michael Wagner, Anja Schneider, Alfredo Ramirez
Prognostic value of Alzheimer's disease plasma biomarkers in the oldest-old: a prospective primary care-based study
Translational psychiatry
Published

Neuroinflammation, cerebrovascular dysfunction and diurnal cortisol biomarkers in a memory clinic cohort: Findings from the Co-STAR study

Authors
Makrina Daniilidou, Jasper Holleman, Göran Hagman, Ingemar Kåreholt, Malin Aspö, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Alina Solomon, Miia Kivipelto, Shireen Sindi, Anna Matton
Neuroinflammation, cerebrovascular dysfunction and diurnal cortisol biomarkers in a memory clinic cohort: Findings from the Co-STAR study
Journal of neurology
Published

Plasma NfL, GFAP, amyloid, and p-tau species as Prognostic biomarkers in Parkinson's disease

Authors
Andrea Pilotto, Nicholas J Ashton, Alessandro Lupini, Beatrice Battaglio, Cinzia Zatti, Chiara Trasciatti, Stefano Gipponi, Elisabetta Cottini, Ilaria Grossi, Alessandro Salvi, Giuseppina de Petro, Marina Pizzi, Antonio Canale, Kaj Blennow, Henrik Zetterberg, Alessandro Padovani
Plasma NfL, GFAP, amyloid, and p-tau species as Prognostic biomarkers in Parkinson's disease