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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

The Lancet. Neurology
Published

Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study

Authors
Yihua Ma, Carly M Farris, Sandrina Weber, Sebastian Schade, Hieu Nguyen, Alexandra Pérez-Soriano, Darly M Giraldo, Manel Fernández, Marta Soto, Ana Cámara, Celia Painous, Esteban Muñoz, Francesc Valldeoriola, Maria J Martí, Jordi Clarimon, Pekka Kallunki, Thong Chi Ma, Roy N Alcalay, Bárbara Fernandez Gomes, Kaj Blennow, Henrik Zetterberg, Julius Constantinescu, David Mengel, Vaibhavi Kadam, Piero Parchi, Kathrin Brockmann, Thomas F Tropea, Andrew Siderowf, Matthis Synofzik, Un Jung Kang, Yaroslau Compta, Per Svenningsson, Brit Mollenhauer, Luis Concha-Marambio
Sensitivity and specificity of a seed amplification assay for diagnosis of multiple system atrophy: a multicentre cohort study
Nature neuroscience
Published

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease

Authors
Stephanie L Fowler, Tiana S Behr, Emir Turkes, Darragh P O'Brien, Paula Maglio Cauhy, Isadora Rawlinson, Marisa Edmonds, Martha S Foiani, Ari Schaler, Gerard Crowley, Sumi Bez, Elena Ficulle, Eliona Tsefou, Roman Fischer, Beth Geary, Pallavi Gaur, Chelsea Miller, Pasquale D'Acunzo, Efrat Levy, Karen E Duff, Benjamin Ryskeldi-Falcon
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease

Authors
Ramiro Eduardo Rea Reyes, Karly A Cody, Rachael E Wilson, Henrik Zetterberg, Nathaniel A Chin, Erin M Jonaitis, Melissa Bahr, Olivia Mandel, Madilynn Wintlend, Barbara B Bendlin, Ozioma C Okonkwo, Lindsay R Clark, Matt Zammit, Sanjay Asthana, Bradley T Christian, Tobey J Betthauser, Laura Eisenmenger, Rebecca E Langhough, Sterling C Johnson
Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases

Authors
William Z Lin, Di Yu, Lisa Y Xiong, Julia Zebarth, Ruoding Wang, Corinne E Fischer, Tarek K Rajji, David F Tang-Wai, Carmela Tartaglia, Gustavo Saposnik, Richard H Swartz, David A Grimes, Anthony E Lang, Robert A Hegele, Sali Farhan, Joel Ramirez, Sean Symons, Maged Goubran, Malcolm A Binns, Wendy Lou, Roger A Dixon, Joseph B Orange, Angela C Roberts, Angela K Troyer, Henrik Zetterberg, Nathan Herrmann, Jennifer S Rabin, Bradley J MacIntosh, Mario Masellis, Krista L Lanctôt, Sandra E Black, Walter Swardfager, ONDRI Investigators
Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Published

Associations of life-course cardiovascular risk factors with late-life cerebral haemodynamics

Authors
Mathijs Bj Dijsselhof, Jorina Holtrop, Sarah-Naomi James, Carole H Sudre, Kirsty Lu, Luigi Lorenzini, Lyduine E Collij, Catherine J Scott, Emily N Manning, David L Thomas, Marcus Richards, Alun D Hughes, David M Cash, Frederik Barkhof, Jonathan M Schott, Jan Petr, Henk Jmm Mutsaerts
Associations of life-course cardiovascular risk factors with late-life cerebral haemodynamics
Annals of neurology
Published

Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease

Authors
Michael S Stringer, Gordon W Blair, Anna Kopczak, Danielle Kerkhofs, Michael J Thrippleton, Francesca M Chappell, Susana Muñoz Maniega, Rosalind Brown, Kirsten Shuler, Iona Hamilton, Daniela Jaime Garcia, Fergus N Doubal, Una Clancy, Eleni Sakka, Tetiana Poliakova, Esther Janssen, Marco Duering, Michael Ingrisch, Julie Staals, Walter H Backes, Robert van Oostenbrugge, Geert Jan Biessels, Martin Dichgans, Joanna M Wardlaw, SVDs@target consortium
Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease
Annals of neurology
Published

Elevated Cerebrospinal Fluid Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers

Authors
Elizabeth R Dellar, Iolanda Vendrell, Benazir Amein, David G Lester, Evan C Edmond, Katie Yoganathan, Thanuja Dharmadasa, Aitana Sogorb-Esteve, Roman Fischer, Kevin Talbot, Jonathan D Rohrer, Martin R Turner, Alexander G Thompson
Elevated Cerebrospinal Fluid Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers
Neurology
Published

Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke: Results From the ENCHANTED Study

Authors
Yanan Wang, Toshiki Maeda, Shoujiang You, Chen Chen, Leibo Liu, Zien Zhou, Thompson G Robinson, Richard Iain Lindley, Candice Delcourt, Grant Mair, Joanna M Wardlaw, John Philip Chalmers, Hisatomi Arima, Yining Huang, Jong S Kim, Pablo M Lavados, Tsong-Hai Lee, Christopher Levi, Mark W Parsons, Sheila Co Martins, Jeyaraj Durai Pandian, Octavio M Pontes-Neto, Vijay K Sharma, Thang Huy Nguyen, Jiguang Wang, Simiao Wu, Ming Liu, Craig S Anderson, Xiaoying Chen, ENCHANTED Investigators
Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke: Results From the ENCHANTED Study
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Published

Dorsal metatarsal artery perforator flaps (DMTAPF) applied for paediatric foot reconstruction: A review of the aetiology of primary injury, surgical technique applied, and long-term outcome for the child

Authors
Yvette Godwin, Mohammed Wadi, Louai Harb, Lise Rosenlund Skov
Dorsal metatarsal artery perforator flaps (DMTAPF) applied for paediatric foot reconstruction: A review of the aetiology of primary injury, surgical technique applied, and long-term outcome for the child
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors

Authors
Eun Hye Lee, Sung Hoon Kang, Daeun Shin, Young Ju Kim, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J Ashton, Bo Kyoung Cheon, Heejin Yoo, Hongki Ham, Jihwan Yun, Jun Pyo Kim, Hee Jin Kim, Duk L Na, Hyemin Jang, Sang Won Seo, K‐ROAD study group
Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and monitoring

Authors
Melissa E Petersen, Lisi Flores-Aguilar, Elizabeth Head, Laia Montoliu-Gaya, Andre Strydom, Sarah E Pape, Juan Fortea, Nicholas J Ashton, Chinedu Udeh-Momoh, Sid E O'Bryant, Dwight German, Florin Despa, Mark Mapstone, Henrik Zetterberg
Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and monitoring