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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Journal of the neurological sciences
Published

Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders

Authors
Dhamidhu Eratne, Matthew J Y Kang, Courtney Lewis, Christa Dang, Charles Malpas, Suyi Ooi, Amy Brodtmann, David Darby, Henrik Zetterberg, Kaj Blennow, Michael Berk, Olivia Dean, Chad Bousman, Naveen Thomas, Ian Everall, Chris Pantelis, Cassandra Wannan, Claudia Cicognola, Oskar Hansson, Shorena Janelidze, Alexander F Santillo, Dennis Velakoulis, MiND Study Group
Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders
bioRxiv : the preprint server for biology
Published

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates

Authors
Anna E Fürtjes, Isabelle F Foote, Charley Xia, Gail Davies, Joanna Moodie, Adele Taylor, David C Liewald, Paul Redmond, Janie Corley, Andrew M McIntosh, Heather C Whalley, Susana Muñoz Maniega, Maria Valdés Hernández, Ellen Backhouse, Karen Ferguson, Mark E Bastin, Joanna Wardlaw, Javier de la Fuente, Andrew D Grotzinger, Michelle Luciano, W David Hill, Ian J Deary, Elliot M Tucker-Drob, Simon R Cox
Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates
Nature neuroscience
Published

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease

Authors
Stephanie L Fowler, Tiana S Behr, Emir Turkes, Darragh P O'Brien, Paula Maglio Cauhy, Isadora Rawlinson, Marisa Edmonds, Martha S Foiani, Ari Schaler, Gerard Crowley, Sumi Bez, Elena Ficulle, Eliona Tsefou, Roman Fischer, Beth Geary, Pallavi Gaur, Chelsea Miller, Pasquale D'Acunzo, Efrat Levy, Karen E Duff, Benjamin Ryskeldi-Falcon
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease

Authors
Ramiro Eduardo Rea Reyes, Karly A Cody, Rachael E Wilson, Henrik Zetterberg, Nathaniel A Chin, Erin M Jonaitis, Melissa Bahr, Olivia Mandel, Madilynn Wintlend, Barbara B Bendlin, Ozioma C Okonkwo, Lindsay R Clark, Matt Zammit, Sanjay Asthana, Bradley T Christian, Tobey J Betthauser, Laura Eisenmenger, Rebecca E Langhough, Sterling C Johnson
Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases

Authors
William Z Lin, Di Yu, Lisa Y Xiong, Julia Zebarth, Ruoding Wang, Corinne E Fischer, Tarek K Rajji, David F Tang-Wai, Carmela Tartaglia, Gustavo Saposnik, Richard H Swartz, David A Grimes, Anthony E Lang, Robert A Hegele, Sali Farhan, Joel Ramirez, Sean Symons, Maged Goubran, Malcolm A Binns, Wendy Lou, Roger A Dixon, Joseph B Orange, Angela C Roberts, Angela K Troyer, Henrik Zetterberg, Nathan Herrmann, Jennifer S Rabin, Bradley J MacIntosh, Mario Masellis, Krista L Lanctôt, Sandra E Black, Walter Swardfager, ONDRI Investigators
Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases
Annals of neurology
Published

Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease

Authors
Michael S Stringer, Gordon W Blair, Anna Kopczak, Danielle Kerkhofs, Michael J Thrippleton, Francesca M Chappell, Susana Muñoz Maniega, Rosalind Brown, Kirsten Shuler, Iona Hamilton, Daniela Jaime Garcia, Fergus N Doubal, Una Clancy, Eleni Sakka, Tetiana Poliakova, Esther Janssen, Marco Duering, Michael Ingrisch, Julie Staals, Walter H Backes, Robert van Oostenbrugge, Geert Jan Biessels, Martin Dichgans, Joanna M Wardlaw, SVDs@target consortium
Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Associations of life-course cardiovascular risk factors with late-life cerebral haemodynamics

Authors
Mathijs Bj Dijsselhof, Jorina Holtrop, Sarah-Naomi James, Carole H Sudre, Kirsty Lu, Luigi Lorenzini, Lyduine E Collij, Catherine J Scott, Emily N Manning, David L Thomas, Marcus Richards, Alun D Hughes, David M Cash, Frederik Barkhof, Jonathan M Schott, Jan Petr, Henk Jmm Mutsaerts
Associations of life-course cardiovascular risk factors with late-life cerebral haemodynamics
Annals of neurology
Published

Elevated Cerebrospinal Fluid Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers

Authors
Elizabeth R Dellar, Iolanda Vendrell, Benazir Amein, David G Lester, Evan C Edmond, Katie Yoganathan, Thanuja Dharmadasa, Aitana Sogorb-Esteve, Roman Fischer, Kevin Talbot, Jonathan D Rohrer, Martin R Turner, Alexander G Thompson
Elevated Cerebrospinal Fluid Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers
Neurology
Published

Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke: Results From the ENCHANTED Study

Authors
Yanan Wang, Toshiki Maeda, Shoujiang You, Chen Chen, Leibo Liu, Zien Zhou, Thompson G Robinson, Richard Iain Lindley, Candice Delcourt, Grant Mair, Joanna M Wardlaw, John Philip Chalmers, Hisatomi Arima, Yining Huang, Jong S Kim, Pablo M Lavados, Tsong-Hai Lee, Christopher Levi, Mark W Parsons, Sheila Co Martins, Jeyaraj Durai Pandian, Octavio M Pontes-Neto, Vijay K Sharma, Thang Huy Nguyen, Jiguang Wang, Simiao Wu, Ming Liu, Craig S Anderson, Xiaoying Chen, ENCHANTED Investigators
Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke: Results From the ENCHANTED Study
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Published

Dorsal metatarsal artery perforator flaps (DMTAPF) applied for paediatric foot reconstruction: A review of the aetiology of primary injury, surgical technique applied, and long-term outcome for the child

Authors
Yvette Godwin, Mohammed Wadi, Louai Harb, Lise Rosenlund Skov
Dorsal metatarsal artery perforator flaps (DMTAPF) applied for paediatric foot reconstruction: A review of the aetiology of primary injury, surgical technique applied, and long-term outcome for the child
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors

Authors
Eun Hye Lee, Sung Hoon Kang, Daeun Shin, Young Ju Kim, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Bo Kyoung Cheon, Heejin Yoo, Hongki Ham, Jihwan Yun, Jun Pyo Kim, Hee Jin Kim, Duk L Na, Hyemin Jang, Sang Won Seo, K‐ROAD study group
Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors
Alzheimer's research & therapy
Published

Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer's disease

Authors
Qing Qi, Feng Deng, Rebecca Sammon, Karen Ritchie, Graciela Muniz-Terrera, Ivan Koychev, Paresh Malhotra, Siobhan Hutchinson, David Robinson, John T O'Brien, Craig W Ritchie, Brian Lawlor, Lorina Naci
Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer's disease