Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Neuropsychology
Published

Robust longitudinal neuropsychological norms in Spanish individuals with nonpathological Alzheimer's disease biomarkers

Authors
David López-Martos, Anna Brugulat-Serrat, Marc Suárez-Calvet, Marta Milà-Alomà, Carolina Minguillon, Juan Domingo Gispert, Henrik Zetterberg, Kaj Blennow, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides, ALFA Study
Robust longitudinal neuropsychological norms in Spanish individuals with nonpathological Alzheimer's disease biomarkers
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay

Authors
Nicholas J Ashton, Andrea L Benedet, Guglielmo Di Molfetta, Ilaria Pola, Federica Anastasi, Aida Fernández-Lebrero, Albert Puig-Pijoan, Ashvini Keshavan, Jonathan Schott, Kubra Tan, Joel Simrén, Bárbara Fernandes Gomes, Laia Montoliu-Gaya, Richard Isaacson, Matilde Bongianni, Chiara Tolassi, Valentina Cantoni, Antonella Alberici, Alessandro Padovani, Gianluigi Zanusso, Andrea Pilotto, Barbara Borroni, Marc Suárez-Calvet, Kaj Blennow, Henrik Zetterberg
Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay
Frontiers in neuroscience
Published

TREM2 supports neuronal protection and microglial reactivity without an effect on misfolded protein deposition in chronic neurodegenerative prion disease

Authors
Sarah M Carpanini, Barry M Bradford, Alessio Alfieri, Pedro Piccardo, Jimena Monzón-Sandoval, Deborah Brown, Aileen Boyle, Aleksandra Pokrovskaya, Neil A Mabbott, Jean Manson, Barry W McColl
TREM2 supports neuronal protection and microglial reactivity without an effect on misfolded protein deposition in chronic neurodegenerative prion disease
Traffic (Copenhagen, Denmark)
Published

A Sensitive and Versatile Cell-Based Assay Combines Luminescence and Trapping Approaches to Monitor Unconventional Protein Secretion

Authors
Morgane Denus, Aurore Filaquier, William Fargues, Eloïse Néel, Sarah E Stewart, Maëlle Colladant, Thomas Curel, Alexandre Mezghrani, Philippe Marin, Sylvie Claeysen, David C Rubinsztein, Marie-Laure Parmentier, Julien Villeneuve
A Sensitive and Versatile Cell-Based Assay Combines Luminescence and Trapping Approaches to Monitor Unconventional Protein Secretion
medRxiv : the preprint server for health sciences
Published

<em>APOE</em> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease

Authors
Jesper Qvist Thomassen, Leonard Hampton, Brittany Ulms, Benjamin Grenier-Boley, Sami Heikkinen, Pablo Garcia, Atahualapa Castillo-Morales, Masataka Kikuchi, Jungsoo Gim, Han Cao, Fahri Küçükali, Najaf Amin, Dabin Yoon, Itziar de Rojas, Pilar Alvarez Jerez, Victoria Alvarez, Beatrice Arosio, Celine Bellenguez, Sverre Bergh, Kimberly Billingsley, Cornelis Blauwendraat, Merce Boada, Barbara Borroni, Paola Bossù, María J Bullido, Antonio Daniele, Ángel Carracedo, Alexandre de Mendonça, Mark Cookson, Jürgen Deckert, Martin Dichgans, Srdjan Djurovic, Oriol Dols-Icardo, Carole Dufouil, Emrah Düzel, Valentina Escott-Price, Tormod Fladby, Laura Fratiglioni, Amy K Y Fu, Daniela Galimberti, Jose Maria García-Alberca, Vilmantas Giedraitis, Guillermo Garcia-Ribas, Caroline Graff, Timo Grimmer, Edna Grünblatt, OIivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Hemibach, Jakub Hort, Frank Jessen, Kendall Jensen, Caroline Jonson, Yoontae Kim, Nicole Kuznetsov, Ville Leinonen, Anssi Lipponen, Jiao Luo, Mary Makarious, Henna Martiskainen, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Pablo Mir, Akinori Miyashita, Susanne Moebus, Kin Y Mok, Laura Molina Porcel, Fermin Moreno, Benedetta Nacmias, Lucilla Parnetti, Pau Pastor, Jordi Pérez-Tur, Oliver Peters, Yolande A L Pijnenburg, Gerard Piñol-Ripoll, Julius Popp, Innocenzo Rainero, Luis M Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Arvid Rongve, Giacomina Rossi, Jose Luis Royo, Dan Rujescu, Ingvild Saltvedt, María Eugenia Sáez, Raquel Sánchez-Valle, Florentino Sanchez-Garcia, Nicolai Sandau, Nikolaos Scarmeas, Katja Scheffler, Norbert Scherbaum, Anja Schneider, Geir Selbæk, Davide Seripa, Vincenzo Solfrizzi, Marco Spallazzi, Alessio Squassina, Eystein Stordal, Niccoló Tesi, Lucio Tremolizzo, Kumar P Tripathi, Wiesje M van der Flier, Julie Williams, Jens Wiltfang, Dag Aarsland, Andrew B Singleton, Philippe Amouyel, Stéphanie Debette, Gael Nicolas, Sven van der Lee, Henne Holstege, Maria Victoria Fernandez, Patrick Gavin Kehoe, Kristel Sleegers, Martin Ingelsson, Roberta Ghidoni, Ole A Andreassen, Peter A Holmans, Pascual Sánchez-Juan, Rebecca Sims, Nancy Y Ip, Kun Ho Lee, Takeshi Ikeuchi, Alfredo Ramirez, Agustin Ruiz, Mikko Hiltunen, Jean-Charles Lambert, Cornelia van Duijn, Mike Nalls, Ruth Frikke-Schmidt
<em>APOE</em> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease
JAMA neurology
Published

Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease

Authors
Alexa Pichet Binette, Ruben Smith, Gemma Salvadó, Pontus Tideman, Isabelle Glans, Danielle van Westen, Colin Groot, Rik Ossenkoppele, Erik Stomrud, Piero Parchi, Henrik Zetterberg, Kaj Blennow, Niklas Mattsson-Carlgren, Shorena Janelidze, Sebastian Palmqvist, Oskar Hansson, Alzheimer’s Disease Neuroimaging Initiative
Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease
Nature communications
Published

Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS

Authors
Christoph Schweingruber, Jik Nijssen, Jonas Mechtersheimer, Stefan Reber, Mélanie Lebœuf, Niamh L O'Brien, Irene Mei, Erin Hedges, Michaela Keuper, Julio Aguila Benitez, Vlad Radoi, Martin Jastroch, Marc-David Ruepp, Eva Hedlund
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS
Acta neuropathologica
Published

Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease

Authors
Clíona Farrell, Yazead Buhidma, Paige Mumford, Wendy E Heywood, Jenny Hällqvist, Lisi Flores-Aguilar, Elizabeth J Andrews, Negin Rahimzadah, Orjona Stella Taso, Eric Doran, Vivek Swarup, Elizabeth Head, Tammaryn Lashley, Kevin Mills, Christina E Toomey, Frances K Wiseman
Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Disclosure of plasma p-tau217 measure improves diagnostic confidence in patients with Alzheimer's disease versus syndromes associated with frontotemporal lobar degeneration

Authors
Valentina Cantoni, Maria Sofia Cotelli, Matteo Rota, Antonella Alberici, Ilenia Libri, Hanna Huber, Kübra Tan, Roberta Ghidoni, Sonia Bellini, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Barbara Borroni
Disclosure of plasma p-tau217 measure improves diagnostic confidence in patients with Alzheimer's disease versus syndromes associated with frontotemporal lobar degeneration
Neurology
Published

Associations Between Changes in Levels of Phosphorylated Tau and Severity of Cognitive Impairment in Early Alzheimer Disease

Authors
Fernando Gonzalez-Ortiz, Bjørn-Eivind Kirsebom, Yara Yakoub, Julia K Gundersen, Lene Pålhaugen, Knut Waterloo, Per Selnes, Jonas Alexander Jarholm, Berglind Gísladóttir, Arvid Rongve, Ragnhild Eide Skogseth, Geir Bråthen, Dag Aarsland, Michael Turton, Peter Harrison, Henrik Zetterberg, Sylvia Villeneuve, Tormod Fladby, Kaj Blennow
Associations Between Changes in Levels of Phosphorylated Tau and Severity of Cognitive Impairment in Early Alzheimer Disease
Nature neuroscience
Published

Activity-driven myelin sheath growth is mediated by mGluR5

Authors
Philipp N Braaker, Xuelong Mi, Daniel Soong, Jenea M Bin, Katy Marshall-Phelps, Stephen Bradley, Silvia Benito-Kwiecinski, Julia Meng, Donia Arafa, Claire Richmond, Marcus Keatinge, Guoqiang Yu, Rafael G Almeida, David A Lyons
Activity-driven myelin sheath growth is mediated by mGluR5