Publications

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Jul 03, 2025 - Research

Dementia is rare in midlife rugby players, but long-term risk may be increased

A study of 200 former professional rugby players (aged 30-61 years old), researchers from the UK DRI, Imperial College London and University College London (affiliated...

Learn more Dementia is rare in midlife rugby players, but long-term risk may be increased

Jun 13, 2025 - Research

Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

Researchers led by Dr Samuel Harris and Dr Marc Aurel Busche (UK DRI at UCL) have discovered that the amyloid precursor protein (APP) family, known...

Learn more Essential Alzheimer’s-linked proteins found to sustain healthy brain activity

May 29, 2025 - Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life

J Neurosci

Published Nov 12, 2014

Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back.

Authors

Marco Brancaccio, Ryosuke Enoki, Cristina N Mazuski, Jeff Jones, Jennifer A Evans, Abdelhalim Azzi

Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back.

Cell

Published Nov 06, 2014

Lessons from a failed γ-secretase Alzheimer trial.

Authors

Bart De Strooper

Lessons from a failed γ-secretase Alzheimer trial.

Science

Published Sep 05, 2014

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Authors

Sarah Mizielinska, Sebastian Grönke, Teresa Niccoli, Charlotte E Ridler, Emma L Clayton, Anny Devoy, Thomas Moens, Frances E Norona, Ione O C Woollacott, Julian Pietrzyk, Karen Cleverley, Andrew J Nicoll, Stuart Pickering-Brown, Jacqueline Dols, Melissa Cabecinha, Oliver Hendrich, Pietro Fratta, Elizabeth M C Fisher, Linda Partridge, Adrian M Isaacs

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Science

Published Aug 01, 2014

Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function.

Authors

Hua Hu, Jian Gan, Peter Jonas

Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function.

Neuron

Published May 21, 2014

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

Authors

Tara L Spires-Jones, Bradley T Hyman

The intersection of amyloid beta and tau at synapses in Alzheimer's disease.

Science

Published May 09, 2014

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Authors

Marcela Rosas, Luke C Davies, Peter J Giles, Chia-Te Liao, Bashar Kharfan, Timothy C Stone, Valerie B O'Donnell, Donald J Fraser, Simon A Jones, Philip R Taylor

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

Neuron

Published Apr 16, 2014

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Authors

Soyon Hong, Beth L Ostaszewski, Ting Yang, Tiernan T O'Malley, Ming Jin, Katsuhiko Yanagisawa, Shaomin Li, Tim Bartels, Dennis J Selkoe

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Science

Published Apr 11, 2014

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Authors

Vanessa A Morais, Dominik Haddad, Katleen Craessaerts, Pieter-Jan De Bock, Jef Swerts, Sven Vilain, Liesbeth Aerts, Lut Overbergh, Anne Grünewald, Philip Seibler, Christine Klein, Kris Gevaert, Patrik Verstreken, Bart De Strooper

PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.

Nature

Published Apr 03, 2014

Capillary pericytes regulate cerebral blood flow in health and disease.

Authors

Catherine N Hall, Clare Reynell, Bodil Gesslein, Nicola B Hamilton, Anusha Mishra, Brad A Sutherland, Fergus M O'Farrell, Alastair M Buchan, Martin Lauritzen, David Attwell

Capillary pericytes regulate cerebral blood flow in health and disease.

N Engl J Med

Published Mar 27, 2014

Thrombotic microangiopathy associated with interferon beta.

Authors

David Hunt, David Kavanagh, Iain Drummond, Belinda Weller, Chris Bellamy, James Overell, Stephen Evans, Andrew Jackson, Siddharthan Chandran

Thrombotic microangiopathy associated with interferon beta.

Nat Neurosci

Published Feb 24, 2014

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.

Authors

Usman A Khan, Li Liu, Frank A Provenzano, Diego E Berman, Caterina P Profaci, Richard Sloan, Richard Mayeux, Karen E Duff, Scott A Small

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.

Philos Trans R Soc Lond B Biol Sci

Published Feb 05, 2014

How environment geometry affects grid cell symmetry and what we can learn from it.

Authors

Julija Krupic, Marius Bauza, Stephen Burton, Colin Lever, John O'Keefe

How environment geometry affects grid cell symmetry and what we can learn from it.

N Engl J Med

Published Jan 23, 2014

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Authors

Stephen Salloway, Reisa Sperling, Nick C Fox, Kaj Blennow, William Klunk, Murray Raskind, Marwan Sabbagh, Lawrence S Honig, Anton P Porsteinsson, Steven Ferris, Marcel Reichert, Nzeera Ketter, Bijan Nejadnik, Volkmar Guenzler, Maja Miloslavsky, Daniel Wang, Yuan Lu, Julia Lull, Iulia Cristina Tudor, Enchi Liu, Michael Grundman, Eric Yuen, Ronald Black, H Robert Brashear,

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.

Acta Neuropathol

Published Oct 30, 2013

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Authors

Sarah Mizielinska, Tammaryn Lashley, Frances E Norona, Emma L Clayton, Charlotte E Ridler, Pietro Fratta, Adrian M Isaacs

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.

Nat Neurosci

Published Jul 21, 2013

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Authors

Veronique E Miron, Amanda Boyd, Jing-Wei Zhao, Tracy J Yuen, Julia M Ruckh, Jennifer L Shadrach, Peter van Wijngaarden, Amy J Wagers, Anna Williams, Robin J M Franklin, Charles Ffrench-Constant

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Brain

Published Jul 18, 2013

The role of the posterior cingulate cortex in cognition and disease.

Authors

Robert Leech, David J Sharp

The role of the posterior cingulate cortex in cognition and disease.

Nat Commun

Published May 21, 2013

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

Authors

Luke C Davies, Marcela Rosas, Stephen J Jenkins, Chia-Te Liao, Martin J Scurr, Frank Brombacher, Donald J Fraser, Judith E Allen, Simon A Jones, Philip R Taylor

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation.

J Cell Biol

Published Apr 15, 2013

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

Authors

Edward Avezov, Benedict C S Cross, Gabriele S Kaminski Schierle, Mikael Winters, Heather P Harding, Eduardo Pinho Melo, Clemens F Kaminski, David Ron

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.