Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Eur Stroke J
Published

European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke.

Authors
Joanna M Wardlaw, Hugues Chabriat, Frank-Erik de Leeuw, Stéphanie Debette, Martin Dichgans, Fergus Doubal, Hanna Jokinen, Aristeidis H Katsanos, Raffaele Ornello, Leonardo Pantoni, Marco Pasi, Aleksandra M Pavlovic, Salvatore Rudilosso, Reinhold Schmidt, Julie Staals, Martin Taylor-Rowan, Salman Hussain, Arne G Lindgren
European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke.
NPJ Digit Med
Published

Digital remote monitoring for screening and early detection of urinary tract infections.

Authors
Alexander Capstick, Francesca Palermo, Kimberley Zakka, Nan Fletcher-Lloyd, Chloe Walsh, Tianyu Cui, Samaneh Kouchaki, Raphaella Jackson, Martin Tran, Michael Crone, Kirsten Jensen, Paul Freemont, Ravi Vaidyanathan, Magdalena Kolanko, Jessica True, Sarah Daniels, David Wingfield, , Ramin Nilforooshan, Payam Barnaghi
Digital remote monitoring for screening and early detection of urinary tract infections.
Acta Neuropathol
Published

p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.

Authors
Lewis W Taylor, Elizabeth M Simzer, Claire Pimblett, Oscar T T Lacey-Solymar, Robert I McGeachan, Soraya Meftah, Jamie L Rose, Maxwell P Spires-Jones, Kristján Holt, James H Catterson, Henner Koch, Imran Liaquat, Jonathan H Clarke, John Skidmore, Colin Smith, Sam A Booker, Paul M Brennan, Tara L Spires-Jones, Claire S Durrant
p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.
PLoS Comput Biol
Published

Method to determine whether sleep phenotypes are driven by endogenous circadian rhythms or environmental light by combining longitudinal data and personalised mathematical models.

Authors
Anne C Skeldon, Thalia Rodriguez Garcia, Sean F Cleator, Ciro Della Monica, Kiran K G Ravindran, Victoria L Revell, Derk-Jan Dijk
Method to determine whether sleep phenotypes are driven by endogenous circadian rhythms or environmental light by combining longitudinal data and personalised mathematical models.
Alzheimers Res Ther
Published

Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.

Authors
Thomas Lancaster, Byron Creese, Valentina Escott-Price, Ian Driver, Georgina Menzies, Zunera Khan, Anne Corbett, Clive Ballard, Julie Williams, Kevin Murphy, Hannah Chandler
Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates.
N Engl J Med
Published

Tominersen in Adults with Manifest Huntington's Disease.

Authors
Peter McColgan, Alpa Thobhani, Lauren Boak, Scott A Schobel, Alessia Nicotra, Giuseppe Palermo, Dylan Trundell, Julian Zhou, Valerie Schlegel, Patricia Sanwald Ducray, David J Hawellek, Jonas Dorn, Cedric Simillion, Michael Lindemann, Vicki Wheelock, Alexandra Durr, Karen E Anderson, Jeffrey D Long, Edward J Wild, G Bernhard Landwehrmeyer, Blair R Leavitt, Sarah J Tabrizi, Rachelle Doody,
Tominersen in Adults with Manifest Huntington's Disease.
Nat Neurosci
Published

Age-related dysregulation of homeostatic control in neuronal microcircuits.

Authors
Carola I Radulescu, Nazanin Doostdar, Nawal Zabouri, Leire Melgosa-Ecenarro, Xingjian Wang, Sadra Sadeh, Pavlina Pavlidi, Joe Airey, Maksym Kopanitsa, Claudia Clopath, Samuel J Barnes
Age-related dysregulation of homeostatic control in neuronal microcircuits.
bioRxiv
Published

Creation of de novo cryptic splicing for ALS/FTD precision medicine.

Authors
Oscar G Wilkins, Max Z Y J Chien, Josette J Wlaschin, Maria Pisliakova, David Thompson, Holly Digby, Rebecca L Simkin, Juan Antinao Diaz, Puja R Mehta, Matthew J Keuss, Matteo Zanovello, Anna-Leigh Brown, Peter Harley, Annalucia Darbey, Rajvinder Karda, Elizabeth M C Fisher, Tom J Cunningham, Claire E Le Pichon, Jernej Ule, Pietro Fratta
Creation of de novo cryptic splicing for ALS/FTD precision medicine.