Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Acta neuropathologica
Published

Confirmation of p-tau Ser356's association with Alzheimer's disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: "Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer's pathology"

Authors
Lewis W Taylor, Elizabeth M Simzer, Lauren F P Young, Kristján Holt, Tara L Spires-Jones, Claire S Durrant
Confirmation of p-tau Ser356's association with Alzheimer's disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: "Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer's pathology"
Scientific reports
Published

Integrative analysis of AT classification, plasma biomarkers, and cognitive trajectories across diverse dementia syndromes

Authors
Jihwan Yun, Min Young Chun, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Daeun Shin, Soyeon Yoon, Heejin Yoo, Jun Pyo Kim, Hongki Ham, Yuna Gu, Hee Jin Kim, Seung Hwan Moon, Hanna Cho, Jae Yong Choi, Byung Hyun Byun, Su Yeon Park, Jeong Ho Ha, Duk L Na, Sang Won Seo, Hyemin Jang
Integrative analysis of AT classification, plasma biomarkers, and cognitive trajectories across diverse dementia syndromes
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Development of language composites for enhanced sensitivity to multiple plasma biomarkers

Authors
Deling He, Rebecca E Langhough, Carol Van Hulle, Kristin Basche, Erin Jonaitis, Rachael Wilson, Bruce Hermann, Henrik Zetterberg, Sterling Johnson, Kimberly D Mueller
Development of language composites for enhanced sensitivity to multiple plasma biomarkers
Nature communications
Published

Publisher Correction: A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics

Authors
Yuki Kamijo, Philipp Mächler, Natalie Ness, Cong Quang Vu, Tsukasa Kusakizako, Jamsad Mannuthodikayil, Zaneta Ku, Marc Boisvert, Ekaterina Grebenik, Ikumi Miyazaki, Rina Hashizume, Haruaki Sato, Rui Liu, Yukiko Hori, Taisuke Tomita, Tetsuro Katayama, Akihiro Furube, Gabriela Caraveo, Marie-Eve Paquet, Mikhail Drobizhev, Osamu Nureki, Satoshi Arai, Marco Brancaccio, Robert E Campbell, David Kleinfeld, Yusuke Nasu
Publisher Correction: A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics
Nature communications
Published

Computational whole-body-exposome models for global precision brain health

Authors
Agustín Ibáñez, Claudia Duran-Aniotz, Joaquín Migeot, Sandra Báez, Sol Fittipaldi, Carlos Coronel-Oliveros, Harris A Eyre, Chinedu Udeh-Momoh, Henrik Zetterberg, Suvarna Alladi, Carmen Sandi, Ian H Robertson, Sanne Franzen, Temitope Farombi, Janitza L Montalvo Ortiz, Sudha Seshadri, Felipe Court, Pedro Valdes-Sosa, Jiayuan Xu, Chunshui Yu, Lea Grinberg, Brian Lawlor, Perminder S Sachdev, Kristine Yaffe, Vladimir Hachinski, Karl Friston, Enzo Tagliazucchi, Hernando Santamaría-García
Computational whole-body-exposome models for global precision brain health
Journal of Alzheimer's disease : JAD
Published

Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer's disease

Authors
Prita R Asih, Cameron W Morris, Hong Wang, Steve Pedrini, Kathryn Goozee, Simon M Laws, Pratishtha Chatterjee, Kevin Taddei, Hamid R Sohrabi, Stephanie R Rainey-Smith, Chai K Lim, Gilles J Guillemin, Thomas K Karikari, Colin L Masters, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Ralph N Martins
Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer's disease
EJNMMI physics
Published

Performance evaluation of the nanoScan<sup>®</sup> P123S total-body PET

Authors
Dániel Réti, Carlos-Alcaide Corral, Islay Cranston, Victoria J M Reid, Kerry M O'Rourke, Timaeus E F Morgan, Axel Montagne, Maurits A Jansen, Valeria K Burianova, Andrew Sutherland, Péter Major, Kálmán Nagy, Gergő Bagaméry, Adriana A S Tavares
Performance evaluation of the nanoScan<sup>®</sup> P123S total-body PET
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study

Authors
Gaia Brezzo, Kristy A Zera, Dana E Straus, Jennifer E Goertz, Sanna H Loppi, Rachel R Crumpacker, Jennifer B Frye, Danielle A Becktel, Maria Isabel Cuartero, Alicia García Culebras, Claudia Dames, Daniel Berchtold, Jill H Fowler, Andreas Meisel, Josef Anrather, Maria Angeles Moro, Stuart M Allan, Kristian P Doyle, Marion S Buckwalter, Barry W McColl
Assessing post-stroke cognition in pre-clinical models: Lessons and recommendations from a multi-center study
Scientific reports
Published

Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study

Authors
Felix Klawitter, Johanna Hackenberg, Lena Danckert, Astrid Bertsche, Axel Petzold, Heidi A B Smith, Eugene Wesley Ely, Christian Spang, Rika Bajorat, Dagmar-Christiane Fischer, Gerd Klinkmann, Anne Körmann-Günther, Robert Fleischmann, Amanda Heslegrave, Henrik Zetterberg, Hessel Peters-Sengers, Johannes Ehler, Critical Care Consultant
Impact of meningoencephalitis and sepsis on delirium and subsequent neurological impairment in pediatric patients: a prospective proof-of-concept biomarker and EEG study
Pituitary
Published

Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas

Authors
Martin Thorsson, P Trimpou, M Asztély, T Hallén, V Hantelius, K Blennow, H Zetterberg, G Johannsson, J Oras, T Skoglund
Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas
BMJ open
Published

Digital App for Speech and Health Monitoring Study (DASH): protocol for a prospective longitudinal case-control observational study for developing speech datasets in neurodegenerative disorders and dementia

Authors
Johnny Tam, Christine Weaver, Amarachi Ihenacho, Judith Newton, Bruce Virgo, Steven Barrett, Jonathan Neale, David Perry, Alice Smith, Siddharthan Chandran, Oliver Watts, Suvankar Pal, DASH Consortium
Digital App for Speech and Health Monitoring Study (DASH): protocol for a prospective longitudinal case-control observational study for developing speech datasets in neurodegenerative disorders and dementia
Alzheimer's research & therapy
Published

Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology

Authors
Larissa Fischer, Dana Parker, Samira Maboudian, Corrina Fonseca, Claudia Tato-Fernández, Lucie Annen, Prithvi Arunachalam, Julia R Bacci, Michelle Barboure, Serena Capelli, Stamatia Karagianni, Lyduine E Collij, Paul Edison, Nick C Fox, Nicolai Franzmeier, Michel J Grothe, William J Jagust, Anne Maass, Maura Malpetti, Ross W Paterson, Aitana Sogorb-Esteve, Michael Schöll
Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology
Brain : a journal of neurology
Published

Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration

Authors
Julie F H De Houwer, Elise G Dopper, Renee van Buuren, Marijke Stokkel, Liset de Boer, Tine Swartenbroekx, Pam A Boesjes, Ana Rajicic, Aitana Sogorb-Esteve, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, John C van Swieten, Lize C Jiskoot, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Benedetta Nacmias, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Simon Ducharme, Chris R Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Henrik Zetterberg, Jonathan D Rohrer, Betty M Tijms, Yolande A L Pijnenburg, Charlotte Teunissen, Harro Seelaar
Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration
Brain and neuroscience advances
Published

The UK National Mouse Genetics Network: Translating genetic findings using preclinical mouse models to better understand neurodevelopmental, neuropsychiatric and neurodegenerative disorders

Authors
Sevda T Boyanova, Nicholas E Clifton, Karolina Dec, Michal M Milczarek, MURIDAE Cluster, Anthony R Isles
The UK National Mouse Genetics Network: Translating genetic findings using preclinical mouse models to better understand neurodevelopmental, neuropsychiatric and neurodegenerative disorders
medRxiv : the preprint server for health sciences
Published

Genetic drivers of progression in Alzheimer's disease are distinct from disease risk

Authors
Celeste E Cohen, Shane Fernandez, Umran Yaman, Ahmad R Ehyaei, Tenielle Porter, Eleanor O'Brien, Australian Imaging Biomarkers and Lifestyle Study, Alzheimer’s Disease Neuroimaging Initiative, Paul Maruff, John A Hardy, Simon M Laws, Dervis Salih, Maryam Shoai
Genetic drivers of progression in Alzheimer's disease are distinct from disease risk
bioRxiv : the preprint server for biology
Published

<em>APOE</em> E4 Alzheimer's Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex

Authors
Louise A Huuki-Myers, Heena R Divecha, Svitlana V Bach, Madeline R Valentine, Nicholas J Eagles, Bernard Mulvey, Rahul A Bharadwaj, Ruth Zhang, James R Evans, Melissa Grant-Peters, Ryan A Miller, Joel E Kleinman, Shizhong Han, Thomas M Hyde, Stephanie C Page, Daniel R Weinberger, Keri Martinowich, Mina Ryten, Kristen R Maynard, Leonardo Collado-Torres
<em>APOE</em> E4 Alzheimer's Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex