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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies

Authors
Lucy L Gibson, Maria C Gonzalez, Nicholas J Ashton, Diego Tovar-Rios, Frédéric Blanc, Andrea Pilotto, Afina Lemstra, Claire Paquet, Clive Ballard, Henrik Zetterberg, Dag Aarsland, European–Dementia With Lewy Bodies (E‐DLB) Consortium
Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies
Brain communications
Published

The CSF p-tau/β-amyloid 42 ratio correlates with brain structure and fibrillary β-amyloid deposition in cognitively unimpaired individuals at the earliest stages of pre-clinical Alzheimer's disease

Authors
Raffaele Cacciaglia, Mahnaz Shekari, Gemma Salvadó, Marta Milà-Alomà, Carles Falcon, Gonzalo Sánchez-Benavides, Carolina Minguillón, Karine Fauria, Oriol Grau-Rivera, José Luis Molinuevo, Kaj Blennow, Henrik Zetterberg, Frances-Catherine Quevenco, Marc Suárez-Calvet, Juan Domingo Gispert, ALFA Study
The CSF p-tau/β-amyloid 42 ratio correlates with brain structure and fibrillary β-amyloid deposition in cognitively unimpaired individuals at the earliest stages of pre-clinical Alzheimer's disease
Alzheimer's research & therapy
Published

Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer's disease

Authors
Georgette Argiris, Muge Akinci, Cleofé Peña-Gómez, Eleni Palpatzis, Marina Garcia-Prat, Mahnaz Shekari, Kaj Blennow, Henrik Zetterberg, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nicholas J Ashton, Thomas K Karikari, Ann Brinkmalm-Westman, Juan Lantero-Rodriguez, Karine Fauria, Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Marc Suárez-Calvet, Eider M Arenaza-Urquijo, For The Alfa Study
Data-driven CSF biomarker profiling: imaging and clinical outcomes in a cohort at risk of Alzheimer's disease
Nature neuroscience
Published

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

Authors
Naoto Watamura, Martha S Foiani, Sumi Bez, Mathieu Bourdenx, Alessia Santambrogio, Claire Frodsham, Elena Camporesi, Gunnar Brinkmalm, Henrik Zetterberg, Saisha Patel, Naoko Kamano, Mika Takahashi, Javier Rueda-Carrasco, Loukia Katsouri, Stephanie Fowler, Emir Turkes, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Afm Saiful Islam, Seico Benner, Toshihiro Endo, Katsuji Kobayashi, Chiho Ishida, Michele Vendruscolo, Masahito Yamada, Karen E Duff, Takaomi C Saido
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition

Authors
Corey J Bolton, Marilyn Steinbach, Omair A Khan, Dandan Liu, Julia O'Malley, Logan Dumitrescu, Amalia Peterson, Angela L Jefferson, Timothy J Hohman, Henrik Zetterberg, Katherine A Gifford, Alzheimer's Disease Neuroimaging Initiative
Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition
Neurology
Published

Comparison of Plasma p-tau217 and [<sup>18</sup>F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical Dementia

Authors
Kely Monica Quispialaya, Joseph Therriault, Antonio Aliaga, Andrea L Benedet, Nicholas J Ashton, Thomas Karikari, Arthur Cassa Macedo, Nesrine Rahmouni, Cécile Tissot, Jaime Fernandez Arias, Yi-Ting Tina Wang, Lydia Trudel, Seyyed Ali Hosseini, Takashi Matsudaira, Tevy Chan, Tharick Pascoal, Brian Gilfix, Paolo Vitali, Eduardo R Zimmer, Karine Provost, Jean-Paul Soucy, Serge Gauthier, Henrik Zetterberg, Bertrand J Jean-Claude, Kaj Blennow, Pedro Rosa-Neto
Comparison of Plasma p-tau217 and [<sup>18</sup>F]FDG-PET for Identifying Alzheimer Disease in People With Early-Onset or Atypical Dementia
Brain : a journal of neurology
Published

C21ORF2 mutations point towards primary cilia dysfunction in amyotrophic lateral sclerosis

Authors
Mathias De Decker, Pavol Zelina, Thomas G Moens, Jimmy Beckers, Matilde Contardo, Katarina Stoklund Dittlau, Evelien Van Schoor, Alicja Ronisz, Kristel Eggermont, Matthieu Moisse, Siddharthan Chandran, Jan H Veldink, Dietmar Rudolf Thal, Ludo Van Den Bosch, R Jeroen Pasterkamp, Philip Van Damme
C21ORF2 mutations point towards primary cilia dysfunction in amyotrophic lateral sclerosis
Stem cells (Dayton, Ohio)
Published

Changes in iPSC-Astrocyte morphology reflect Alzheimer's disease patient clinical markers

Authors
Helen A Rowland, Georgina Miller, Qiang Liu, Shuhan Li, Nicola R Sharp, Bryan Ng, Tina Wei, Kanisa Arunasalam, Ivan Koychev, Anne Hedegaard, Elena M Ribe, Dennis Chan, Tharani Chessell, Ece Kocagoncu, Jennifer Lawson, Paresh Malhotra, Basil H Ridha, James B Rowe, Alan J Thomas, Giovanna Zamboni, Henrik Zetterberg, M Zameel Cader, Richard Wade-Martins, Simon Lovestone, Alejo Nevado-Holgado, Andrey Kormilitzin, Noel J Buckley
Changes in iPSC-Astrocyte morphology reflect Alzheimer's disease patient clinical markers
EBioMedicine
Published

Disentangling relationships between Alzheimer's disease plasma biomarkers and established biomarkers in patients of tertiary memory clinics

Authors
Marina Bluma, Konstantinos Chiotis, Marco Bucci, Irina Savitcheva, Anna Matton, Miia Kivipelto, Andreas Jeromin, Giovanni De Santis, Guglielmo Di Molfetta, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Agneta Nordberg
Disentangling relationships between Alzheimer's disease plasma biomarkers and established biomarkers in patients of tertiary memory clinics
Journal of neurology, neurosurgery, and psychiatry
Published

How well do plasma Alzheimer's disease biomarkers reflect the CSF amyloid status?

Authors
Jemma Hazan, Emily Abel, Miguel Rosa Grilo, Deborah Alawode, Ines Laranjinha, Amanda J Heslegrave, Kathy Y Liu, Jonathan M Schott, Robert Howard, Henrik Zetterberg, Nick C Fox
How well do plasma Alzheimer's disease biomarkers reflect the CSF amyloid status?
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference

Authors
Courtney M Kloske, Simin Mahinrad, Christopher J Barnum, Andre F Batista, Elizabeth M Bradshaw, Brittany Butts, Maria C Carrillo, Paramita Chakrabarty, Xiaoying Chen, Suzanne Craft, Sandro Da Mesquita, Luke C Dabin, Davangere Devanand, Violeta Duran-Laforet, Wassim Elyaman, Elizabeth E Evans, Patricia Fitzgerald-Bocarsly, Kate E Foley, Ashley S Harms, Michael T Heneka, Soyon Hong, Yu-Wen A Huang, Stephanie Jackvony, Laijun Lai, Yann Le Guen, Cynthia A Lemere, Shane A Liddelow, Alfonso Martin-Peña, Anna G Orr, Francisco J Quintana, Grace D Ramey, Jessica E Rexach, Stacey J S Rizzo, Claire Sexton, Alice S Tang, Jose G Torrellas, Andy P Tsai, Lynn van Olst, Keenan A Walker, Whitney Wharton, Malú Gámez Tansey, Donna M Wilcock
Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference