Publications

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Jan 17, 2025 - Research

Brain changes in Huntington’s disease occur decades before diagnosis

Subtle changes in the brain happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s disease, finds a new study led by...

Learn more Brain changes in Huntington’s disease occur decades before diagnosis

Jan 08, 2025 - Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s

Phospho-tau accumulation in MAPT knockout mice

Jan 08, 2025 - Research

Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

A new study led by Prof Karen Duff, Dr Naoto Watamura, and Dr Martha Foiani (UK DRI at UCL), with Prof Takaomi Saido (Riken Center...

Learn more Brain damage starts before tau protein clumps in frontotemporal dementia and Alzheimer’s

Nat Commun

Published Jun 08, 2023

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

Authors

Irene Molina-Gonzalez, Rebecca K Holloway, Zoeb Jiwaji, Owen Dando, Sarah A Kent, Katie Emelianova, Amy F Lloyd, Lindsey H Forbes, Ayisha Mahmood, Thomas Skripuletz, Viktoria Gudi, James A Febery, Jeffrey A Johnson, Jill H Fowler, Tanja Kuhlmann, Anna Williams, Siddharthan Chandran, Martin Stangel, Andrew J M Howden, Giles E Hardingham, Veronique E Miron

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration.

bioRxiv

Published Jun 05, 2023

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Authors

K R Bowles, D A Pugh, C Pedicone, L Oja, S A Weitzman, Y Liu, J L Chen, M D Disney, A M Goate

Development of MAPT S305 mutation models exhibiting elevated 4R tau expression, resulting in altered neuronal and astrocytic function.

Toxicon

Published Jun 01, 2023

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Authors

Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiavo

Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

Front Hum Neurosci

Published May 24, 2023

Hyper-parameter tuning and feature extraction for asynchronous action detection from sub-thalamic nucleus local field potentials.

Authors

Thomas Martineau, Shenghong He, Ravi Vaidyanathan, Huiling Tan

Hyper-parameter tuning and feature extraction for asynchronous action detection from sub-thalamic nucleus local field potentials.

Int J Mol Sci

Published May 17, 2023

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

Authors

Yoel Hirsch, Wendy K Chung, Sergey Novoselov, Louis H Weimer, Alexander Rossor, Charles A LeDuc, Amanda J McPartland, Ernesto Cabrera, Josef Ekstein, Sholem Scher, Rick F Nelson, Giampietro Schiavo, Lindsay B Henderson, Kevin T A Booth

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss.

JMIR Res Protoc

Published May 11, 2023

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

Authors

Ting Su, Rafael A Calvo, Melanie Jouaiti, Sarah Daniels, Pippa Kirby, Derk-Jan Dijk, Ciro Della Monica, Ravi Vaidyanathan

Assessing a Sleep Interviewing Chatbot to Improve Subjective and Objective Sleep: Protocol for an Observational Feasibility Study.

JCI Insight

Published May 08, 2023

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Authors

James N Sleigh, David Villarroel-Campos, Sunaina Surana, Tahmina Wickenden, Yao Tong, Rebecca L Simkin, Jose Norberto S Vargas, Elena R Rhymes, Andrew P Tosolini, Steven J West, Qian Zhang, Xiang-Lei Yang, Giampietro Schiavo

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

Semin Cell Dev Biol

Published Apr 30, 2023

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.

Authors

Leire Melgosa-Ecenarro, Nazanin Doostdar, Carola I Radulescu, Johanna S Jackson, Samuel J Barnes

Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease.

PLoS One

Published Apr 28, 2023

What does heritability of Alzheimer's disease represent?

Authors

Emily Baker, Ganna Leonenko, Karl Michael Schmidt, Matthew Hill, Amanda J Myers, Maryam Shoai, Itziar de Rojas, Niccoló Tesi, Henne Holstege, Wiesje M van der Flier, Yolande A L Pijnenburg, Agustin Ruiz, John Hardy, Sven van der Lee, Valentina Escott-Price

What does heritability of Alzheimer's disease represent?

Sci Rep

Published Apr 28, 2023

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain.

Authors

William Lim Kee Chang, Tiffany G Chan, Federica Raguseo, Aishwarya Mishra, Dani Chattenton, Rafael T M de Rosales, Nicholas J Long, Sophie V Morse

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain.

PLoS One

Published Apr 28, 2023

Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.

Authors

Marius Bauza, Marino Krstulovic, Julija Krupic

Unsupervised, frequent and remote: A novel platform for personalised digital phenotyping of long-term memory in humans.

Sci Adv

Published Apr 21, 2023

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.

Authors

Poulomi Banerjee, Arpan R Mehta, Raja S Nirujogi, James Cooper, Owen G James, Jyoti Nanda, James Longden, Karen Burr, Karina McDade, Andrea Salzinger, Evdokia Paza, Judith Newton, David Story, Suvankar Pal, Colin Smith, Dario R Alessi, Bhuvaneish T Selvaraj, Josef Priller, Siddharthan Chandran

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration.

Nature

Published Apr 12, 2023

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.

Authors

Joselyn S Soto, Yasaman Jami-Alahmadi, Jakelyn Chacon, Stefanie L Moye, Blanca Diaz-Castro, James A Wohlschlegel, Baljit S Khakh

Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.

bioRxiv

Published Apr 06, 2023

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human.

Authors

Philip Hasel, Melissa L Cooper, Anne E Marchildon, Uriel A Rufen-Blanchette, Rachel D Kim, Thong C Ma, Un Jung Kang, Moses V Chao, Shane A Liddelow

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in mouse and human.

Cell Metab

Published Apr 04, 2023

Molecular and metabolic heterogeneity of astrocytes and microglia.

Authors

Philip Hasel, William H Aisenberg, F Chris Bennett, Shane A Liddelow

Molecular and metabolic heterogeneity of astrocytes and microglia.

Neuroimage

Published Apr 01, 2023

An infant sleep electroencephalographic marker of thalamocortical connectivity predicts behavioral outcome in late infancy.

Authors

Valeria Jaramillo, Sarah F Schoch, Andjela Markovic, Malcolm Kohler, Reto Huber, Caroline Lustenberger, Salome Kurth

An infant sleep electroencephalographic marker of thalamocortical connectivity predicts behavioral outcome in late infancy.

Science

Published Mar 31, 2023

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.

Authors

Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.

Front Cell Neurosci

Published Mar 22, 2023

Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.

Authors

Rhian Evans, Lewis M Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Michelle Naughton, Marie Dittmer, Mark I Rees, Denise Fitzgerald, B Paul Morgan, James W Neal, Owain W Howell

Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.