Publications

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Jan 28, 2026 - Research

Targeting the gut's immune system could tackle early stages of Parkinson's

New research, led by Dr Soyon Hong and Dr Tim Bartels at the UK DRI at UCL, has revealed how Parkinson’s spreads from the gut...

Learn more Targeting the gut's immune system could tackle early stages of Parkinson's

Cytokines released by T cells after encountering cancer cells

Jan 23, 2026

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system

Jan 14, 2026 - Research

Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

New research led by Dr Maura Malpetti and Noah Shapiro (UK DRI at Cambridge) reveals signs of brain shrinkage, inflammation and blood markers for nerve...

Learn more Brain shrinkage and inflammation predict disease progression in progressive supranuclear palsy

Sci Adv

Published Oct 29, 2021

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.

Authors

Georg Meisl, Eric Hidari, Kieren Allinson, Timothy Rittman, Sarah L DeVos, Justin S Sanchez, Catherine K Xu, Karen E Duff, Keith A Johnson, James B Rowe, Bradley T Hyman, Tuomas P J Knowles, David Klenerman

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.

Sci Adv

Published Oct 29, 2021

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.

Authors

In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.

Brain Commun

Published Oct 23, 2021

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective.

Authors

Charis Wong, Maria Stavrou, Elizabeth Elliott, Jenna M Gregory, Nigel Leigh, Ashwin A Pinto, Timothy L Williams, Jeremy Chataway, Robert Swingler, Mahesh K B Parmar, Nigel Stallard, Christopher J Weir, Richard A Parker, Amina Chaouch, Hisham Hamdalla, John Ealing, George Gorrie, Ian Morrison, Callum Duncan, Peter Connelly, Francisco Javier Carod-Artal, Richard Davenport, Pablo Garcia Reitboeck, Aleksandar Radunovic, Venkataramanan Srinivasan, Jenny Preston, Arpan R Mehta, Danielle Leighton, Stella Glasmacher, Emily Beswick, Jill Williamson, Amy Stenson, Christine Weaver, Judith Newton, Dawn Lyle, Rachel Dakin, Malcolm Macleod, Suvankar Pal, Siddharthan Chandran

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective.

J Cereb Blood Flow Metab

Published Oct 19, 2021

Cerebral cortical microinfarcts in patients with internal carotid artery occlusion.

Authors

Hilde van den Brink, Doeschka A Ferro, Jeroen de Bresser, Esther E Bron, Laurien P Onkenhout, L Jaap Kappelle, Geert Jan Biessels

Cerebral cortical microinfarcts in patients with internal carotid artery occlusion.

Neuroscience

Published Oct 15, 2021

Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia.

Authors

Audrey Chagnot, Samuel R Barnes, Axel Montagne

Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia.

Neuroscience

Published Oct 15, 2021

Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia.

Authors

Audrey Chagnot, Samuel R Barnes, Axel Montagne

Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia.

Science

Published Oct 15, 2021

Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed.

Authors

Jonathan Lezmy, I Lorena Arancibia-Cárcamo, Tania Quintela-López, Diane L Sherman, Peter J Brophy, David Attwell

Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed.

Science

Published Oct 15, 2021

Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed.

Authors

Jonathan Lezmy, I Lorena Arancibia-Cárcamo, Tania Quintela-López, Diane L Sherman, Peter J Brophy, David Attwell

Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed.

Wellcome Open Res

Published Oct 13, 2021

Rapid design and implementation of an adaptive pooling workflow for SARS-CoV-2 testing in an NHS diagnostic laboratory: a proof-of-concept study.

Authors

Michael Crone, Paul Randell, Zoey Herm, Arthi Anand, Saghar Missaghian-Cully, Loren Perelman, Panagiotis Pantelidis, Paul Freemont

Rapid design and implementation of an adaptive pooling workflow for SARS-CoV-2 testing in an NHS diagnostic laboratory: a proof-of-concept study.

