Publications

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Jan 17, 2025 - Research

Brain changes in Huntington’s disease occur decades before diagnosis

Subtle changes in the brain happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s disease, finds a new study led by...

Learn more Brain changes in Huntington’s disease occur decades before diagnosis

Jan 08, 2025 - Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s

Phospho-tau accumulation in MAPT knockout mice

Jan 08, 2025 - Research

Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

A new study led by Prof Karen Duff, Dr Naoto Watamura, and Dr Martha Foiani (UK DRI at UCL), with Prof Takaomi Saido (Riken Center...

Learn more Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

Exp Cell Res

Published Jul 15, 2022

Bioengineering human skeletal muscle models: Recent advances, current challenges and future perspectives.

Authors

Yunsong Jiang, Tugce Torun, Sara M Maffioletti, Andrea Serio, Francesco Saverio Tedesco

Bioengineering human skeletal muscle models: Recent advances, current challenges and future perspectives.

Nat Neurosci

Published Jul 14, 2022

Identification of early neurodegenerative pathways in progressive multiple sclerosis.

Authors

Max Kaufmann, Anna-Lena Schaupp, Rosa Sun, Fabian Coscia, Calliope A Dendrou, Adrian Cortes, Gurman Kaur, Hayley G Evans, Annelie Mollbrink, José Fernández Navarro, Jana K Sonner, Christina Mayer, Gabriele C DeLuca, Joakim Lundeberg, Paul M Matthews, Kathrine E Attfield, Manuel A Friese, Matthias Mann, Lars Fugger

Identification of early neurodegenerative pathways in progressive multiple sclerosis.

ACS Appl Mater Interfaces

Published Jul 13, 2022

Biophysical Regulations of Epigenetic State and Notch Signaling in Neural Development Using Microgroove Substrates.

Authors

Chia-Chen Hsu, Andrea Serio, Sahana Gopal, Amy Gelmi, Ciro Chiappini, Ravi A Desai, Molly M Stevens

Biophysical Regulations of Epigenetic State and Notch Signaling in Neural Development Using Microgroove Substrates.

Cell Death Dis

Published Jul 07, 2022

Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons.

Authors

Elena R Rhymes, Andrew P Tosolini, Alexander D Fellows, William Mahy, Neil Q McDonald, Giampietro Schiavo

Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons.

Acta Neuropathol Commun

Published Jul 06, 2022

Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.

Authors

Sarah M Carpanini, Megan Torvell, Ryan J Bevan, Robert A J Byrne, Nikoleta Daskoulidou, Takashi Saito, Takaomi C Saido, Philip R Taylor, Timothy R Hughes, Wioleta M Zelek, B Paul Morgan

Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.

Science

Published Jun 30, 2022

A specific circuit in the midbrain detects stress and induces restorative sleep.

Authors

Xiao Yu, Guangchao Zhao, Dan Wang, Sa Wang, Rui Li, Ao Li, Huan Wang, Mathieu Nollet, You Young Chun, Tianyuan Zhao, Raquel Yustos, Huiming Li, Jianshuai Zhao, Jiannan Li, Min Cai, Alexei L Vyssotski, Yulong Li, Hailong Dong, Nicholas P Franks, William Wisden

A specific circuit in the midbrain detects stress and induces restorative sleep.

STAR Protoc

Published Jun 17, 2022

Cell-specific RNA purification to study translatomes of mouse central nervous system.

Authors

Isabel Bravo-Ferrer, Baljit S Khakh, Blanca Díaz-Castro

Cell-specific RNA purification to study translatomes of mouse central nervous system.

Front Comput Neurosci

Published Jun 16, 2022

Recent Trends in Non-invasive Neural Recording Based Brain-to-Brain Synchrony Analysis on Multidisciplinary Human Interactions for Understanding Brain Dynamics: A Systematic Review.

Authors

Tahnia Nazneen, Iffath Binta Islam, Md Sakibur Rahman Sajal, Wasifa Jamal, M Ashraful Amin, Ravi Vaidyanathan, Tom Chau, Khondaker A Mamun

Recent Trends in Non-invasive Neural Recording Based Brain-to-Brain Synchrony Analysis on Multidisciplinary Human Interactions for Understanding Brain Dynamics: A Systematic Review.

