Publications

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Jul 03, 2025 - Research

Dementia is rare in midlife rugby players, but long-term risk may be increased

A study of 200 former professional rugby players (aged 30-61 years old), researchers from the UK DRI, Imperial College London and University College London (affiliated...

Learn more Dementia is rare in midlife rugby players, but long-term risk may be increased

Jun 13, 2025 - Research

Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

Researchers led by Dr Samuel Harris and Dr Marc Aurel Busche (UK DRI at UCL) have discovered that the amyloid precursor protein (APP) family, known...

Learn more Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

May 29, 2025 - Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life

Lancet

Published Jul 30, 2016

Alzheimer's disease.

Authors

Philip Scheltens, Kaj Blennow, Monique M B Breteler, Bart de Strooper, Giovanni B Frisoni, Stephen Salloway, Wiesje Maria Van der Flier

Alzheimer's disease.

Nat Neurosci

Published Jul 18, 2016

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

Authors

Alexi Nott, Jemmie Cheng, Fan Gao, Yuan-Ta Lin, Elizabeta Gjoneska, Tak Ko, Paras Minhas, Alicia Viridiana Zamudio, Jia Meng, Feiran Zhang, Peng Jin, Li-Huei Tsai

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

EMBO J

Published Jul 15, 2016

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Authors

Stefan Reber, Jolanda Stettler, Giuseppe Filosa, Martino Colombo, Daniel Jutzi, Silvia C Lenzken, Christoph Schweingruber, Rémy Bruggmann, Angela Bachi, Silvia Ml Barabino, Oliver Mühlemann, Marc-David Ruepp

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.

Mol Neurodegener

Published Jun 10, 2016

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Authors

Claire S Harwell, Michael P Coleman

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

Science

Published May 06, 2016

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Authors

Soyon Hong, Victoria F Beja-Glasser, Bianca M Nfonoyim, Arnaud Frouin, Shaomin Li, Saranya Ramakrishnan, Katherine M Merry, Qiaoqiao Shi, Arnon Rosenthal, Ben A Barres, Cynthia A Lemere, Dennis J Selkoe, Beth Stevens

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Neuron

Published Apr 20, 2016

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Authors

Sarah Veugelen, Takashi Saito, Takaomi C Saido, Lucía Chávez-Gutiérrez, Bart De Strooper

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Proc Natl Acad Sci U S A

Published Apr 12, 2016

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Authors

Uthpala Seneviratne, Alexi Nott, Vadiraja B Bhat, Kodihalli C Ravindra, John S Wishnok, Li-Huei Tsai, Steven R Tannenbaum

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Trends Neurosci

Published Mar 01, 2016

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Authors

Soraia Barão, Diederik Moechars, Stefan F Lichtenthaler, Bart De Strooper

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Cell

Published Feb 11, 2016

The Cellular Phase of Alzheimer's Disease.

Authors

Bart De Strooper, Eric Karran

The Cellular Phase of Alzheimer's Disease.

Front Neurosci

Published Jan 27, 2016

Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment.

Authors

Nathan G Skene, Seth G N Grant

Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment.

Nat Neurosci

Published Jan 18, 2016

Microglial brain region-dependent diversity and selective regional sensitivities to aging.

Authors

Kathleen Grabert, Tom Michoel, Michail H Karavolos, Sara Clohisey, J Kenneth Baillie, Mark P Stevens, Tom C Freeman, Kim M Summers, Barry W McColl

Microglial brain region-dependent diversity and selective regional sensitivities to aging.

Nat Med

Published Dec 21, 2015

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

Authors

Natura Myeku, Catherine L Clelland, Sheina Emrani, Nikolay V Kukushkin, Wai Haung Yu, Alfred L Goldberg, Karen E Duff

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

J Cell Biol

Published Oct 26, 2015

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

Authors

Tasuku Konno, Eduardo Pinho Melo, Carlos Lopes, Ilir Mehmeti, Sigurd Lenzen, David Ron, Edward Avezov

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.

Cell

Published Jul 30, 2015

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Authors

Michael J Parsons, Marco Brancaccio, Siddharth Sethi, Elizabeth S Maywood, Rahul Satija, Jessica K Edwards, Aarti Jagannath, Yvonne Couch, Mattéa J Finelli, Nicola J Smyllie, Christopher Esapa, Rachel Butler, Alun R Barnard, Johanna E Chesham, Shoko Saito, Greg Joynson, Sara Wells, Russell G Foster, Peter L Oliver, Michelle M Simon, Ann-Marie Mallon, Michael H Hastings, Patrick M Nolan

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Neuron

Published Apr 22, 2015

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.

Authors

Anne-Sophie Hafner, Andrew C Penn, Dolors Grillo-Bosch, Natacha Retailleau, Christel Poujol, Amandine Philippat, Françoise Coussen, Matthieu Sainlos, Patricio Opazo, Daniel Choquet

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.

Nature

Published Feb 12, 2015

Grid cell symmetry is shaped by environmental geometry.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, Caswell Barry, John O'Keefe

Grid cell symmetry is shaped by environmental geometry.

Nat Protoc

Published Jan 10, 2015

A high-throughput in vivo micronucleus assay for genome instability screening in mice.

Authors

Gabriel Balmus, Natasha A Karp, Bee Ling Ng, Stephen P Jackson, David J Adams, Rebecca E McIntyre

A high-throughput in vivo micronucleus assay for genome instability screening in mice.

BMC Biol

Published Jan 10, 2015

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

Authors

Edward Avezov, Tasuku Konno, Alisa Zyryanova, Weiyue Chen, Romain Laine, Ana Crespillo-Casado, Eduardo Pinho Melo, Ryo Ushioda, Kazuhiro Nagata, Clemens F Kaminski, Heather P Harding, David Ron

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.