Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Clinical Manifestations

Authors
Emma-Jane Mallas, Michael Cb David, Hanim Karakoc, Chris Ml Tsoi, Paresh A Malhotra, Gregory Scott, David J Sharp
Clinical Manifestations
medRxiv : the preprint server for health sciences
Published

The CentiMarker Project: Standardizing Quantitative Alzheimer's disease Fluid Biomarkers for Biologic Interpretation

Authors
Guoqiao Wang, Yan Li, Chengjie Xiong, Yuchen Cao, Suzanne E Schindler, Eric McDade, Kaj Blennow, Oskar Hansson, Jeffrey L Dage, Clifford R Jack, Charlotte E Teunissen, Leslie M Shaw, Henrik Zetterberg, Ibanez Laura, Jigyasha Timsina, Cruchaga Carlos, DIAN-TU Study Team, Randall J Bateman
The CentiMarker Project: Standardizing Quantitative Alzheimer's disease Fluid Biomarkers for Biologic Interpretation
Science
Published

Tau suppression in a neurodegenerative mouse model improves memory function

Authors
K. SantaCruz*, J. Lewis*, T. Spires*, J. Paulson, L. Kotilinek, M. Ingelsson, A. Guimaraes, M. DeTure, M. Ramsden, E. McGowan, C. Forster, M. Yue, J. Orne, C. Janus, A. Mariash, M. Kuskowski, B. Hyman, M. Hutton, K. H. Ashe
Tau suppression in a neurodegenerative mouse model improves memory function
Nature
Published

Caspase activation precedes and leads to tangles

Authors
Alix de Calignon, Leora M. Fox, Rose Pitstick, George A. Carlson, Brian J. Bacskai, Tara L. Spires-Jones, Bradley T. Hyman
Caspase activation precedes and leads to tangles
Proceedings of the National Academy of Sciences of the United States of America
Published

Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

Authors
Robert M. Koffie, Melanie Meyer-Luehmann, Tadafumi Hashimoto, Kenneth W. Adams, Matthew L. Mielke, Monica Garcia-Alloza, Kristina D. Micheva, Stephen J. Smith, M. Leo Kim, Virginia M. Lee, Bradley T. Hyman, Tara L. Spires-Jones
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
Nature Protocols
Published

Studying synapses in human brain with array tomography and electron microscopy

Authors
Kevin R Kay, Colin Smith, Ann K Wright, Alberto Serrano-Pozo, Amy M Pooler, Robert Koffie, Mark E Bastin, Thomas H Bak, Sharon Abrahams, Katherine J Kopeikina, Declan McGuone, Matthew P Frosch, Thomas H Gillingwater, Bradley T Hyman, Tara L Spires-Jones
Studying synapses in human brain with array tomography and electron microscopy
Cell Reports Medicine
Published

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

Authors
Makis Tzioras, Michael J.D. Daniels, Caitlin Davies, Paul Baxter, Declan King, Sean McKay, Balazs Varga, Karla Popovic, Madison Hernandez, Anna J. Stevenson, Jack Barrington, Elizabeth Drinkwater, Julia Borella, Rebecca K. Holloway, Jane Tulloch, Jonathan Moss, Clare Latta, Jothy Kandasamy, Drahoslav Sokol, Colin Smith, Veronique E. Miron, Ragnhildur Thóra Káradóttir, Giles E. Hardingham, Christopher M. Henstridge, Paul M. Brennan, Barry W. McColl, Tara L. Spires-Jones
Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8
Cell Reports
Published

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease

Authors
Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d'Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease
Acta Neuropathologica Communications
Published

Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype

Authors
Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Comparative profiling of the synaptic proteome from Alzheimer's disease patients with focus on the APOE genotype
Brain Communications
Published

Predictive blood biomarkers and brain changes associated with age-related cognitive decline

Authors
Tyler S Saunders, Francesca E Pozzolo, Amanda Heslegrave, Declan King, Robert I. McGeachan, Maxwell P Spires-Jones, Sarah E Harris, Craig Ritchie, Graciela Muniz-Terrera, Ian J Deary, Simon R Cox, Henrik Zetterberg, Tara L. Spires-Jones
Predictive blood biomarkers and brain changes associated with age-related cognitive decline
Frontiers in neuroscience
Published

Methodological challenges of measuring brain volumes and cortical thickness in idiopathic normal pressure hydrocephalus with a surface-based approach

Authors
Martina Del Giovane, Michael C B David, Magdalena A Kolanko, Anastasia Gontsarova, Thomas Parker, Adam Hampshire, David J Sharp, Paresh A Malhotra, Christopher Carswell
Methodological challenges of measuring brain volumes and cortical thickness in idiopathic normal pressure hydrocephalus with a surface-based approach