Cell Stem Cell

Published Jun 02, 2022

Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.

Authors

Lucia S Capano, Chihiro Sato, Elena Ficulle, Anan Yu, Kanta Horie, Ji-Sun Kwon, Kyle F Burbach, Nicolas R Barthélemy, Susan G Fox, Celeste M Karch, Randall J Bateman, Henry Houlden, Richard I Morimoto, David M Holtzman, Karen E Duff, Andrew S Yoo

Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.

Neuron

Published Jun 01, 2022

Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease.

Authors

Jessica S Sadick, Michael R O'Dea, Philip Hasel, Taitea Dykstra, Arline Faustin, Shane A Liddelow

Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease.

Dis Model Mech

Published Jun 01, 2022

Deep phenotyping for precision medicine in Parkinson's disease.

Authors

Ann-Kathrin Schalkamp, Nabila Rahman, Jimena Monzón-Sandoval, Cynthia Sandor

Deep phenotyping for precision medicine in Parkinson's disease.

Acta Neuropathol

Published May 30, 2022

Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.

Authors

Sophie Quick, Tessa V Procter, Jonathan Moss, Luise Seeker, Marc Walton, Angus Lawson, Serena Baker, Anna Beletski, Daniela Jaime Garcia, Mehreen Mohammad, William Mungall, Ami Onishi, Zuzanna Tobola, Michael Stringer, Maurits A Jansen, Antoine Vallatos, Ylenia Giarratano, Miguel O Bernabeu, Joanna M Wardlaw, Anna Williams

Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.

Front Hum Neurosci

Published May 26, 2022

BCI-Based Consumers' Choice Prediction From EEG Signals: An Intelligent Neuromarketing Framework.

Authors

Fazla Rabbi Mashrur, Khandoker Mahmudur Rahman, Mohammad Tohidul Islam Miya, Ravi Vaidyanathan, Syed Ferhat Anwar, Farhana Sarker, Khondaker A Mamun

BCI-Based Consumers' Choice Prediction From EEG Signals: An Intelligent Neuromarketing Framework.

Brain Commun

Published May 17, 2022

Genome-wide association studies for Alzheimer's disease: bigger is not always better.

Authors

Valentina Escott-Price, John Hardy

Genome-wide association studies for Alzheimer's disease: bigger is not always better.

Alzheimers Dement (Amst)

Published May 16, 2022

Night-to-night variation in sleep associates with day-to-day variation in vigilance, cognition, memory, and behavioral problems in Alzheimer's disease.

Authors

Sara Balouch, Dylan A D Dijk, Jennifer Rusted, Simon S Skene, Naji Tabet, Derk-Jan Dijk

Night-to-night variation in sleep associates with day-to-day variation in vigilance, cognition, memory, and behavioral problems in Alzheimer's disease.

Nat Commun

Published May 16, 2022

Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses.

Authors

Jonathan X Meng, Yu Zhang, Dominik Saman, Arshad M Haider, Suman De, Jason C Sang, Karen Brown, Kun Jiang, Jane Humphrey, Linda Julian, Eric Hidari, Steven F Lee, Gabriel Balmus, R Andres Floto, Clare E Bryant, Justin L P Benesch, Yu Ye, David Klenerman

Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses.

Cell Rep

Published May 03, 2022

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Authors

Benjamin J Tuck, Lauren V C Miller, Taxiarchis Katsinelos, Annabel E Smith, Emma L Wilson, Sophie Keeling, Shi Cheng, Marina J Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C James, William A McEwan

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Exp Neurol

Published May 01, 2022

DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.

Authors

Mayela Zamora, Robert Toth, Francesca Morgante, Jon Ottaway, Tom Gillbe, Sean Martin, Guy Lamb, Tara Noone, Moaad Benjaber, Zachary Nairac, Devang Sehgal, Timothy G Constandinou, Jeffrey Herron, Tipu Z Aziz, Ivor Gillbe, Alexander L Green, Erlick A C Pereira, Timothy Denison

DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.