Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Molecular neurodegeneration
Published

Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting

Authors
Xuemei Zeng, Yijun Chen, Anuradha Sehrawat, Jihui Lee, Tara K Lafferty, Julia Kofler, Sarah B Berman, Robert A Sweet, Dana L Tudorascu, William E Klunk, Milos D Ikonomovic, Anna Pfister, Henrik Zetterberg, Beth E Snitz, Anne D Cohen, Victor L Villemagne, Tharick A Pascoal, M Llyas Kamboh, Oscar I Lopez, Kaj Blennow, Thomas K Karikari
Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting
Nature neuroscience
Published

Brain clearance is reduced during sleep and anesthesia

Authors
Andawei Miao, Tianyuan Luo, Bryan Hsieh, Christopher J Edge, Morgan Gridley, Ryan Tak Chun Wong, Timothy G Constandinou, William Wisden, Nicholas P Franks
Brain clearance is reduced during sleep and anesthesia
Diagnostics (Basel, Switzerland)
Published

Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age-Results from the Multicentre Observational DELCODE Study

Authors
Marc Dörner, Katharina Seebach, Michael T Heneka, Inga Menze, Roland von Känel, Sebastian Euler, Frank Schreiber, Philipp Arndt, Katja Neumann, Annkatrin Hildebrand, Anna-Charlotte John, Anthony Tyndall, Johannes Kirchebner, Pawel Tacik, Robin Jansen, Alexander Grimm, Solveig Henneicke, Valentina Perosa, Sven G Meuth, Oliver Peters, Julian Hellmann-Regen, Lukas Preis, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Jan Ben Schulze, Sarah Lavinia Florence Schiebler, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy-Kluth, Michael Wagner, Ingo Frommann, Falk Lüsebrink, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Luca Kleineidam, Melina Stark, Matthias Schmid, Ersin Ersözlü, Frederic Brosseron, Michael Ewers, Björn H Schott, Emrah Düzel, Gabriel Ziegler, Hendrik Mattern, Stefanie Schreiber, Jose Bernal
Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age-Results from the Multicentre Observational DELCODE Study
International journal of molecular sciences
Published

A Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1

Authors
Gustaf Gadd, Daniel Åberg, Alexander Wall, Henrik Zetterberg, Kaj Blennow, Katarina Jood, Christina Jern, Jörgen Isgaard, Johan Svensson, N David Åberg
A Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1
Brain communications
Published

Impact of long-term white matter hyperintensity changes on mobility and dexterity

Authors
Angela C C Jochems, Susana Muñoz Maniega, Francesca M Chappell, Una Clancy, Carmen Arteaga, Daniela Jaime Garcia, Olivia K L Hamilton, Will Hewins, Rachel Locherty, Ellen V Backhouse, Gayle Barclay, Charlotte Jardine, Donna McIntyre, Iona Gerrish, Yajun Cheng, Xiaodi Liu, Junfang Zhang, Agniete Kampaite, Eleni Sakka, Maria Valdés Hernández, Stewart Wiseman, Michael S Stringer, Michael J Thrippleton, Fergus N Doubal, Joanna M Wardlaw
Impact of long-term white matter hyperintensity changes on mobility and dexterity
Brain communications
Published

CSF neurofilament light chain profiling and quantitation in neurological diseases

Authors
Claire A Leckey, John B Coulton, Tatiana A Giovannucci, Yingxin He, Aram Aslanyan, Rhiannon Laban, Amanda Heslegrave, Ivan Doykov, Francesca Ammoscato, Jeremy Chataway, Floriana De Angelis, Sharmilee Gnanapavan, Lauren M Byrne, Jonathan M Schott, Edward J Wild, Nicolas R Barthelémy, Henrik Zetterberg, Selina Wray, Randall J Bateman, Kevin Mills, Ross W Paterson
CSF neurofilament light chain profiling and quantitation in neurological diseases
Communications biology
Published

Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer's disease

Authors
Lazaro M Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Thomas K Karikari, Nicholas J Ashton, Andréa L Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C Kolb, Pedro Rosa-Neto, Yasser Iturria-Medina
Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer's disease
Brain : a journal of neurology
Published

Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia

Authors
Kyrah M Thumbadoo, Birger V Dieriks, Helen C Murray, Molly E V Swanson, Ji Hun Yoo, Nasim F Mehrabi, Clinton Turner, Michael Dragunow, Richard L M Faull, Maurice A Curtis, Teepu Siddique, Christopher E Shaw, Kathy L Newell, Lyndal Henden, Kelly L Williams, Garth A Nicholson, Emma L Scotter
Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia