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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Nature communications
Published

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Authors
Robert I McGeachan, Soraya Meftah, Lewis W Taylor, James H Catterson, Danilo Negro, Calum Bonthron, Kristján Holt, Jane Tulloch, Jamie L Rose, Francesco Gobbo, Ya Yin Chang, Jamie Elliott, Lauren McLay, Declan King, Imran Liaquat, Tara L Spires-Jones, Sam A Booker, Paul M Brennan, Claire S Durrant
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Scientific reports
Published

Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions

Authors
Huseyin Kilili, Benjamin Padilla-Morales, Atahualpa Castillo-Morales, Jimena Monzón-Sandoval, Karina Díaz-Barba, Paola Cornejo-Paramo, Orsolya Vincze, Mathieu Giraudeau, Stephen J Bush, Zhidan Li, Lu Chen, Evangelos Mourkas, Sergio Ancona, Alejandro Gonzalez-Voyer, Diego Cortez, Humberto Gutierrez, Tamás Székely, Alín P Acuña-Alonzo, Araxi O Urrutia
Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions
European journal of endocrinology
Published

Sex differences between mid-life glycaemic traits and brain volume at age 70: A population-based study

Authors
Nasri Fatih, Alun Hughes, Carole H Sudre, Nish Chaturvedi, Victoria Garfield, Richard J Silverwood, George Ploubidis, Thomas D Parker, Kirsty Lu, David M Cash, Ian B Malone, Andrew Wong, Josephine Barnes, Marcus Richards, Nick C Fox, Jonathan M Schott, Sarah-Naomi James
Sex differences between mid-life glycaemic traits and brain volume at age 70: A population-based study
Cell
Published

Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

Authors
Samuel S Harris, Robert Ellingford, Jana Hartmann, Debanjan Dasgupta, Marten Kehring, Rikesh M Rajani, David Graykowski, Noé Quittot, Dhanush Sivasankaran, Caitlin Commins, Zhanyun Fan, Suraya A Bond, Fred Wolf, David Dupret, Raymond J Dolan, Arthur Konnerth, Andreas Neef, Bradley T Hyman, Marc Aurel Busche
Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Exploring inflammation-related protein expression and its relationship with TSPO PET in Alzheimer's disease

Authors
Ilaria Pola, Nicholas J Ashton, Marco Antônio De Bastiani, Wagner S Brum, Nesrine Rahmouni, Kubra Tan, Luiza Santos Machado, Stijn Servaes, Jenna Stevenson, Cécile Tissot, Joseph Therriault, Tharick A Pascoal, Kaj Blennow, Henrik Zetterberg, Eduardo R Zimmer, Pedro Rosa-Neto, Andréa L Benedet
Exploring inflammation-related protein expression and its relationship with TSPO PET in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

A comparison of p-tau assays for the specificity to detect tau changes in Alzheimer's disease

Authors
Shorena Janelidze, Nicholas J Ashton, Anna Orduña Dolado, Ulrika Nordström, Divya Bali, Karin M E Forsberg, Isil Keskin, Andrea Mastrangelo, Veria Vacchiano, Rocco Liguori, Kaj Blennow, Henrik Zetterberg, Niklas Mattsson-Carlgren, Fernando Gonzalez-Ortiz, Piero Parchi, Peter Munch Andersen, Oskar Hansson
A comparison of p-tau assays for the specificity to detect tau changes in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Resilience in Alzheimer's disease: Impact of operationalization and methodological choices

Authors
Sophie Mutel, Lara Quatrocchi, Daniele Altomare, Christian Chicherio, Max Scheffler, Karl-Olof Lövblad, Kaj Blennow, Nicholas J Ashton, Henrik Zetterberg, Marc Abramowicz, Jean-Louis Blouin, Chen Wang, Carine Wyss-Dominguez, Augusto J Mendes, Valentina Garibotto, Giovanni Frisoni, Federica Ribaldi
Resilience in Alzheimer's disease: Impact of operationalization and methodological choices
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma p-tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease

Authors
Przemysław R Kac, Daniel Alcolea, Laia Montoliu-Gaya, Susana Fernández, Juan Lantero Rodriguez, Lucía Maure, Fernando González-Ortiz, Bessy Benejam, Michael Turton, Isabel Barroeta, Peter Harrison, Laura Videla, Nicholas J Ashton, Alberto Lleó, Henrik Zetterberg, María Carmona-Iragui, Thomas K Karikari, Juan Fortea, Kaj Blennow
Plasma p-tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study

Authors
Daniela Jaime Garcia, Una Clancy, Carmen Arteaga, Maria C Valdés-Hernandez, Francesca M Chappell, Angela C C Jochems, Yajun Cheng, Junfang Zhang, Michael J Thrippleton, Michael S Stringer, Emilie Sleight, Ellen V Backhouse, Stewart Wiseman, Rosalind Brown, Fergus N Doubal, Axel Montagne, Joanna M Wardlaw, MSS3 Study Group
Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study
European journal of nuclear medicine and molecular imaging
Published

Tau profiling across Alzheimer's disease staging reveals vulnerability to disease pathophysiology

Authors
Gleb Bezgin, Tharick A Pascoal, Joseph Therriault, Firoza Z Lussier, Stijn Servaes, Min Su Kang, Mélissa Savard, Cécile Tissot, Jenna Stevenson, Yi-Ting Wang, Julie Ottoy, Nesrine Rahmouni, Jaime Fernandez-Arias, Seyyed Ali Hosseini, Étienne Aumont, Brandon Hall, Nina Margherita Poltronetti, Vanessa Pallen, Andréa Lessa Benedet, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Thomas K Karikari, Tatsuhiro Terada, Mira Chamoun, Sulantha Mathotaarachchi, Arthur Cassa Macedo, Alyssa Stevenson, Peter Kunach, Gassan Massarweh, Paolo Vitali, Jean-Paul Soucy, Yasser Iturria-Medina, Serge Gauthier, Pedro Rosa-Neto
Tau profiling across Alzheimer's disease staging reveals vulnerability to disease pathophysiology