Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Alzheimer's research & therapy
Published
Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes
Authors
Mario Tranfa, Leonard Pieperhoff, Giuseppe Pontillo, Emma S Luckett, Lyduine E Collij, Tiago Gil Oliveira, Niccoló Tesi, Natalia Vilor-Tejedor, André Altmann, Luca Roccatagliata, Matteo Pardini, Henne Holstege, Marcel Reinders, Pierre Payoux, Pablo Martinez-Lage, Craig W Ritchie, Adam Waldman, Joanna M Wardlaw, Juan Domingo Gispert, Gemma Salvadó, Arturo Brunetti, Henk J M M Mutsaerts, Alle Meije Wink, Frederik Barkhof, Luigi Lorenzini
Polygenic pathways shape white matter vulnerability to Alzheimer's disease-related pathophysiological changes
Journal of neurotrauma
Published
Diffusion Alterations at the Gray Matter/White Matter Boundary in Traumatic Encephalopathy Syndrome
Authors
Tim L T Wiegand, Lara Pankatz, Hector Arciniega, Leonard B Jung, Fatima Tuz-Zahra, Sylvain Bouix, Haley Lubeck, Philine Rojczyk, Luisa S Schuhmacher, Janna Buring, Douglas I Katz, Yorghos Tripodis, Ofer Pasternak, Suheyla Cetin-Karayumak, Yogesh Rathi, Charles H Adler, Ann C McKee, Laura J Balcer, Charles Bernick, Michael J Coleman, Elizabeth A Colasurdo, Alexander P Lin, Elaine R Peskind, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Michael L Alosco, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Inga K Koerte, DIAGNOSE CTE Research Project
Diffusion Alterations at the Gray Matter/White Matter Boundary in Traumatic Encephalopathy Syndrome
European journal of neurology
Published
Miglustat in Alzheimer's Disease Associated With Heterozygous NPC1 Mutation: Exploratory Case Series and Preliminary Findings
Authors
Diego Lopergolo, Daniele Gasparini, Silvia Bianchi, Barbara Pucci, Domenico Tripodi, Valerio Leoni, Andrea Chincarini, Stelvio Sestini, Henrik Zetterberg, Nicola De Stefano, Andrea Mignarri
Miglustat in Alzheimer's Disease Associated With Heterozygous NPC1 Mutation: Exploratory Case Series and Preliminary Findings
Nature communications
Published
Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome
Authors
Hanna Huber, Javier Arranz, Burak Arslan, Antoine Leuzy, Oscar Kittel, Guglielmo di Molfetta, Bessy Benejam, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Lucía Maure-Blesa, Íñigo Rodríguez-Baz, José Enrique Arriola Infante, Ignacio Illán-Gala, Alexandre Bejanin, Laia Montoliu-Gaya, Alberto Lleó, María Carmona-Iragui, Daniel Alcolea, Kaj Blennow, Henrik Zetterberg, Juan Fortea, Nicholas J Ashton
Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome
Journal of internal medicine
Published
Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health
Authors
Silvia Maioli, Ivan Nalvarte, Maria Ankarcrona, Marianne Schultzberg, Kristen L Zuloaga, Julen Goikolea, Pieter Jelle Visser, Bart De Strooper, Bengt Winblad, Paola Pizzo, Pete A Williams, Patricia Rodriguez-Rodriguez, Luana Naia
Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health
Nature neuroscience
Published
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease
Authors
João Pedro Ferrari-Souza, Guilherme Povala, Nesrine Rahmouni, Bruna Bellaver, Pamela C L Ferreira, Marco Antônio De Bastiani, Douglas T Leffa, Firoza Z Lussier, Cristiano S Aguzzoli, Wagner S Brum, Giovanna Carello-Collar, Wyllians V Borelli, Joseph Therriault, Arthur C Macedo, Stijn Servaes, Jenna Stevenson, Ilaria Pola, Serge Gauthier, Diogo O Souza, Lucas Porcello Schilling, Mychael V Lourenco, Gallen Triana-Baltzer, Hartmuth C Kolb, Andréa L Benedet, Nicholas J Ashton, Dana L Tudorascu, Henrik Zetterberg, Kaj Blennow, Sterling C Johnson, Tharick A Pascoal, Pedro Rosa-Neto, Eduardo R Zimmer
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease
The Journal of biological chemistry
Published
Cellular and functional insights into FIH-mediated hydroxylation of TRPA1
Authors
Tao Guo, Dianne Marquez Lopez, Siyuan Wang, Liudi Yao, Xi Li, Elizabeth R Davies, Mariana Vargas-Caballero, Nullin Divecha, Christopher J Schofield, Katrin Deinhardt, Yihua Wang
Cellular and functional insights into FIH-mediated hydroxylation of TRPA1
Nature communications
Published
Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
Authors
Steven A Hill, Isabel Bravo-Ferrer, Austėja Čiulkinytė, Noelia Pérez Ramos, Ilaria Rossetti, Chiara Colvin, Paula Beltran-Lobo, Carlos Parra-Pérez, Katie Emelianova, Owen Dando, Beth Geary, Raja S Nirujogi, Dario R Alessi, Do-Young Lee, Youn-Bok Lee, Blanca Díaz Castro
Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
Multiple sclerosis (Houndmills, Basingstoke, England)
Published
Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
Authors
Sofia Sandgren, Aleksandra Maleska Maceski, Pascal Benkert, Maximilian Einsiedler, Sabine Schaedelin, Johanna Oechtering, Lutz Achtnichts, Patrice H Lalive, Stefanie Müller, Caroline Pot, Amanda Heslegrave, David Hunt, Jan Lycke, Robert Hoepner, Patrick Roth, Claudio Gobbi, Manuel Comabella, Tobias Derfuss, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline Aj Willemse, Henrik Zetterberg, Jens Kuhle
Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
Neurology
Published
In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy: An Exploratory Study
Authors
Hilde van den Brink, Mariel G Kozberg, Nazanin Makkinejad, John E Kirsch, Michael J Thrippleton, Thijs W van Harten, Sabine Voigt, Whitney M Freeze, Matthias J P Van Osch, Anand Viswanathan, Susanne J van Veluw
In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy: An Exploratory Study
Molecular medicine (Cambridge, Mass.)
Published
Syntaphilin loss enhances mitochondrial axonal transport and neuromuscular junction formation in a human stem cell derived neuromuscular assembloid model
Authors
Andrea Salzinger, Esra Özkan, Vidya Ramesh, Jyoti Nanda, Karen Burr, David Story, Nhan T Pham, Siddharthan Chandran, Bhuvaneish T Selvaraj
Syntaphilin loss enhances mitochondrial axonal transport and neuromuscular junction formation in a human stem cell derived neuromuscular assembloid model
Brain : a journal of neurology
Published
Estimating the time course of biomarker changes in Alzheimer's disease
Authors
Lars Lau Raket, Alexa Pichet Binette, Niklas Mattsson-Carlgren, Shorena Janelidze, Henrik Zetterberg, Nicholas J Ashton, Kaj Blennow, Erik Stomrud, Sebastian Palmqvist, Oskar Hansson
Estimating the time course of biomarker changes in Alzheimer's disease
Translational psychiatry
Published
Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures
Authors
Joanna E Moodie, Colin R Buchanan, Anna E Fürtjes, Eleanor L S Conole, Aleks Stolicyn, Janie Corley, Karen Ferguson, Maria Valdés Hernández, Susana Muñoz Maniega, Tom C Russ, Michelle Luciano, Heather Whalley, Mark E Bastin, Joanna Wardlaw, Ian J Deary, Simon R Cox
Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures