Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

- Research

Genetic changes in brain cells link ageing and Alzheimer’s

Genetic differences that contribute to how long a person will live and their risk of Alzheimer’s disease have been identified in a new study led...

Learn more Genetic changes in brain cells link ageing and Alzheimer’s
Nature
Published

PLD3 gene and processing of APP.

Authors
Pietro Fazzari, Katrien Horre, Amaia M Arranz, Carlo Sala Frigerio, Takashi Saito, Takaomi C Saido, Bart De Strooper
PLD3 gene and processing of APP.
Blood
Published

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

Authors
David Kavanagh, Sarah McGlasson, Alexa Jury, Jac Williams, Neil Scolding, Chris Bellamy, Claudia Gunther, Diane Ritchie, Daniel P Gale, Yashpal S Kanwar, Rachel Challis, Holly Buist, James Overell, Belinda Weller, Oliver Flossmann, Mark Blunden, Eric P Meyer, Thomas Krucker, Stephen J W Evans, Iain L Campbell, Andrew P Jackson, Siddharthan Chandran, David P J Hunt
Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.
Lancet Neurol
Published

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Authors
Natalie S Ryan, Jennifer M Nicholas, Philip S J Weston, Yuying Liang, Tammaryn Lashley, Rita Guerreiro, Gary Adamson, Janna Kenny, Jon Beck, Lucia Chavez-Gutierrez, Bart de Strooper, Tamas Revesz, Janice Holton, Simon Mead, Martin N Rossor, Nick C Fox
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.
Genes Dev
Published

Synthetic lethality between PAXX and XLF in mammalian development.

Authors
Gabriel Balmus, Ana C Barros, Paul W G Wijnhoven, Chloé Lescale, Hélène Lenden Hasse, Katharina Boroviak, Carlos le Sage, Brendan Doe, Anneliese O Speak, Antonella Galli, Matt Jacobsen, Ludovic Deriano, David J Adams, Andrew N Blackford, Stephen P Jackson
Synthetic lethality between PAXX and XLF in mammalian development.
Nat Neurosci
Published

Neuronal activity enhances tau propagation and tau pathology in vivo.

Authors
Jessica W Wu, S Abid Hussaini, Isle M Bastille, Gustavo A Rodriguez, Ana Mrejeru, Kelly Rilett, David W Sanders, Casey Cook, Hongjun Fu, Rick A C M Boonen, Mathieu Herman, Eden Nahmani, Sheina Emrani, Y Helen Figueroa, Marc I Diamond, Catherine L Clelland, Selina Wray, Karen E Duff
Neuronal activity enhances tau propagation and tau pathology in vivo.
Lancet
Published

Alzheimer's disease.

Authors
Philip Scheltens, Kaj Blennow, Monique M B Breteler, Bart de Strooper, Giovanni B Frisoni, Stephen Salloway, Wiesje Maria Van der Flier
Alzheimer's disease.
Science
Published

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Authors
Soyon Hong, Victoria F Beja-Glasser, Bianca M Nfonoyim, Arnaud Frouin, Shaomin Li, Saranya Ramakrishnan, Katherine M Merry, Qiaoqiao Shi, Arnon Rosenthal, Ben A Barres, Cynthia A Lemere, Dennis J Selkoe, Beth Stevens
Complement and microglia mediate early synapse loss in Alzheimer mouse models.