Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

Cytokines released by T cells after encountering cancer cells

A balancing act: preventing an overactive immune system

Research into an immune kill switch holds potential for controlling infections or preventing autoimmunity. The study, led by Prof Jernej Ule (UK DRI at King's)...

Learn more A balancing act: preventing an overactive immune system
Nature metabolism
Published

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases

Authors
Femke M Feringa, Sascha J Koppes-den Hertog, Lian Y Wang, Rico J E Derks, Iris Kruijff, Lena Erlebach, Jorin Heijneman, Ricardo Miramontes, Nadine Pömpner, Niek Blomberg, Damien Olivier-Jimenez, Lill Eva Johansen, Alexander J Cammack, Ashling Giblin, Christina E Toomey, Indigo V L Rose, Hebao Yuan, Michael E Ward, Adrian M Isaacs, Martin Kampmann, Deborah Kronenberg-Versteeg, Tammaryn Lashley, Leslie M Thompson, Alessandro Ori, Yassene Mohammed, Martin Giera, Rik van der Kant
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
Disease models & mechanisms
Published

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

Authors
Roza H A Masalmeh, John C Dawson, Virginia Alvarez Garcia, Morwenna T Muir, Roderick N Carter, Giles Hardingham, Cameron Davies, Rosina Graham, Alex von Kriegsheim, Jair Marques, Chinmayi Pednekar, Steven M Pollard, Neil O Carragher, Valerie G Brunton, Margaret C Frame
FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation
Molecular oncology
Published

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Authors
Adrien M Vaquié, Davod R Shah, Eliane E S Brechbühl, Michael McNicholas, Zhaoyang Xu, John H Stockley, Laura Morcom, Diana Gold Diaz, Gemma C Girdler, Rachel V Seear, Gabriel Balmus, Rajiv R Ratan, Harry Bulstrode, James A Nathan, Manav Pathania, Kevin M Brindle, David H Rowitch
Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
The Lancet. Neurology
Published

Association between the Edinburgh CT and genetic diagnostic criteria for cerebral amyloid angiopathy-associated lobar intracerebral haemorrhage and recurrent intracerebral haemorrhage: an individual patient data meta-analysis

Authors
Mark A Rodrigues, David Seiffge, Neshika Samarasekera, Tom J Moullaali, Joanna M Wardlaw, Stefanie Schreiber, Tyler P Behymer, Vivek Khandwala, Robert J Stanton, Vaibhav Vagal, Daniel Woo, Marialuisa Zedde, Rosario Pascarella, Andreas Charidimou, Andrew Warren, Steven M Greenberg, Sebastian Eppinger, Thomas Gattringer, Barbara Casolla, Charlotte Cordonnier, David J Werring, Rustam Al-Shahi Salman, Edinburgh CAA criteria prognosis collaborators
Association between the Edinburgh CT and genetic diagnostic criteria for cerebral amyloid angiopathy-associated lobar intracerebral haemorrhage and recurrent intracerebral haemorrhage: an individual patient data meta-analysis
European stroke journal
Published

Randomised, controlled Trial of CT perfusion and angiography compared to CT alone in thrombolysis-eligible acute ischaemic stroke patients: The penumbra and recanalisation acute computed tomography in ischaemic stroke evaluation (PRACTISE) trial

Authors
Keith W Muir, Salwa El Tawil, Alex McConnachie, Ian Ford, Grant Mair, Jattinder Khaira, Kausik Chatterjee, Laszlo Sztriha, Omid Halse, Ibrahim Balogun, Sanjeev Nayak, Phil White, Elizabeth A Warburton, Joanna Wardlaw
Randomised, controlled Trial of CT perfusion and angiography compared to CT alone in thrombolysis-eligible acute ischaemic stroke patients: The penumbra and recanalisation acute computed tomography in ischaemic stroke evaluation (PRACTISE) trial
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Mild kidney dysfunction affects the predictive accuracy of blood-based biomarkers for neuropsychological and neuroimaging outcomes over a 9 year follow-up period

Authors
Corey J Bolton, Panpan Zhang, Devika Nair, Dandan Liu, L Taylor Davis, Kimberly R Pechman, Niranjana Shashikumar, Sydney Wilhoite, Dominic Roby, Carlie Beeson, Haley Komorowski, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
Mild kidney dysfunction affects the predictive accuracy of blood-based biomarkers for neuropsychological and neuroimaging outcomes over a 9 year follow-up period
medRxiv : the preprint server for health sciences
Published

Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity

Authors
James W Groves, Veronica Augustina Bot, Daisy Yi Ding, Jennifer Nicholas, Amelia Farinas, Hamilton See-Oh, Sarah-Naomi James, Andrew Wong, Dylan M Williams, Josh King-Robson, Nishi Chaturvedi, Marcus Richards, Tony Wyss-Coray, Jonathan M Schott
Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity
Brain : a journal of neurology
Published

Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer's disease

Authors
Julia Pescoller, Anna Dewenter, Amir Dehsarvi, Anna Steward, Lukas Frontzkowski, Zeyu Zhu, Sebastian N Roemer-Cassiano, Carla Palleis, Fabian Hirsch, Fabian Wagner, Hannah de Bruin, Boris Rauchmann, Robert Perneczky, Johannes Gnörich, Maura Malpetti, Rik Ossenkoppele, Michael Schöll, Johannes Levin, Günter Höglinger, Matthias Brendel, Nicolai Franzmeier
Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer's disease
Clinical chemistry and laboratory medicine
Published

Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays

Authors
Udit Sheth, Rebecca Harrison, Kyle Ferber, Erin G Rosenbaugh, Amanda Bevis, Rohini Khillan, Michael Benatar, Nicole L Bjorklund, Elena Di Daniel, Glenn A Harris, Olga I Kahn, Yongge Liu, Henrik Zetterberg, Laura L Mitic, Danielle Graham, Tania F Gendron
Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassays
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease

Authors
Mieke Nuytten, Marieke Voets, Eveline Debroux, Katrien Princen, Lentel Pringels, Marc Fivaz, Eline Byl, Steven Ramael, Koen De Witte, Mercé Boada, Xavier Morató, Juan Pablo Tartari, Asunción Lafuente, Emilio Franco Macias, Jordi A Matias-Guiu, Everard Vijverberg, Charlotte E Teunissen, Peter Anderer, Vincent Staggs, Vincent Hayman, Anne Corbett, Clive Ballard, John E Harrison, Manfred Windisch, Ann Brinkmalm Westman, Henrik Zetterberg, Sam Dickson, Craig Mallinckrodt, Suzanne Hendrix, Jeffrey Cummings, Gerard Griffioen
Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease
Alzheimer's & dementia (Amsterdam, Netherlands)
Published

Preclinical dementia rating scores are associated with plasma phosphorylated tau-217

Authors
Qi Huang, Erin M Jonaitis, Rachel L Studer, Rachael Wilson, Ramiro Eduardo Rea Reyes, Henrik Zetterberg, Lianlian Du, Bruce P Hermann, Sterling C Johnson, Rebecca E Langhough
Preclinical dementia rating scores are associated with plasma phosphorylated tau-217
Alzheimer's & dementia : the journal of the Alzheimer's Association
Published

Recent advances in neuroimaging of Alzheimer's disease and related dementias

Authors
Julie Ottoy, Nicole Owsicki, Murat Bilgel, Alexa Pichet Binette, Gemma Salvadó, Min Su Kang, David M Cash, Michael Ewers, Renaud La Joie, Laura E M Wisse, Maged Goubran, Tobey Betthauser
Recent advances in neuroimaging of Alzheimer's disease and related dementias