Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Sci Adv
Published

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.

Authors
Nicol Birsa, Agnieszka M Ule, Maria Giovanna Garone, Brian Tsang, Francesca Mattedi, P Andrew Chong, Jack Humphrey, Seth Jarvis, Melis Pisiren, Oscar G Wilkins, Micheal L Nosella, Anny Devoy, Cristian Bodo, Rafaela Fernandez de la Fuente, Elizabeth M C Fisher, Alessandro Rosa, Gabriella Viero, Julie D Forman-Kay, Giampietro Schiavo, Pietro Fratta
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.
J Neurol Neurosurg Psychiatry
Published

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

Authors
Maura Malpetti, Luca Passamonti, Peter Simon Jones, Duncan Street, Timothy Rittman, Timothy D Fryer, Young T Hong, Patricia Vàsquez Rodriguez, William Richard Bevan-Jones, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe
Neuroinflammation predicts disease progression in progressive supranuclear palsy.
Eur Stroke J
Published

ESO Guideline on covert cerebral small vessel disease.

Authors
Joanna M Wardlaw, Stephanie Debette, Hanna Jokinen, Frank-Erik De Leeuw, Leonardo Pantoni, Hugues Chabriat, Julie Staals, Fergus Doubal, Salvatore Rudilosso, Sebastian Eppinger, Sabrina Schilling, Raffaele Ornello, Christian Enzinger, Charlotte Cordonnier, Martin Taylor-Rowan, Arne G Lindgren
ESO Guideline on covert cerebral small vessel disease.
Cell Calcium
Published

Multi-scale network imaging in a mouse model of amyloidosis.

Authors
Nazanin Doostdar, Joseph Airey, Carola I Radulescu, Leire Melgosa-Ecenarro, Nawal Zabouri, Pavlina Pavlidi, Maksym Kopanitsa, Takashi Saito, Takaomi Saido, Samuel J Barnes
Multi-scale network imaging in a mouse model of amyloidosis.
J Cell Biol
Published

FUS-dependent liquid-liquid phase separation is important for DNA repair initiation.

Authors
Brunno R Levone, Silvia C Lenzken, Marco Antonaci, Andreas Maiser, Alexander Rapp, Francesca Conte, Stefan Reber, Jonas Mechtersheimer, Antonella E Ronchi, Oliver Mühlemann, Heinrich Leonhardt, M Cristina Cardoso, Marc-David Ruepp, Silvia M L Barabino
FUS-dependent liquid-liquid phase separation is important for DNA repair initiation.
Curr Biol
Published

Astrocytes.

Authors
Philip Hasel, Shane A Liddelow
Astrocytes.
Sci Adv
Published

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.

Authors
Laura Fumagalli, Florence L Young, Steven Boeynaems, Mathias De Decker, Arpan R Mehta, Ann Swijsen, Raheem Fazal, Wenting Guo, Matthieu Moisse, Jimmy Beckers, Lieselot Dedeene, Bhuvaneish T Selvaraj, Tijs Vandoorne, Vanesa Madan, Marka van Blitterswijk, Denitza Raitcheva, Alexander McCampbell, Koen Poesen, Aaron D Gitler, Philipp Koch, Pieter Vanden Berghe, Dietmar Rudolf Thal, Catherine Verfaillie, Siddharthan Chandran, Ludo Van Den Bosch, Simon L Bullock, Philip Van Damme
C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.