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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Frontiers in aging neuroscience
Published

Awareness of episodic memory and meta-cognitive profiles: associations with cerebrospinal fluid biomarkers at the preclinical stage of the Alzheimer's continuum

Authors
David López-Martos, Marc Suárez-Calvet, Marta Milà-Alomà, Juan Domingo Gispert, Carolina Minguillon, Clara Quijano-Rubio, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides
Awareness of episodic memory and meta-cognitive profiles: associations with cerebrospinal fluid biomarkers at the preclinical stage of the Alzheimer's continuum
Brain communications
Published

The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia

Authors
Craig W Ritchie, Katie Bridgeman, Sarah Gregory, John T O'Brien, Samuel O Danso, Maria-Eleni Dounavi, Isabelle Carriere, David Driscoll, Robert Hillary, Ivan Koychev, Brian Lawlor, Lorina Naci, Li Su, Audrey Low, Elijah Mak, Paresh Malhotra, Jean Manson, Riccardo Marioni, Lee Murphy, Georgios Ntailianis, William Stewart, Graciela Muniz-Terrera, Karen Ritchie
The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia
Radiology
Published

AmyloidPETNet: Classification of Amyloid Positivity in Brain PET Imaging Using End-to-End Deep Learning

Authors
Shuyang Fan, Maria Rosana Ponisio, Pan Xiao, Sung Min Ha, Satrajit Chakrabarty, John J Lee, Shaney Flores, Pamela LaMontagne, Brian Gordon, Cyrus A Raji, Daniel S Marcus, Arash Nazeri, Beau M Ances, Randall J Bateman, John C Morris, Tammie L S Benzinger, Aristeidis Sotiras, Alzheimer's Disease Neuroimaging Initiative
AmyloidPETNet: Classification of Amyloid Positivity in Brain PET Imaging Using End-to-End Deep Learning
medRxiv : the preprint server for health sciences
Published

A machine learning-based prediction of tau load and distribution in Alzheimer's disease using plasma, MRI and clinical variables

Authors
Linda Karlsson, Jacob Vogel, Ida Arvidsson, Kalle Åström, Olof Strandberg, Jakob Seidlitz, Richard A I Bethlehem, Erik Stomrud, Rik Ossenkoppele, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Sebastian Palmqvist, Ruben Smith, Shorena Janelidze, Renaud La Joie, Gil D Rabinovici, Alexa Pichet Binette, Niklas Mattsson-Carlgren, Oskar Hansson
A machine learning-based prediction of tau load and distribution in Alzheimer's disease using plasma, MRI and clinical variables
Journal of neurology
Published

Genotypes and phenotypes of motor neuron disease: an update of the genetic landscape in Scotland

Authors
Danielle J Leighton, Morad Ansari, Judith Newton, Elaine Cleary, Laura Stephenson, Emily Beswick, Javier Carod Artal, Richard Davenport, Callum Duncan, George H Gorrie, Ian Morrison, Robert Swingler, Ian J Deary, Mary Porteous, Siddharthan Chandran, Suvankar Pal, Lothian Birth Cohorts Group, the CARE-MND Consortium
Genotypes and phenotypes of motor neuron disease: an update of the genetic landscape in Scotland
NPJ Parkinson's disease
Published

Genome-wide determinants of mortality and motor progression in Parkinson's disease

Authors
Manuela M X Tan, Michael A Lawton, Miriam I Pollard, Emmeline Brown, Raquel Real, Alejandro Martinez Carrasco, Samir Bekadar, Edwin Jabbari, Regina H Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Leon Hubbard, Naveed Malek, Katherine A Grosset, Nin Bajaj, Roger A Barker, David J Burn, Catherine Bresner, Thomas Foltynie, Nicholas W Wood, Caroline H Williams-Gray, Ole A Andreassen, Mathias Toft, Alexis Elbaz, Fanny Artaud, Alexis Brice, Jean-Christophe Corvol, Jan Aasly, Matthew J Farrer, Michael A Nalls, Andrew B Singleton, Nigel M Williams, Yoav Ben-Shlomo, John Hardy, Michele T M Hu, Donald G Grosset, Maryam Shoai, Lasse Pihlstrøm, Huw R Morris
Genome-wide determinants of mortality and motor progression in Parkinson's disease
JAMA network open
Published

Biomarkers of Neurobiologic Recovery in Adults With Sport-Related Concussion

Authors
William T O'Brien, Gershon Spitz, Becca Xie, Brendan P Major, Steven Mutimer, Lauren P Giesler, Jesse Bain, Lauren J Evans, Beatriz Duarte Martins, Stefan Piantella, Afizu Alhassan, Shelby Brady, David Cappellari, Vincenzo Somma, Thomas McColl, Georgia F Symons, Tenae Gore, Matthew Sun, Timothy Kuek, Seamus Horan, Michael Bei, Jennie L Ponsford, Catherine Willmott, Jonathan Reyes, Nicholas J Ashton, Henrik Zetterberg, Biswadev Mitra, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald
Biomarkers of Neurobiologic Recovery in Adults With Sport-Related Concussion
EMBO molecular medicine
Published

Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients

Authors
Laura de Boni, Amber Wallis, Aurelia Hays Watson, Alejandro Ruiz-Riquelme, Louise-Ann Leyland, Thomas Bourinaris, Naomi Hannaway, Ullrich Wüllner, Oliver Peters, Josef Priller, Björn H Falkenburger, Jens Wiltfang, Mathias Bähr, Inga Zerr, Katharina Bürger, Robert Perneczky, Stefan Teipel, Matthias Löhle, Wiebke Hermann, Björn-Hendrik Schott, Kathrin Brockmann, Annika Spottke, Katrin Haustein, Peter Breuer, Henry Houlden, Rimona S Weil, Tim Bartels
Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients
Neurology
Published

Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies

Authors
Katharina Bolsewig, Annemartijn A J M van Unnik, Elena R Blujdea, Maria C Gonzalez, Nicholas J Ashton, Dag Aarsland, Henrik Zetterberg, Alessandro Padovani, Laura Bonanni, Brit Mollenhauer, Sebastian Schade, Rik Vandenberghe, Koen Poesen, Milica G Kramberger, Claire Paquet, Olivier Bousiges, Benjamin Cretin, Eline A J Willemse, Charlotte E Teunissen, Afina W Lemstra, European-Dementia With Lewy Bodies (E-DLB) Consortium
Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations

Authors
Charles Arber, Christopher R S Belder, Filip Tomczuk, Rebecca Gabriele, Yazead Buhidma, Clíona Farrell, Antoinette O'Connor, Helen Rice, Tammaryn Lashley, Nick C Fox, Natalie S Ryan, Selina Wray
The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations
Nature communications
Published

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease

Authors
Zengjie Xia, Emily E Prescott, Agnieszka Urbanek, Hollie E Wareing, Marianne C King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A Barnes, Martyna M Matuszyk, Eleni Dimou, Eric Hidari, Yu P Zhang, Jeff Y L Lam, John S H Danial, Michael R Strickland, Hong Jiang, Peter Thornton, Damian C Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B Wharton, David M Holtzman, Tarja Malm, Rohan T Ranasinghe, David Klenerman, Suman De
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease
Nat Commun
Published

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.

Authors
Zengjie Xia, Emily E Prescott, Agnieszka Urbanek, Hollie E Wareing, Marianne C King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A Barnes, Martyna M Matuszyk, Eleni Dimou, Eric Hidari, Yu P Zhang, Jeff Y L Lam, John S H Danial, Michael R Strickland, Hong Jiang, Peter Thornton, Damian C Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B Wharton, David M Holtzman, Tarja Malm, Rohan T Ranasinghe, David Klenerman, Suman De
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.
Brain : a journal of neurology
Published

Towards cascading genetic risk in Alzheimer's disease

Authors
Andre Altmann, Leon M Aksman, Neil P Oxtoby, Alexandra Young, ADNI, Daniel C Alexander, Frederik Barkhof, Maryam Shoai, John Hardy, Jonathan M Schott
Towards cascading genetic risk in Alzheimer's disease