Nat Neurosci

Published Oct 08, 2021

Neuroinflammatory astrocyte subtypes in the mouse brain.

Authors

Philip Hasel, Indigo V L Rose, Jessica S Sadick, Rachel D Kim, Shane A Liddelow

Neuroinflammatory astrocyte subtypes in the mouse brain.

Cell Stem Cell

Published Oct 07, 2021

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Authors

Hannah Walgrave, Sriram Balusu, Sarah Snoeck, Elke Vanden Eynden, Katleen Craessaerts, Nicky Thrupp, Leen Wolfs, Katrien Horré, Yannick Fourne, Alicja Ronisz, Edina Silajdžić, Amber Penning, Giorgia Tosoni, Zsuzsanna Callaerts-Vegh, Rudi D'Hooge, Dietmar Rudolf Thal, Henrik Zetterberg, Sandrine Thuret, Mark Fiers, Carlo Sala Frigerio, Bart De Strooper, Evgenia Salta

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Cell Stem Cell

Published Oct 07, 2021

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Authors

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease.

Cells

Published Oct 06, 2021

IKK2/NF-κB Activation in Astrocytes Reduces amyloid β Deposition: A Process Associated with Specific Microglia Polarization.

Authors

Shu Yang, Alexander Magnutzki, Najwa Ouali Alami, Michael Lattke, Tabea Melissa Hein, Judith Stefanie Scheller, Carsten Kröger, Franz Oswald, Deniz Yilmazer-Hanke, Thomas Wirth, Bernd Baumann

IKK2/NF-κB Activation in Astrocytes Reduces amyloid β Deposition: A Process Associated with Specific Microglia Polarization.

J Neuroinflammation

Published Oct 03, 2021

Differential chemokine alteration in the variants of primary progressive aphasia-a role for neuroinflammation.

Authors

Aitana Sogorb-Esteve, Imogen J Swift, Ione O C Woollacott, Jason D Warren, Henrik Zetterberg, Jonathan D Rohrer

Differential chemokine alteration in the variants of primary progressive aphasia-a role for neuroinflammation.

IEEE Trans Neural Netw Learn Syst

Published Sep 29, 2021

Continual Learning Using Bayesian Neural Networks.

Authors

Honglin Li, Payam Barnaghi, Shirin Enshaeifar, Frieder Ganz

Continual Learning Using Bayesian Neural Networks.

Brain Lang

Published Sep 25, 2021

Machine learning accurately classifies neural responses to rhythmic speech vs. non-speech from 8-week-old infant EEG.

Authors

Samuel Gibbon, Adam Attaheri, Áine Ní Choisdealbha, Sinead Rocha, Perrine Brusini, Natasha Mead, Panagiotis Boutris, Helen Olawole-Scott, Henna Ahmed, Sheila Flanagan, Kanad Mandke, Mahmoud Keshavarzi, Usha Goswami

Machine learning accurately classifies neural responses to rhythmic speech vs. non-speech from 8-week-old infant EEG.

Brain Behav Immun

Published Sep 17, 2021

Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.

Authors

Laura J Westacott, Trevor Humby, Niels Haan, Sophie A Brain, Emma-Louise Bush, Margarita Toneva, Andreea-Ingrid Baloc, Anna L Moon, Jack Reddaway, Michael J Owen, Jeremy Hall, Timothy R Hughes, B Paul Morgan, William P Gray, Lawrence S Wilkinson

Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.

J Struct Biol

Published Sep 01, 2021

Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2.

Authors

Antonette Bennett, Joshua Hull, Nelly Jolinon, Julie Tordo, Katie Moss, Enswert Binns, Mario Mietzsch, Cathleen Hagemann, R Michael Linden, Andrea Serio, Paul Chipman, Duncan Sousa, Felix Broecker, Peter Seeberger, Els Henckaerts, Robert McKenna, Mavis Agbandje-McKenna

Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2.