Publications

Our scientific output and findings

From groundbreaking discoveries in basic science to innovative clinical insights, our publications showcase the breadth and depth of research taking place at the UK DRI. 

Featured

man sitting on bed at night
- Research

Sleep problems could double risk of dementia in later life

People who experience sleep disorders are at greater risk of developing dementia and other neurodegenerative conditions later in life, new research led by Prof Valentina...

Learn more Sleep problems could double risk of dementia in later life
Nat Neurosci
Published

Identification of early neurodegenerative pathways in progressive multiple sclerosis.

Authors
Max Kaufmann, Anna-Lena Schaupp, Rosa Sun, Fabian Coscia, Calliope A Dendrou, Adrian Cortes, Gurman Kaur, Hayley G Evans, Annelie Mollbrink, José Fernández Navarro, Jana K Sonner, Christina Mayer, Gabriele C DeLuca, Joakim Lundeberg, Paul M Matthews, Kathrine E Attfield, Manuel A Friese, Matthias Mann, Lars Fugger
Identification of early neurodegenerative pathways in progressive multiple sclerosis.
Neurology
Published

Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort.

Authors
Sarah E Keuss, William Coath, Jennifer M Nicholas, Teresa Poole, Josephine Barnes, David M Cash, Christopher A Lane, Thomas D Parker, Ashvini Keshavan, Sarah M Buchanan, Aaron Z Wagen, Mathew Storey, Matthew Harris, Ian B Malone, Carole H Sudre, Kirsty Lu, Sarah-Naomi James, Rebecca Street, David L Thomas, John C Dickson, Heidi Murray-Smith, Andrew Wong, Tamar Freiberger, Sebastian Crutch, Marcus Richards, Nick C Fox, Jonathan M Schott
Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort.
Science
Published

A specific circuit in the midbrain detects stress and induces restorative sleep.

Authors
Xiao Yu, Guangchao Zhao, Dan Wang, Sa Wang, Rui Li, Ao Li, Huan Wang, Mathieu Nollet, You Young Chun, Tianyuan Zhao, Raquel Yustos, Huiming Li, Jianshuai Zhao, Jiannan Li, Min Cai, Alexei L Vyssotski, Yulong Li, Hailong Dong, Nicholas P Franks, William Wisden
A specific circuit in the midbrain detects stress and induces restorative sleep.
Front Comput Neurosci
Published

Recent Trends in Non-invasive Neural Recording Based Brain-to-Brain Synchrony Analysis on Multidisciplinary Human Interactions for Understanding Brain Dynamics: A Systematic Review.

Authors
Tahnia Nazneen, Iffath Binta Islam, Md Sakibur Rahman Sajal, Wasifa Jamal, M Ashraful Amin, Ravi Vaidyanathan, Tom Chau, Khondaker A Mamun
Recent Trends in Non-invasive Neural Recording Based Brain-to-Brain Synchrony Analysis on Multidisciplinary Human Interactions for Understanding Brain Dynamics: A Systematic Review.
Cell Stem Cell
Published

Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.

Authors
Lucia S Capano, Chihiro Sato, Elena Ficulle, Anan Yu, Kanta Horie, Ji-Sun Kwon, Kyle F Burbach, Nicolas R Barthélemy, Susan G Fox, Celeste M Karch, Randall J Bateman, Henry Houlden, Richard I Morimoto, David M Holtzman, Karen E Duff, Andrew S Yoo
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Acta Neuropathol
Published

Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.

Authors
Sophie Quick, Tessa V Procter, Jonathan Moss, Luise Seeker, Marc Walton, Angus Lawson, Serena Baker, Anna Beletski, Daniela Jaime Garcia, Mehreen Mohammad, William Mungall, Ami Onishi, Zuzanna Tobola, Michael Stringer, Maurits A Jansen, Antoine Vallatos, Ylenia Giarratano, Miguel O Bernabeu, Joanna M Wardlaw, Anna Williams
Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model.
Cell Rep
Published

Cholesterol determines the cytosolic entry and seeded aggregation of tau.

Authors
Benjamin J Tuck, Lauren V C Miller, Taxiarchis Katsinelos, Annabel E Smith, Emma L Wilson, Sophie Keeling, Shi Cheng, Marina J Vaysburd, Claire Knox, Lucy Tredgett, Emmanouil Metzakopian, Leo C James, William A McEwan
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Exp Neurol
Published

DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.

Authors
Mayela Zamora, Robert Toth, Francesca Morgante, Jon Ottaway, Tom Gillbe, Sean Martin, Guy Lamb, Tara Noone, Moaad Benjaber, Zachary Nairac, Devang Sehgal, Timothy G Constandinou, Jeffrey Herron, Tipu Z Aziz, Ivor Gillbe, Alexander L Green, Erlick A C Pereira, Timothy Denison
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.