Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias

Authors
Ramiro Eduardo Rea Reyes, Rachael E Wilson, Rebecca E Langhough, Rachel L Studer, Erin M Jonaitis, Julie E Oomens, Elizabeth M Planalp, Barbara B Bendlin, Nathaniel A Chin, Sanjay Asthana, Henrik Zetterberg, Sterling C Johnson
Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias
Cell reports
Published

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease

Authors
Elena Eubanks, Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin Sacks, Mahsa Darestani Farahani, Jinying Wang, Jordan Elliott, Nora Jaber, Fulya Akçimen, Sara Bandres-Ciga, Fadel Helweh, Jun Liu, Sanjana Archakam, Robert Kimelman, Bineet Sharma, Philip Socha, Ananya Guntur, Yiming Huang, Nagendran Ramalingam, Elyse Guadagno, Tim Bartels, Ulf Dettmer, M Maral Mouradian, Amir Houshang Bahrami, Wei Dai, Jean Baum, Zheng Shi, John Hardy, Eleanna Kara
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease
Neurobiology of aging
Published

Presenilin 1 hemizygosity has no overt deleterious phenotypic outcomes in sheep: Potential implications for therapeutic targets in Alzheimer's disease

Authors
Natasha E Mckean, Jun Liu, Skye R Rudiger, Jennifer M Kelly, Clive McLaughlan, Paul J Verma, John Hardy, James F Gusella, Henrik Zetterberg, Suzanne J Reid, Renee H Handley, Klaus Lehnert, Greg T Sutherland, Amanda Heslegrave, Elena Veleva, Rhiannon Laban, John F Pearson, Simon C Bawden, Russell G Snell
Presenilin 1 hemizygosity has no overt deleterious phenotypic outcomes in sheep: Potential implications for therapeutic targets in Alzheimer's disease
Nature communications
Published

Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures

Authors
Robert I McGeachan, Soraya Meftah, Lewis W Taylor, James H Catterson, Danilo Negro, Calum Bonthron, Kristján Holt, Jane Tulloch, Jamie L Rose, Francesco Gobbo, Ya Yin Chang, Jamie Elliott, Lauren McLay, Declan King, Imran Liaquat, Tara L Spires-Jones, Sam A Booker, Paul M Brennan, Claire S Durrant
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
European journal of endocrinology
Published

Sex differences between mid-life glycaemic traits and brain volume at age 70: A population-based study

Authors
Nasri Fatih, Alun Hughes, Carole H Sudre, Nish Chaturvedi, Victoria Garfield, Richard J Silverwood, George Ploubidis, Thomas D Parker, Kirsty Lu, David M Cash, Ian B Malone, Andrew Wong, Josephine Barnes, Marcus Richards, Nick C Fox, Jonathan M Schott, Sarah-Naomi James
Sex differences between mid-life glycaemic traits and brain volume at age 70: A population-based study
Scientific reports
Published

Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions

Authors
Huseyin Kilili, Benjamin Padilla-Morales, Atahualpa Castillo-Morales, Jimena Monzón-Sandoval, Karina Díaz-Barba, Paola Cornejo-Paramo, Orsolya Vincze, Mathieu Giraudeau, Stephen J Bush, Zhidan Li, Lu Chen, Evangelos Mourkas, Sergio Ancona, Alejandro Gonzalez-Voyer, Diego Cortez, Humberto Gutierrez, Tamás Székely, Alín P Acuña-Alonzo, Araxi O Urrutia
Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions
Cell
Published

Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

Authors
Samuel S Harris, Robert Ellingford, Jana Hartmann, Debanjan Dasgupta, Marten Kehring, Rikesh M Rajani, David Graykowski, Noé Quittot, Dhanush Sivasankaran, Caitlin Commins, Zhanyun Fan, Suraya A Bond, Fred Wolf, David Dupret, Raymond J Dolan, Arthur Konnerth, Andreas Neef, Bradley T Hyman, Marc Aurel Busche
Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Resilience in Alzheimer's disease: Impact of operationalization and methodological choices

Authors
Sophie Mutel, Lara Quatrocchi, Daniele Altomare, Christian Chicherio, Max Scheffler, Karl-Olof Lövblad, Kaj Blennow, Nicholas J Ashton, Henrik Zetterberg, Marc Abramowicz, Jean-Louis Blouin, Chen Wang, Carine Wyss-Dominguez, Augusto J Mendes, Valentina Garibotto, Giovanni Frisoni, Federica Ribaldi
Resilience in Alzheimer's disease: Impact of operationalization and methodological choices
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

A comparison of p-tau assays for the specificity to detect tau changes in Alzheimer's disease

Authors
Shorena Janelidze, Nicholas J Ashton, Anna Orduña Dolado, Ulrika Nordström, Divya Bali, Karin M E Forsberg, Isil Keskin, Andrea Mastrangelo, Veria Vacchiano, Rocco Liguori, Kaj Blennow, Henrik Zetterberg, Niklas Mattsson-Carlgren, Fernando Gonzalez-Ortiz, Piero Parchi, Peter Munch Andersen, Oskar Hansson
A comparison of p-tau assays for the specificity to detect tau changes in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Exploring inflammation-related protein expression and its relationship with TSPO PET in Alzheimer's disease

Authors
Ilaria Pola, Nicholas J Ashton, Marco Antônio De Bastiani, Wagner S Brum, Nesrine Rahmouni, Kubra Tan, Luiza Santos Machado, Stijn Servaes, Jenna Stevenson, Cécile Tissot, Joseph Therriault, Tharick A Pascoal, Kaj Blennow, Henrik Zetterberg, Eduardo R Zimmer, Pedro Rosa-Neto, Andréa L Benedet
Exploring inflammation-related protein expression and its relationship with TSPO PET in Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study

Authors
Daniela Jaime Garcia, Una Clancy, Carmen Arteaga, Maria C Valdés-Hernandez, Francesca M Chappell, Angela C C Jochems, Yajun Cheng, Junfang Zhang, Michael J Thrippleton, Michael S Stringer, Emilie Sleight, Ellen V Backhouse, Stewart Wiseman, Rosalind Brown, Fergus N Doubal, Axel Montagne, Joanna M Wardlaw, MSS3 Study Group
Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study