Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Cell reports
Published

Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics

Authors
Anna Mallach, Magdalena Zielonka, Veerle van Lieshout, Yanru An, Jia Hui Khoo, Marisa Vanheusden, Wei-Ting Chen, Daan Moechars, I Lorena Arancibia-Carcamo, Mark Fiers, Bart De Strooper
Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics
Science (New York, N.Y.)
Published

Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease

Authors
Katrien Princen, Tom Van Dooren, Marit van Gorsel, Nikolaos Louros, Xiaojuan Yang, Michael Dumbacher, Ilse Bastiaens, Kristel Coupet, Shana Dupont, Eva Cuveliers, Annick Lauwers, Mohamed Laghmouchi, Thomas Vanwelden, Sofie Carmans, Nele Van Damme, Hein Duhamel, Seppe Vansteenkiste, Jovan Prerad, Karolien Pipeleers, Olivier Rodiers, Liese De Ridder, Sofie Claes, Yoni Busschots, Lentel Pringels, Vanessa Verhelst, Eveline Debroux, Marinka Brouwer, Sam Lievens, Jan Tavernier, Melissa Farinelli, Sandrine Hughes-Asceri, Marieke Voets, Joris Winderickx, Stefaan Wera, Joris de Wit, Joost Schymkowitz, Frederic Rousseau, Henrik Zetterberg, Jeffrey L Cummings, Wim Annaert, Tom Cornelissen, Hans De Winter, Koen De Witte, Marc Fivaz, Gerard Griffioen
Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease
Molecular psychiatry
Published

Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease

Authors
Quentin Le Grand, Ami Tsuchida, Alexandra Koch, Mohammed-Aslam Imtiaz, N Ahmad Aziz, Chloé Vigneron, Laure Zago, Mark Lathrop, Alexandre Dubrac, Thierry Couffinhal, Fabrice Crivello, Paul M Matthews, Aniket Mishra, Monique M B Breteler, Christophe Tzourio, Stéphanie Debette
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3

Authors
Daniel J Panyard, Lianne M Reus, Muhammad Ali, Jihua Liu, Yuetiva K Deming, Qiongshi Lu, Gwendlyn Kollmorgen, Margherita Carboni, Norbert Wild, Pieter J Visser, Lars Bertram, Henrik Zetterberg, Kaj Blennow, Johan Gobom, Dan Western, Yun Ju Sung, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Carlos Cruchaga, Betty M Tijms, Corinne D Engelman, Michael P Snyder
Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3
PloS one
Published

Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam)

Authors
Howard H Feldman, José A Luchsinger, Gabriel C Léger, Curtis Taylor, Diane M Jacobs, David P Salmon, Steven D Edland, Karen Messer, Carolyn Revta, Sarah A Flowers, Kerry S Jones, Albert Koulman, Kevin E Yarasheski, Philip B Verghese, Venky Venkatesh, Henrik Zetterberg, January Durant, Jody-Lynn Lupo, Gary E Gibson, ADCS BenfoTeam Study Group
Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam)
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects

Authors
Adrienne Biskaduros, Lidia Glodzik, Leslie A Saint Louis, Henry Rusinek, Elizabeth Pirraglia, Ricardo Osorio, Tracy Butler, Yi Li, Ke Xi, Emily Tanzi, Patrick Harvey, Henrik Zetterberg, Kaj Blennow, Mony J de Leon
Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects
Translational neurodegeneration
Published

The relation of synaptic biomarkers with Aβ, tau, glial activation, and neurodegeneration in Alzheimer's disease

Authors
Yi-Ting Wang, Nicholas J Ashton, Stijn Servaes, Johanna Nilsson, Marcel S Woo, Tharick A Pascoal, Cécile Tissot, Nesrine Rahmouni, Joseph Therriault, Firoza Lussier, Mira Chamoun, Serge Gauthier, Ann Brinkmalm, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Andréa L Benedet
The relation of synaptic biomarkers with Aβ, tau, glial activation, and neurodegeneration in Alzheimer's disease
Therapeutic advances in neurological disorders
Published

Differential risk factor profile and neuroimaging markers of small vessel disease between lacunar ischemic stroke and deep intracerebral hemorrhage

Authors
Yajun Cheng, Maria Del C Valdés Hernández, Mangmang Xu, Shuting Zhang, Xiaohua Pan, Baoqiang An, Joanna M Wardlaw, Ming Liu, Bo Wu
Differential risk factor profile and neuroimaging markers of small vessel disease between lacunar ischemic stroke and deep intracerebral hemorrhage
Cell reports
Published

The neuron mixer and its impact on human brain dynamics

Authors
Charlotte E Luff, Robert Peach, Emma-Jane Mallas, Edward Rhodes, Felix Laumann, Edward S Boyden, David J Sharp, Mauricio Barahona, Nir Grossman
The neuron mixer and its impact on human brain dynamics