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Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Brain : a journal of neurology
Published

Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum

Authors
Jaime Fernández Arias, Wagner S Brum, Gemma Salvadó, Joseph Therriault, Stijn Servaes, Yi-Ting Wang, Etienne Aumont, Nesrine Rahmouni, Arthur Macedo, Kely Quispialaya, Seyyed Ali Hosseini, Peter Kunach, Wan Lu Jia, Tevy Chan, Lydia Trudel, Brandon Hall, Yanseng Zheng, Sejal Mohapatra, Sulantha S Mathotaarachchi, Paolo Vitali, Cécile Tissot, Gleb Bezgin, Yasser Iturria-Medina, Nicholas J Ashton, Andréa Lessa Benedet, Thomas K Karikari, Gallen Triana-Baltzer, Jesse Klostranec, Hartmuth C Kolb, Eduardo R Zimmer, Shorena Janelidze, Niklas Mattson-Carlgren, Erik Stomrud, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Tharick Pascoal, Maxime Montembeault, Oskar Hansson, Pedro Rosa-Neto
Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer's disease spectrum
Journal of neuroinflammation
Published

Characteristics of TSPO expression in marmoset EAE

Authors
Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J Luciano, Joseph Guy, Seung-Kwon Ha, David R Owen, Franklin Aigbirhio, Paul M Matthews, Daniel S Reich, Steven Jacobson
Characteristics of TSPO expression in marmoset EAE
European psychiatry : the journal of the Association of European Psychiatrists
Published

Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts

Authors
A J Edmondson-Stait, E Davyson, X Shen, M J Adams, G M Khandaker, V E Miron, A M McIntosh, S M Lawrie, A S F Kwong, H C Whalley
Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts
Nature communications
Published

Splicing accuracy varies across human introns, tissues, age and disease

Authors
S García-Ruiz, D Zhang, E K Gustavsson, G Rocamora-Perez, M Grant-Peters, A Fairbrother-Browne, R H Reynolds, J W Brenton, A L Gil-Martínez, Z Chen, D C Rio, J A Botia, S Guelfi, L Collado-Torres, M Ryten
Splicing accuracy varies across human introns, tissues, age and disease
bioRxiv : the preprint server for biology
Published

Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk

Authors
Nagham Khouri-Farah, Emma Wentworth Winchester, Brian M Schilder, Kelsey Robinson, Sarah W Curtis, Nathan G Skene, Elizabeth J Leslie-Clarkson, Justin Cotney
Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk
Medicina (Kaunas, Lithuania)
Published

Functional and Cognitive Impairment in Patients with Relapsing-Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels

Authors
Elina Polunosika, Joel Simren, Arta Akmene, Nikita Klimovskis, Kaj Blennow, Daina Pastare, Henrik Zetterberg, Renars Erts, Guntis Karelis
Functional and Cognitive Impairment in Patients with Relapsing-Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels
Clinical epigenetics
Published

Blood-based epigenome-wide association study and prediction of alcohol consumption

Authors
Elena Bernabeu, Aleksandra D Chybowska, Jacob K Kresovich, Matthew Suderman, Daniel L McCartney, Robert F Hillary, Janie Corley, Maria Del C Valdés-Hernández, Susana Muñoz Maniega, Mark E Bastin, Joanna M Wardlaw, Zongli Xu, Dale P Sandler, Archie Campbell, Sarah E Harris, Andrew M McIntosh, Jack A Taylor, Paul Yousefi, Simon R Cox, Kathryn L Evans, Matthew R Robinson, Catalina A Vallejos, Riccardo E Marioni
Blood-based epigenome-wide association study and prediction of alcohol consumption
Cell chemical biology
Published

SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy

Authors
Shekhar Kedia, Emre Fertan, Yunzhao Wu, Yu P Zhang, Georg Meisl, Jeff Y L Lam, Frances K Wiseman, William A McEwan, Annelies Quaegebeur, Maria Grazia Spillantini, John S H Danial, David Klenerman
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Polygenic risk discriminates Lewy body dementia from Alzheimer's disease

Authors
Anna McKeever, Peter Swann, Maura Malpetti, Paul C Donaghy, Alan Thomas, Elijah Mak, Stephen F Carter, Jerry H K Tan, Young T Hong, Tim D Fryer, Amanda Heslegrave, Henrik Zetterberg, Li Su, Leonidas Chouliaras, James B Rowe, John T O'Brien
Polygenic risk discriminates Lewy body dementia from Alzheimer's disease
Brain communications
Published

Identify biological Alzheimer's disease using a novel nucleic acid-linked protein immunoassay

Authors
Yi-Ting Wang, Nicholas J Ashton, Joseph Therriault, Andréa L Benedet, Arthur C Macedo, Ilaria Pola, Etienne Aumont, Guglielmo Di Molfetta, Jaime Fernandez-Arias, Kubra Tan, Nesrine Rahmouni, Stijn Johannes G Servaes, Richard Isaacson, Tevy Chan, Seyyed Ali Hosseini, Cécile Tissot, Sulantha Mathotaarachchi, Jenna Stevenson, Firoza Z Lussier, Tharick A Pascoal, Serge Gauthier, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto
Identify biological Alzheimer's disease using a novel nucleic acid-linked protein immunoassay
Scientific reports
Published

Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms

Authors
Marc Dörner, Malte Pfister, Anthony Tyndall, Roland von Känel, Katja Neumann, Frank Schreiber, Philipp Arndt, Erelle Fuchs, Cornelia Garz, Wenzel Glanz, Michaela Butryn, Anna-Charlotte John, Annkatrin Hildebrand, Sebastian Euler, Andreas B Hofmann, Lena Machetanz, Johannes Kirchebner, Pawel Tacik, Alexander Grimm, Robin Jansen, Marc Pawlitzki, Solveig Henneicke, Valentina Perosa, Bendix Labeit, Emrah Düzel, Sven G Meuth, Stefan Vielhaber, Hendrik Mattern, Jose Bernal, Stefanie Schreiber
Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms