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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Brain : a journal of neurology
Published

Misdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease

Authors
Sarah McGlasson, Katy Reid, Anna Klingseisen, Bastien Rioux, Samuel Chauvin, Cathrine A Miner, Joe Holley, Deborah Forbes, Bethany Geary, Jeffrey Kimber, Katrina Wood, Candice Roufosse, Colin Smith, David Kavanagh, Jonathan Miner, David P J Hunt
Misdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease
bioRxiv : the preprint server for biology
Published

Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study

Authors
G Brezzo, K A Zera, D Straus, J E Goertz, S H Loppi, R Crumpacker, J B Frye, D A Becktel, M I Cuartero, A García Culebras, C Dames, D Berchtold, J H Fowler, A Meisel, J Anrather, M A Moro, S M Allan, K P Doyle, M S Buckwalter, B W McColl
Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study
The journal of prevention of Alzheimer's disease
Published

Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer's disease

Authors
Sarah Abbas, Pamela C L Ferreira, Bruna Bellaver, Guilherme Povala, Francieli Rohden, Cristiano Schaffer Aguzzoli, Hussein Zalzale, João Pedro Ferrari-Souza, Douglas T Leffa, Firoza Z Lussier, Carolina Soares, Guilherme Bauer-Negrini, Markley Silva Oliveira-Junior, Matheus Scarpatto Rodrigues, Pampa Saha, Emma Ruppert, Marina Scop Medeiros, Cécile Tissot, Joseph Therriault, Nesrine Rahmouni, Stijn Servaes, Andrea L Benedet, Nicholas J Ashton, Dana L Tudorascu, Serge Gauthier, Helmet Karim, Chang Hyung Hong, Hyun Woong Roh, Eduardo R Zimmer, Thomas K Karikari, Henrik Zetterberg, Kaj Blennow, Anum Saeed, Sang Joon Son, Pedro Rosa-Neto, Tharick Pascoal, for Alzheimer’s Disease Neuroimaging Initiative
Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

LC-MS/MS proteomics identifies plasma proteins related to cognition over 9-year follow-up

Authors
Hailey A Adegboye, Khiry L Patterson, Julia Libby, Yunyi Sun, Panpan Zhang, Dandan Liu, W Hudson Robb, Amalia J Peterson, Keith R Cole, Albert B Arul, Nekesa C Oliver, Marsalas D Whitaker, Kimberly R Pechman, Logan Dumitrescu, Corey J Bolton, Kaj Blennow, Henrik Zetterberg, Timothy J Hohman, Renã A S Robinson, Angela L Jefferson
LC-MS/MS proteomics identifies plasma proteins related to cognition over 9-year follow-up
Nature neuroscience
Published

Author Correction: Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus

Authors
Kyoko Tossell, Xiao Yu, Panagiotis Giannos, Berta Anuncibay Soto, Mathieu Nollet, Raquel Yustos, Giulia Miracca, Mikal Vicente, Andawei Miao, Bryan Hsieh, Ying Ma, Alexei L Vyssotski, Tim Constandinou, Nicholas P Franks, William Wisden
Author Correction: Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus
Movement disorders : official journal of the Movement Disorder Society
Published

Identification of GGC Repeat Expansions in ZFHX3 among Chilean Movement Disorder Patients

Authors
Paula Saffie-Awad, Abraham Moller, Kensuke Daida, Pilar Alvarez Jerez, Zhongbo Chen, Zachary B Anderson, Mariam Isayan, Kimberly Paquette, Sophia B Gibson, Madison Fulcher, Abigail Miano-Burkhardt, Laksh Malik, Breeana Baker, Paige Jarreau, Henry Houlden, Mina Ryten, Bida Gu, Mark J P Chaisson, Danny E Miller, Pedro Chaná-Cuevas, Cornelis Blauwendraat, Andrew B Singleton, Kimberley J Billingsley
Identification of GGC Repeat Expansions in ZFHX3 among Chilean Movement Disorder Patients
Scientific reports
Published

Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer's disease cohort

Authors
Elizabeth M Planalp, Rebecca E Langhough, Erin M Jonaitis, Carol A Van Hulle, Rachael E Wilson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Ozioma C Okonkwo, Barbara B Bendlin, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C Johnson
Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer's disease cohort
Science advances
Published

Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration

Authors
Michael R Duggan, Shuojia Yang, Gabriela T Gomez, Yuhan Cui, Ana W Capuano, Jingsha Chen, Zhijian Yang, Junhao Wen, Guray Erus, Shannon M Drouin, David Zweibaum, Qu Tian, Julián Candia, Murat Bilgel, Alexandria Lewis, Abhay Moghekar, Nicholas J Ashton, Przemysław R Kac, Thomas K Karikari, Kaj Blennow, Henrik Zetterberg, Brion S Maher, Adam P Spira, Logan Dumitrescu, Timothy J Hohman, Rebecca F Gottesman, Christos Davatzikos, David A Bennett, Josef Coresh, Luigi Ferrucci, Susan M Resnick, Robert Yolken, Keenan A Walker
Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference

Authors
Bess Frost, James B Rowe, Rufus O Akinyemi, Jose F Abisambra, Nicholas J Ashton, Matthias Brendel, Luc Buée, David Butler, Maria C Carrillo, Peter Chung, Claire D Clelland, Sarah L DeVos, Kristophe Diaz, Rebecca M Edelmayer, Fanny M Elahi, Ratnavalli Ellajosyula, Colin Ewen, Igor Camargo Fontana, Marie-Christine Galas, Oskar Hansson, Günter Höglinger, Kanta Horie, Agustín Ibanez, Linde Jacobs, Mahmoud B Maina, Maura Malpetti, Eric McDade, Will McEwan, Laia Montoliu-Gaya, Catherine J Mummery, Miranda E Orr, Jonathan D Rohrer, Amy Rommel, Carlos Sastre, Tara L Spires-Jones, Boon Lead Tee, Tim J Viney, Jamie M Walker, Susanne Wegmann, Kristin Wildsmith, Ravi Yadav, Simin Mahinrad, Claire Sexton
Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference