Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Science
Published

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.

Authors
Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C Saido, Sebastian Brandner, Huma Sethi, David Attwell
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Nat Protoc
Published

Derivation and maintenance of mouse haploid embryonic stem cells.

Authors
Ulrich Elling, Michael Woods, Josep V Forment, Beiyuan Fu, Fengtang Yang, Bee Ling Ng, Jose R Vicente, David J Adams, Brendan Doe, Stephen P Jackson, Josef M Penninger, Gabriel Balmus
Derivation and maintenance of mouse haploid embryonic stem cells.
PLoS Pathog
Published

The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.

Authors
Aiysha Thompson, Luke C Davies, Chia-Te Liao, Diogo M da Fonseca, James S Griffiths, Robert Andrews, Adam V Jones, Mathew Clement, Gordon D Brown, Ian R Humphreys, Philip R Taylor, Selinda J Orr
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.
Nat Rev Neurol
Published

SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.

Authors
Ross W Paterson, Audrey Gabelle, Brendan P Lucey, Nicolas R Barthélemy, Claire A Leckey, Christophe Hirtz, Sylvain Lehmann, Chihiro Sato, Bruce W Patterson, Tim West, Kevin Yarasheski, Jonathan D Rohrer, Norelle C Wildburger, Jonathan M Schott, Celeste M Karch, Selina Wray, Timothy M Miller, Donald L Elbert, Henrik Zetterberg, Nick C Fox, Randall J Bateman
SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.
N Engl J Med
Published

Targeting Huntingtin Expression in Patients with Huntington's Disease.

Authors
Sarah J Tabrizi, Blair R Leavitt, G Bernhard Landwehrmeyer, Edward J Wild, Carsten Saft, Roger A Barker, Nick F Blair, David Craufurd, Josef Priller, Hugh Rickards, Anne Rosser, Holly B Kordasiewicz, Christian Czech, Eric E Swayze, Daniel A Norris, Tiffany Baumann, Irene Gerlach, Scott A Schobel, Erika Paz, Anne V Smith, C Frank Bennett, Roger M Lane,
Targeting Huntingtin Expression in Patients with Huntington's Disease.
Nat Neurosci
Published

Central nervous system regeneration is driven by microglia necroptosis and repopulation.

Authors
Amy F Lloyd, Claire L Davies, Rebecca K Holloway, Yasmine Labrak, Graeme Ireland, Dario Carradori, Alessandra Dillenburg, Eva Borger, Daniel Soong, Jill C Richardson, Tanja Kuhlmann, Anna Williams, Jeffrey W Pollard, Anne des Rieux, Josef Priller, Veronique E Miron
Central nervous system regeneration is driven by microglia necroptosis and repopulation.
PLoS One
Published

Health management and pattern analysis of daily living activities of people with dementia using in-home sensors and machine learning techniques.

Authors
Shirin Enshaeifar, Ahmed Zoha, Andreas Markides, Severin Skillman, Sahr Thomas Acton, Tarek Elsaleh, Masoud Hassanpour, Alireza Ahrabian, Mark Kenny, Stuart Klein, Helen Rostill, Ramin Nilforooshan, Payam Barnaghi
Health management and pattern analysis of daily living activities of people with dementia using in-home sensors and machine learning techniques.